In vivo biological response to highly cross-linked and vitamin e-doped polyethylene - A particle-Induced osteolysis animal study

Chang Hung Huang, Yung Chang Lu, Ting Kuo Chang, I. Lin Hsiao, Yi Ching Su, Shu Ting Yeh, Hsu Wei Fang, Chun Hsiung Huang

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Polyethylene particle-induced osteolysis is the primary limitation in the long-term success of total joint replacement with conventional ultra high molecular weight polyethylene (UHMWPE). Highly cross-linked polyethylene (HXLPE) and vitamin E-doped cross-linked polyethylene (VE-HXLPE) have been developed to increase the wear resistance of joint surfaces. However, very few studies have reported on the incidence of particle-induced osteolysis for these novel materials. The aim of this study was to use a particle-induced osteolysis animal model to compare the in vivo biological response to different polymer particles. Three commercially available polymers (UHMWPE, HXLPE, and VE-HXLPE) were compared. Osseous properties including the bone volume relative to the tissue volume (BV/TV), trabecular thickness (Tb. Th), and bone mineral density (BMD) were examined using micro computed tomography. Histological analysis was used to observe tissue inflammation in each group. This study demonstrated that the osseous properties and noticeable inflammatory reactions were obviously decreased in the HXLPE group. When compared with the sham group, a decrease of 12.7% was found in BV/TV, 9.6% in BMD and 8.3% in Tb.Th for the HXLPE group. The heightened inflammatory response in the HXLPE group could be due to its smaller size and greater amount of implanted particles. Vitamin E diffused in vivo may not affect the inflammatory and osteolytic responses in this model. The morphological size and total cumulative amount of implanted particles could be critical factors in determining the biological response.

Original languageEnglish
Pages (from-to)561-567
Number of pages7
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Issue number3
Publication statusPublished - Apr 1 2016
Externally publishedYes


  • antioxidant
  • cross-linked
  • osteolysis
  • particulate debris
  • polyethylene

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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