In vitro screening of antimotility effect on human sperm with polyphenolic compounds purified from Chinese herbal medicines

H. S. Chiang, S. P. Wang, F. L. Hsu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Twenty-four kinds of pure compounds extracted from Chinese herbal medicines were studied for their effects on the human sperm motility. Seven of them were found to inhibit sperm motility at the concentration of 2 mg/ml. These 7 substances were further investigated for their sperm motility- inhibitory effect at the concentration of 3.0 mg/ml, 4.5 mg/ml, 6.75 mg/ml to test the dose-related response. The results showed that 5 of the 7 extracts, namely casuarinin, cinnamtannin B-1, pedunculagin, epicatchin-(4β-8)- epicatechin-(4β-8)-catechin and catechin have strong inhibitory effect on sperm motility with dose-response relationship. Since the chemical structures of these extracts have already been determined, further studies should aim to explore the mechanisms of their antimotility effect on human sperm. It would appear that some traditional chinese herbal medicine have the potential of becoming new and acceptable forms of male oral contraceptives in the future.

Original languageEnglish
Pages (from-to)239-246
Number of pages8
JournalAdvances in Contraceptive Delivery Systems
Volume8
Issue number3
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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