In vitro study of drug loading on polymer-free oxide films of metallic implants

Chun Ming Shih, Chun Che Shih, Yea Yang Su, Nen Chung Chang, Shing Jong Lin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Traditionally, a drug that is loaded onto a metallic surface has to use various polymer bondings as its platform. Unfortunately, polymer coatings on a metallic surface cause numerous problems after implantation, such as late thrombosis, inflammation, and restenosis. This research was conducted to investigate whether an oxide layer can be used as a polymer-free platform for drug loading, especially for cardiovascular stents. The interaction and loading of heparin onto different oxide films on 316LVM stainless steel wire was confirmed in vitro by experimental studies using linear voltammetry, electrochemical impedance spectroscopy, and electron spectroscopy for chemical analysis. The eluting of heparin from heparinized surface was studied by using high-performance liquid chromatography, and activated clotting time in addition to linear voltammetry and electron spectroscopy for chemical analysis analyses. Experimental results show that amorphous oxide could be a potential substitute for the polymer coating of drug-loaded stents for minimizing metallic corrosion, inflammation, late thrombosis, and restenosis.

Original languageEnglish
Pages (from-to)519-529
Number of pages11
JournalJournal of Biomedical Materials Research - Part A
Volume75
Issue number3
DOIs
Publication statusPublished - Dec 2005

Fingerprint

Oxide films
Polymers
Stents
Electron spectroscopy
Voltammetry
Pharmaceutical Preparations
Oxides
Heparin
Coatings
Stainless Steel
High performance liquid chromatography
Chemical analysis
Electrochemical impedance spectroscopy
Stainless steel
Wire
Corrosion

Keywords

  • Amorphous oxide
  • Drug-loading
  • Heparin
  • Stainless steel

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

In vitro study of drug loading on polymer-free oxide films of metallic implants. / Shih, Chun Ming; Shih, Chun Che; Su, Yea Yang; Chang, Nen Chung; Lin, Shing Jong.

In: Journal of Biomedical Materials Research - Part A, Vol. 75, No. 3, 12.2005, p. 519-529.

Research output: Contribution to journalArticle

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