Incidence and factors associated with recurrence patterns after intended curative surgery for gastric cancer

Chew Wun Wu, Su Shun Lo, King Han Shen, Mao-Chih Hsieh, Jen Hao Chen, Jen Huey Chiang, Hwai Jeng Lin, Anna F Y Li, Wing Yiu Lui

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Abstract

Recurrence after curative resection for gastric cancer remains high. We examined its incidence and factors related to recurrence pattern, while trying to avoid the interaction of various factors. A total of 611 gastric cancer patients after resection for curative intent (1988-1995) were analyzed. The result showed that 245 patients had recurrence (40.1%). Cumulative recurrence rates were 53.5%, 80%, 89.0%, 94.7%, 96.3%, 98%, and 99.5% at 1, 2, 3, 4, 5, 6, and 7 years, respectively. Over half of patients with recurrence (123; 50.2%) had an initial single recurrence. Taking single and multiple recurrence together, most recurrences (213; 86.9%) were distant metastases, 110 recurrences (44.9%) were local relapses, and 78 recurrences (49.8%) were both local and distant. Among the distant metastases, 131 patients (53.5%) had peritoneal dissemination, 106 patients (43.3%) had hematogenous metastases, and 70 patients (28.6%) had distant lymphatic spread. Scirrhous-type stromal reaction, serosa invasion, and female gender were factors negatively related to peritoneal recurrence. Medullary-type stromal reaction and male gender showed a preference for locoregional recurrence, and expanding growth tumor commonly led to hematogenous metastasis. Patients who had paraaortic lymph node metastasis were at high risk of developing distant lymphatic recurrence. It is conceivable that the patterns of recurrence and the times to recurrence provide a biological basis for clinical monitoring of patients with the aim of modifying therapeutic modalities.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalWorld Journal of Surgery
Volume27
Issue number2
Publication statusPublished - Feb 2003

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Stomach Neoplasms
Recurrence
Incidence
Neoplasm Metastasis
Serous Membrane
Physiologic Monitoring
Lymph Nodes

ASJC Scopus subject areas

  • Surgery

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Wu, C. W., Lo, S. S., Shen, K. H., Hsieh, M-C., Chen, J. H., Chiang, J. H., ... Lui, W. Y. (2003). Incidence and factors associated with recurrence patterns after intended curative surgery for gastric cancer. World Journal of Surgery, 27(2), 153-158.

Incidence and factors associated with recurrence patterns after intended curative surgery for gastric cancer. / Wu, Chew Wun; Lo, Su Shun; Shen, King Han; Hsieh, Mao-Chih; Chen, Jen Hao; Chiang, Jen Huey; Lin, Hwai Jeng; Li, Anna F Y; Lui, Wing Yiu.

In: World Journal of Surgery, Vol. 27, No. 2, 02.2003, p. 153-158.

Research output: Contribution to journalArticle

Wu, CW, Lo, SS, Shen, KH, Hsieh, M-C, Chen, JH, Chiang, JH, Lin, HJ, Li, AFY & Lui, WY 2003, 'Incidence and factors associated with recurrence patterns after intended curative surgery for gastric cancer', World Journal of Surgery, vol. 27, no. 2, pp. 153-158.
Wu, Chew Wun ; Lo, Su Shun ; Shen, King Han ; Hsieh, Mao-Chih ; Chen, Jen Hao ; Chiang, Jen Huey ; Lin, Hwai Jeng ; Li, Anna F Y ; Lui, Wing Yiu. / Incidence and factors associated with recurrence patterns after intended curative surgery for gastric cancer. In: World Journal of Surgery. 2003 ; Vol. 27, No. 2. pp. 153-158.
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abstract = "Recurrence after curative resection for gastric cancer remains high. We examined its incidence and factors related to recurrence pattern, while trying to avoid the interaction of various factors. A total of 611 gastric cancer patients after resection for curative intent (1988-1995) were analyzed. The result showed that 245 patients had recurrence (40.1{\%}). Cumulative recurrence rates were 53.5{\%}, 80{\%}, 89.0{\%}, 94.7{\%}, 96.3{\%}, 98{\%}, and 99.5{\%} at 1, 2, 3, 4, 5, 6, and 7 years, respectively. Over half of patients with recurrence (123; 50.2{\%}) had an initial single recurrence. Taking single and multiple recurrence together, most recurrences (213; 86.9{\%}) were distant metastases, 110 recurrences (44.9{\%}) were local relapses, and 78 recurrences (49.8{\%}) were both local and distant. Among the distant metastases, 131 patients (53.5{\%}) had peritoneal dissemination, 106 patients (43.3{\%}) had hematogenous metastases, and 70 patients (28.6{\%}) had distant lymphatic spread. Scirrhous-type stromal reaction, serosa invasion, and female gender were factors negatively related to peritoneal recurrence. Medullary-type stromal reaction and male gender showed a preference for locoregional recurrence, and expanding growth tumor commonly led to hematogenous metastasis. Patients who had paraaortic lymph node metastasis were at high risk of developing distant lymphatic recurrence. It is conceivable that the patterns of recurrence and the times to recurrence provide a biological basis for clinical monitoring of patients with the aim of modifying therapeutic modalities.",
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