Abstract

Fe3O4 nanoparticles were loaded into poly-L-lactide (PLLA) with concentrations of 2% and 5%, respectively, using an electrospinning method. In vivo animal experiments were then performed to evaluate the potential of the Fe3O4/PLLA nanofibrous material for bone tissue engineering applications. Bony defects with a diameter of 4 mm were prepared in rabbit tibias. Fe3O4/PLLA nanofibers were grafted into the drilled defects and histological examination and computed tomography (CT) image detection were performed after an eight-week healing period. The histological results showed that the artificial bony defects grafted with Fe3O4/PLLA nanofibers exhibited a visibly higher bone healing activity than those grafted with neat PLLA. In addition, the quantitative results from CT images revealed that the bony defects grafted with 2% and 5% Fe3O4/PLLA nanofibers, respectively, showed 1.9-and 2.3-fold increases in bone volume compared to the control blank sample. Overall, the results suggest that the Fe3O4/PLLA nanofibers fabricated in this study may serve as a useful biomaterial for future bone tissue engineering applications.

Original languageEnglish
Article number804
JournalPolymers
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 22 2018

Fingerprint

Nanofibers
Tissue engineering
Bone
Defects
Tomography
Electrospinning
Biomaterials
Animals
Nanoparticles
Biocompatible Materials
poly(lactide)
Experiments

Keywords

  • Electrospinning
  • FeO
  • Osteogensis
  • Poly-L-lactide

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics

Cite this

In vivo investigation into effectiveness of Fe3O4/PLLA nanofibers for bone tissue engineering applications. / Lai, Wei Yi; Feng, Sheng Wei; Chan, Ya Hui; Chang, Wei Jen; Wang, Hsin Ta; Huang, Haw Ming.

In: Polymers, Vol. 10, No. 7, 804, 22.07.2018.

Research output: Contribution to journalArticle

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AU - Huang, Haw Ming

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