Abstract

The ability to promote new bone formation of poor crystalline hydroxyapatite (PC-HA) based biphasic calcium phosphate (BCP) bone substitutes were investigated. Various ratios of porous PC-HA/β-TCP (70/30, 60/40, and 0/100) grafts were fabricated. SEM and XRD measurements were performed to study the morphology and crystalline structure. Cylindrical artificial bone defects (3×6 mm2) were produced in alveolar bone at premolars extraction site and then filled with sterilized bone grafts. Commercial MBCP® and unfilled empty defect served as control groups. At 8 weeks postoperation, samples were harvested from each artificial defect site for histological analysis. New bone formation of all the PC-HA/β-TCP groups was significantly greater than that of the empty control group (p

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalDental Materials Journal
Volume30
Issue number1
DOIs
Publication statusPublished - 2011

Fingerprint

Bone Substitutes
Calcium phosphate
Durapatite
Hydroxyapatite
Grafts
Bone
Crystalline materials
Transplants
Osteogenesis
Bone and Bones
Control Groups
Bicuspid
Defects
hydroxyapatite-beta tricalcium phosphate
Scanning electron microscopy

Keywords

  • β-tricalcium phosphate
  • Biphasic calcium phosphate
  • Bone graft
  • Hydroxyapatite
  • In vivo

ASJC Scopus subject areas

  • Dentistry(all)
  • Ceramics and Composites

Cite this

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title = "In vivo graft performance of an improved bone substitute composed of poor crystalline hydroxyapatite based biphasic calcium phosphate",
abstract = "The ability to promote new bone formation of poor crystalline hydroxyapatite (PC-HA) based biphasic calcium phosphate (BCP) bone substitutes were investigated. Various ratios of porous PC-HA/β-TCP (70/30, 60/40, and 0/100) grafts were fabricated. SEM and XRD measurements were performed to study the morphology and crystalline structure. Cylindrical artificial bone defects (3×6 mm2) were produced in alveolar bone at premolars extraction site and then filled with sterilized bone grafts. Commercial MBCP{\circledR} and unfilled empty defect served as control groups. At 8 weeks postoperation, samples were harvested from each artificial defect site for histological analysis. New bone formation of all the PC-HA/β-TCP groups was significantly greater than that of the empty control group (p",
keywords = "β-tricalcium phosphate, Biphasic calcium phosphate, Bone graft, Hydroxyapatite, In vivo",
author = "Hung, {Ching Lien} and Yang, {Jen Chang} and Chang, {Wei Jen} and Hu, {Chih Yuan} and Lin, {Yong Ho} and Huang, {Chun Hsien} and Chen, {Chien Chung} and Lee, {Sheng Yang} and Teng, {Nai Chia}",
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T1 - In vivo graft performance of an improved bone substitute composed of poor crystalline hydroxyapatite based biphasic calcium phosphate

AU - Hung, Ching Lien

AU - Yang, Jen Chang

AU - Chang, Wei Jen

AU - Hu, Chih Yuan

AU - Lin, Yong Ho

AU - Huang, Chun Hsien

AU - Chen, Chien Chung

AU - Lee, Sheng Yang

AU - Teng, Nai Chia

PY - 2011

Y1 - 2011

N2 - The ability to promote new bone formation of poor crystalline hydroxyapatite (PC-HA) based biphasic calcium phosphate (BCP) bone substitutes were investigated. Various ratios of porous PC-HA/β-TCP (70/30, 60/40, and 0/100) grafts were fabricated. SEM and XRD measurements were performed to study the morphology and crystalline structure. Cylindrical artificial bone defects (3×6 mm2) were produced in alveolar bone at premolars extraction site and then filled with sterilized bone grafts. Commercial MBCP® and unfilled empty defect served as control groups. At 8 weeks postoperation, samples were harvested from each artificial defect site for histological analysis. New bone formation of all the PC-HA/β-TCP groups was significantly greater than that of the empty control group (p

AB - The ability to promote new bone formation of poor crystalline hydroxyapatite (PC-HA) based biphasic calcium phosphate (BCP) bone substitutes were investigated. Various ratios of porous PC-HA/β-TCP (70/30, 60/40, and 0/100) grafts were fabricated. SEM and XRD measurements were performed to study the morphology and crystalline structure. Cylindrical artificial bone defects (3×6 mm2) were produced in alveolar bone at premolars extraction site and then filled with sterilized bone grafts. Commercial MBCP® and unfilled empty defect served as control groups. At 8 weeks postoperation, samples were harvested from each artificial defect site for histological analysis. New bone formation of all the PC-HA/β-TCP groups was significantly greater than that of the empty control group (p

KW - β-tricalcium phosphate

KW - Biphasic calcium phosphate

KW - Bone graft

KW - Hydroxyapatite

KW - In vivo

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