In Vitro efficacies and resistance profiles of rifampin-based combination regimens for biofilm-embedded methicillin-resistant Staphylococcus aureus

Hung Jen Tang, Chi Chung Chen, Kuo Chen Cheng, Kuan Ying Wu, Yi Chung Lin, Chun Cheng Zhang, Tzu Chieh Weng, Wen Liang Yu, Yu Hsin Chiu, Han Siong Toh, Shyh Ren Chiang, Bo An Su, Wen Chien Ko, Yin Ching Chuang

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

To compare the in vitro antibacterial efficacies and resistance profiles of rifampin-based combinations against methicillin-resistant Staphylococcus aureus (MRSA) in a biofilm model, the antibacterial activities of vancomycin, teicoplanin, daptomycin, minocycline, linezolid, fusidic acid, fosfomycin, and tigecycline alone or in combination with rifampin against biofilm-embedded MRSA were measured. The rifampin-resistant mutation frequencies were evaluated. Of the rifampin-based combinations, rifampin enhances the antibacterial activities of and even synergizes with fusidic acid, tigecycline, and, to a lesser extent, linezolid, fosfomycin, and minocycline against biofilm-embedded MRSA. Such combinations with weaker rifampin resistance induction activities may provide a therapeutic advantage in MRSA biofilm-related infections.

Original languageEnglish
Pages (from-to)5717-5720
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number11
DOIs
Publication statusPublished - Nov 2013
Externally publishedYes

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Rifampin
Methicillin-Resistant Staphylococcus aureus
Biofilms
Linezolid
Fusidic Acid
Fosfomycin
Minocycline
Daptomycin
Teicoplanin
Mutation Rate
Vancomycin
In Vitro Techniques
Infection

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

In Vitro efficacies and resistance profiles of rifampin-based combination regimens for biofilm-embedded methicillin-resistant Staphylococcus aureus. / Tang, Hung Jen; Chen, Chi Chung; Cheng, Kuo Chen; Wu, Kuan Ying; Lin, Yi Chung; Zhang, Chun Cheng; Weng, Tzu Chieh; Yu, Wen Liang; Chiu, Yu Hsin; Toh, Han Siong; Chiang, Shyh Ren; Su, Bo An; Ko, Wen Chien; Chuang, Yin Ching.

In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 11, 11.2013, p. 5717-5720.

Research output: Contribution to journalArticle

Tang, HJ, Chen, CC, Cheng, KC, Wu, KY, Lin, YC, Zhang, CC, Weng, TC, Yu, WL, Chiu, YH, Toh, HS, Chiang, SR, Su, BA, Ko, WC & Chuang, YC 2013, 'In Vitro efficacies and resistance profiles of rifampin-based combination regimens for biofilm-embedded methicillin-resistant Staphylococcus aureus', Antimicrobial Agents and Chemotherapy, vol. 57, no. 11, pp. 5717-5720. https://doi.org/10.1128/AAC.01236-13
Tang, Hung Jen ; Chen, Chi Chung ; Cheng, Kuo Chen ; Wu, Kuan Ying ; Lin, Yi Chung ; Zhang, Chun Cheng ; Weng, Tzu Chieh ; Yu, Wen Liang ; Chiu, Yu Hsin ; Toh, Han Siong ; Chiang, Shyh Ren ; Su, Bo An ; Ko, Wen Chien ; Chuang, Yin Ching. / In Vitro efficacies and resistance profiles of rifampin-based combination regimens for biofilm-embedded methicillin-resistant Staphylococcus aureus. In: Antimicrobial Agents and Chemotherapy. 2013 ; Vol. 57, No. 11. pp. 5717-5720.
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