In Vitro efficacies and resistance profiles of rifampin-based combination regimens for biofilm-embedded methicillin-resistant Staphylococcus aureus

Hung Jen Tang, Chi Chung Chen, Kuo Chen Cheng, Kuan Ying Wu, Yi Chung Lin, Chun Cheng Zhang, Tzu Chieh Weng, Wen Liang Yu, Yu Hsin Chiu, Han Siong Toh, Shyh Ren Chiang, Bo An Su, Wen Chien Ko, Yin Ching Chuang

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37 Citations (Scopus)

Abstract

To compare the in vitro antibacterial efficacies and resistance profiles of rifampin-based combinations against methicillin-resistant Staphylococcus aureus (MRSA) in a biofilm model, the antibacterial activities of vancomycin, teicoplanin, daptomycin, minocycline, linezolid, fusidic acid, fosfomycin, and tigecycline alone or in combination with rifampin against biofilm-embedded MRSA were measured. The rifampin-resistant mutation frequencies were evaluated. Of the rifampin-based combinations, rifampin enhances the antibacterial activities of and even synergizes with fusidic acid, tigecycline, and, to a lesser extent, linezolid, fosfomycin, and minocycline against biofilm-embedded MRSA. Such combinations with weaker rifampin resistance induction activities may provide a therapeutic advantage in MRSA biofilm-related infections.

Original languageEnglish
Pages (from-to)5717-5720
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number11
DOIs
Publication statusPublished - Nov 2013
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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    Tang, H. J., Chen, C. C., Cheng, K. C., Wu, K. Y., Lin, Y. C., Zhang, C. C., Weng, T. C., Yu, W. L., Chiu, Y. H., Toh, H. S., Chiang, S. R., Su, B. A., Ko, W. C., & Chuang, Y. C. (2013). In Vitro efficacies and resistance profiles of rifampin-based combination regimens for biofilm-embedded methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 57(11), 5717-5720. https://doi.org/10.1128/AAC.01236-13