In vivo and in vitro anti-tumor effects of fungal extracts

Hung Tsung Wu, Feng Hwa Lu, Yu Chu Su, Horng Yih Ou, Hao Chang Hung, Jin Shang Wu, Yi Ching Yang, Chih Jen Chang

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Fungal extracts are extensively used as nutritional supplements in Far-Eastern Asia. In this study, we aimed to evaluate the anti-cancer activities of some different fungal species against different cancer cell lines. The water or ethanol extracts of Fomitopsis pinicola (F. pinicola), Ganoderma sinense, Fomitopsis officinalis, Polyporus melanopus, and Taiwanofungus camphorates were used to evaluate the anti-cancer activities in various cancer cells. We found that all of the fungi ethanol extracts used in this study exert anti-cancer activities in vitro, whereas water extracts show lower inhibitory activities as determined by 3-(4,5-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Among the tested fungi species, F. pinicola ethanol extract exerts the most significant anti-cancer activity (growth inhibitory ratio 82.8%, p < 0.001) by increasing cell apoptosis. Moreover, F. pinicola ethanol extract significantly decreased tumor size (tumor growth inhibitory ratio 54%, p < 0.05) and increased the lifespan in mice bearing sarcoma-180 tumors. Taken together, this is the first study indicating the anti-tumor effect of F. pinicola in vivo and in vitro. F. pinicola ethanol extract induces cell apoptosis to exert a significant anti-tumor activity, with potential to be a new alternative anti-tumor medicine.

Original languageEnglish
Pages (from-to)2546-2556
Number of pages11
JournalMolecules
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 1 2014
Externally publishedYes

Keywords

  • Apoptosis
  • Cancer
  • F. pinicola
  • Sarcoma-180 cells
  • Tumors

ASJC Scopus subject areas

  • Organic Chemistry

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