In vivo production and enzyme-inducing activity of indolo[3,2-6]carbazole

Chong Suk Kwon, Karl R. Grose, Jacques Riby, Yue Hwa Chen, Leonard F. Bjeldanes

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Indolo[3,2-6]carbazole (ICZ) is a potent Ah receptor agonist produced during the oligomerization of indole-3-carbinol (I3C), a breakdown product of the glucobrassicin present in food plants of the Brassica genus. Levels of ICZ present in the feces, urine, gastrointestinal tracts, and livers of rats fed on I3C- or cabbage-supplemented basal diet were 16-fold to over 100-fold higher than levels for animals on the basal diet alone. Levels of ICZ significantly lower than the basal levels for conventional rats were present in feces of germfree rats, indicating that gut bacteria are important for the production of ICZ from essential dietary constituents. Low levels of ICZ in extracts of human feces were also detected. The results suggest further that ICZ by itself may not be responsible for the enzyme-inducing activity of orally administered I3C or its precursors.

Original languageEnglish
Pages (from-to)2536-2540
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Volume42
Issue number11
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

carbazoles
Enzyme activity
indoles
Feces
Rats
feces
Brassica
Nutrition
rats
Enzymes
enzymes
glucobrassicin
Diet
Oligomerization
Edible Plants
food plants
cabbage
diet
Liver
agonists

Keywords

  • Brassica
  • Cytochrome P450
  • Endogenous inducer
  • Indole-3-carbinol
  • Indolo[3,2-b]carbazole

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)

Cite this

Kwon, C. S., Grose, K. R., Riby, J., Chen, Y. H., & Bjeldanes, L. F. (1994). In vivo production and enzyme-inducing activity of indolo[3,2-6]carbazole. Journal of Agricultural and Food Chemistry, 42(11), 2536-2540.

In vivo production and enzyme-inducing activity of indolo[3,2-6]carbazole. / Kwon, Chong Suk; Grose, Karl R.; Riby, Jacques; Chen, Yue Hwa; Bjeldanes, Leonard F.

In: Journal of Agricultural and Food Chemistry, Vol. 42, No. 11, 1994, p. 2536-2540.

Research output: Contribution to journalArticle

Kwon, CS, Grose, KR, Riby, J, Chen, YH & Bjeldanes, LF 1994, 'In vivo production and enzyme-inducing activity of indolo[3,2-6]carbazole', Journal of Agricultural and Food Chemistry, vol. 42, no. 11, pp. 2536-2540.
Kwon, Chong Suk ; Grose, Karl R. ; Riby, Jacques ; Chen, Yue Hwa ; Bjeldanes, Leonard F. / In vivo production and enzyme-inducing activity of indolo[3,2-6]carbazole. In: Journal of Agricultural and Food Chemistry. 1994 ; Vol. 42, No. 11. pp. 2536-2540.
@article{3569dd1e1837497fa9343b7c7505c80c,
title = "In vivo production and enzyme-inducing activity of indolo[3,2-6]carbazole",
abstract = "Indolo[3,2-6]carbazole (ICZ) is a potent Ah receptor agonist produced during the oligomerization of indole-3-carbinol (I3C), a breakdown product of the glucobrassicin present in food plants of the Brassica genus. Levels of ICZ present in the feces, urine, gastrointestinal tracts, and livers of rats fed on I3C- or cabbage-supplemented basal diet were 16-fold to over 100-fold higher than levels for animals on the basal diet alone. Levels of ICZ significantly lower than the basal levels for conventional rats were present in feces of germfree rats, indicating that gut bacteria are important for the production of ICZ from essential dietary constituents. Low levels of ICZ in extracts of human feces were also detected. The results suggest further that ICZ by itself may not be responsible for the enzyme-inducing activity of orally administered I3C or its precursors.",
keywords = "Brassica, Cytochrome P450, Endogenous inducer, Indole-3-carbinol, Indolo[3,2-b]carbazole",
author = "Kwon, {Chong Suk} and Grose, {Karl R.} and Jacques Riby and Chen, {Yue Hwa} and Bjeldanes, {Leonard F.}",
year = "1994",
language = "English",
volume = "42",
pages = "2536--2540",
journal = "Journal of Agricultural and Food Chemistry",
issn = "0021-8561",
publisher = "American Chemical Society",
number = "11",

}

TY - JOUR

T1 - In vivo production and enzyme-inducing activity of indolo[3,2-6]carbazole

AU - Kwon, Chong Suk

AU - Grose, Karl R.

AU - Riby, Jacques

AU - Chen, Yue Hwa

AU - Bjeldanes, Leonard F.

PY - 1994

Y1 - 1994

N2 - Indolo[3,2-6]carbazole (ICZ) is a potent Ah receptor agonist produced during the oligomerization of indole-3-carbinol (I3C), a breakdown product of the glucobrassicin present in food plants of the Brassica genus. Levels of ICZ present in the feces, urine, gastrointestinal tracts, and livers of rats fed on I3C- or cabbage-supplemented basal diet were 16-fold to over 100-fold higher than levels for animals on the basal diet alone. Levels of ICZ significantly lower than the basal levels for conventional rats were present in feces of germfree rats, indicating that gut bacteria are important for the production of ICZ from essential dietary constituents. Low levels of ICZ in extracts of human feces were also detected. The results suggest further that ICZ by itself may not be responsible for the enzyme-inducing activity of orally administered I3C or its precursors.

AB - Indolo[3,2-6]carbazole (ICZ) is a potent Ah receptor agonist produced during the oligomerization of indole-3-carbinol (I3C), a breakdown product of the glucobrassicin present in food plants of the Brassica genus. Levels of ICZ present in the feces, urine, gastrointestinal tracts, and livers of rats fed on I3C- or cabbage-supplemented basal diet were 16-fold to over 100-fold higher than levels for animals on the basal diet alone. Levels of ICZ significantly lower than the basal levels for conventional rats were present in feces of germfree rats, indicating that gut bacteria are important for the production of ICZ from essential dietary constituents. Low levels of ICZ in extracts of human feces were also detected. The results suggest further that ICZ by itself may not be responsible for the enzyme-inducing activity of orally administered I3C or its precursors.

KW - Brassica

KW - Cytochrome P450

KW - Endogenous inducer

KW - Indole-3-carbinol

KW - Indolo[3,2-b]carbazole

UR - http://www.scopus.com/inward/record.url?scp=0000457475&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0000457475&partnerID=8YFLogxK

M3 - Article

VL - 42

SP - 2536

EP - 2540

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

IS - 11

ER -