Incidence and risk factors for central venous access port-related infection in Chinese cancer patients

Ting Yao Wang, Kuan Der Lee, Ping Tsung Chen, Min Chi Chen, Yi Yang Chen, Cih En Huang, Feng Che Kuan, Chih Cheng Chen, Chang Hsien Lu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background/Purpose: Cytotoxic chemotherapy via central venous access ports is an important part of the standard treatment for most cancers, but it is accompanied with the risk of infections. This study aimed to analyze the incidence and risk factors for central venous access port-related infection (CPI) among Chinese patients receiving cytotoxic chemotherapy. Methods: Between January 1, 2002 and December 31, 2005 a total of 1391 cancer patients with 1449 totally implantable central venous access ports were evaluated. The log-rank test and Cox proportional hazards model were used for the analyses of risk factors. Results: The overall CPI incidence rate was 0.21 per 1000 catheter-days. Hematological malignancies and head and neck cancer were associated with an increased risk of CPI (hazard ratio 4.00 and 4.11, respectively, both p < 0.001) and less infection-free catheter longevity (p < 0.001) compared with other cancer types. Chemotherapy in an adjuvant setting was associated with a lower risk of infection than for patients in a nonadjuvant setting (p < 0.001). The most common pathogens isolated from CPI were Pseudomonas aeruginosa and Candida. Conclusion: Infection remains to be a challenging issue for totally implantable central venous ports. Implementation of an insertion bundle for the prevention of central line-associated bloodstream infections is warranted, especially for those patients with hematological and head and neck cancers, as well as for patients receiving chemotherapy in the metastatic settings.

Original languageEnglish
Pages (from-to)1055-1060
Number of pages6
JournalJournal of the Formosan Medical Association
Volume114
Issue number11
DOIs
Publication statusPublished - Nov 1 2015
Externally publishedYes

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Incidence
Infection
Neoplasms
Head and Neck Neoplasms
Drug Therapy
Catheters
Hematologic Neoplasms
Adjuvant Chemotherapy
Candida
Proportional Hazards Models
Pseudomonas aeruginosa
cyclopropapyrroloindole
Therapeutics

Keywords

  • Cancer care facilities
  • Catheter-related infections
  • Vascular access devices

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Incidence and risk factors for central venous access port-related infection in Chinese cancer patients. / Wang, Ting Yao; Lee, Kuan Der; Chen, Ping Tsung; Chen, Min Chi; Chen, Yi Yang; Huang, Cih En; Kuan, Feng Che; Chen, Chih Cheng; Lu, Chang Hsien.

In: Journal of the Formosan Medical Association, Vol. 114, No. 11, 01.11.2015, p. 1055-1060.

Research output: Contribution to journalArticle

Wang, Ting Yao ; Lee, Kuan Der ; Chen, Ping Tsung ; Chen, Min Chi ; Chen, Yi Yang ; Huang, Cih En ; Kuan, Feng Che ; Chen, Chih Cheng ; Lu, Chang Hsien. / Incidence and risk factors for central venous access port-related infection in Chinese cancer patients. In: Journal of the Formosan Medical Association. 2015 ; Vol. 114, No. 11. pp. 1055-1060.
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