In vitro diffusion of lidocaine across endotracheal tube cuffs

Chun Jen Huang, Ming Chuan Tsai, Chien Tsu Chen, Ching Rong Cheng, Kuo Hwa Wu, Tze Taur Wei

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose: Lidocaine diffuses across endotracheal tube cuffs, which may serve as a reservoir for local anesthetic to assist in the prevention of ETT- induced cough while emerging from general anesthesia. However, the rate of diffusion is slow. Two techniques, alkalization and warming, may increase the proportion of uncharged drug available for diffusion. The purpose of this study is to determine the effectiveness of warming alkalization or warming with alkalization on diffusion. Methods: Four preparations of lidocaine 4% were studied. Group (Gr) L -lidocaine (24°C), Gr WL - warmed lidocaine (38°C), Gr AL - alkalized lidocaine (24°C), Gr WAL - warmed, alkalized lidocaine (38°C). Twenty-four Mallinckrodt 8.0 ID (Mallinckrodt Critical Care Division of Mallinckrodt, Inc., Glens Falls, New York) endotracheal tube cuffs were filled with 6 ml of one of the four preparations. They were then placed in a 20 ml water bath at 38°C and samples were drawn from the water bath at intervals for up to 360 min. The lidocaine concentration in each sample was determined by gas chromatography. Results: The highest lidocaine concentration was reached in Gr WAL (410.98 ± 8.53 μg · ml-1) after 300 min and then decreased to 376.18 ± 4.59 μg · ml-1 after 360 min. In Gr AL the highest concentration (235.05 ± 2.99 μg · ml-1) was reached after 360 min. Lidocaine concentrations in Gr L and WL after 360 min were 3.19 ± 1.16 μg · ml-1 and 4.32 ± 2.02 μg · ml-1 respectively. Conclusion: Alkalization with or without warming, but not warming alone, promotes lidocaine diffusion from endotracheal tube cuff.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalCanadian Journal of Anesthesia
Volume46
Issue number1
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Lidocaine
Baths
In Vitro Techniques
Water
Critical Care
Local Anesthetics
Cough
Gas Chromatography
General Anesthesia

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Huang, C. J., Tsai, M. C., Chen, C. T., Cheng, C. R., Wu, K. H., & Wei, T. T. (1999). In vitro diffusion of lidocaine across endotracheal tube cuffs. Canadian Journal of Anesthesia, 46(1), 82-86.

In vitro diffusion of lidocaine across endotracheal tube cuffs. / Huang, Chun Jen; Tsai, Ming Chuan; Chen, Chien Tsu; Cheng, Ching Rong; Wu, Kuo Hwa; Wei, Tze Taur.

In: Canadian Journal of Anesthesia, Vol. 46, No. 1, 1999, p. 82-86.

Research output: Contribution to journalArticle

Huang, CJ, Tsai, MC, Chen, CT, Cheng, CR, Wu, KH & Wei, TT 1999, 'In vitro diffusion of lidocaine across endotracheal tube cuffs', Canadian Journal of Anesthesia, vol. 46, no. 1, pp. 82-86.
Huang, Chun Jen ; Tsai, Ming Chuan ; Chen, Chien Tsu ; Cheng, Ching Rong ; Wu, Kuo Hwa ; Wei, Tze Taur. / In vitro diffusion of lidocaine across endotracheal tube cuffs. In: Canadian Journal of Anesthesia. 1999 ; Vol. 46, No. 1. pp. 82-86.
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abstract = "Purpose: Lidocaine diffuses across endotracheal tube cuffs, which may serve as a reservoir for local anesthetic to assist in the prevention of ETT- induced cough while emerging from general anesthesia. However, the rate of diffusion is slow. Two techniques, alkalization and warming, may increase the proportion of uncharged drug available for diffusion. The purpose of this study is to determine the effectiveness of warming alkalization or warming with alkalization on diffusion. Methods: Four preparations of lidocaine 4{\%} were studied. Group (Gr) L -lidocaine (24°C), Gr WL - warmed lidocaine (38°C), Gr AL - alkalized lidocaine (24°C), Gr WAL - warmed, alkalized lidocaine (38°C). Twenty-four Mallinckrodt 8.0 ID (Mallinckrodt Critical Care Division of Mallinckrodt, Inc., Glens Falls, New York) endotracheal tube cuffs were filled with 6 ml of one of the four preparations. They were then placed in a 20 ml water bath at 38°C and samples were drawn from the water bath at intervals for up to 360 min. The lidocaine concentration in each sample was determined by gas chromatography. Results: The highest lidocaine concentration was reached in Gr WAL (410.98 ± 8.53 μg · ml-1) after 300 min and then decreased to 376.18 ± 4.59 μg · ml-1 after 360 min. In Gr AL the highest concentration (235.05 ± 2.99 μg · ml-1) was reached after 360 min. Lidocaine concentrations in Gr L and WL after 360 min were 3.19 ± 1.16 μg · ml-1 and 4.32 ± 2.02 μg · ml-1 respectively. Conclusion: Alkalization with or without warming, but not warming alone, promotes lidocaine diffusion from endotracheal tube cuff.",
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AU - Wu, Kuo Hwa

AU - Wei, Tze Taur

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AB - Purpose: Lidocaine diffuses across endotracheal tube cuffs, which may serve as a reservoir for local anesthetic to assist in the prevention of ETT- induced cough while emerging from general anesthesia. However, the rate of diffusion is slow. Two techniques, alkalization and warming, may increase the proportion of uncharged drug available for diffusion. The purpose of this study is to determine the effectiveness of warming alkalization or warming with alkalization on diffusion. Methods: Four preparations of lidocaine 4% were studied. Group (Gr) L -lidocaine (24°C), Gr WL - warmed lidocaine (38°C), Gr AL - alkalized lidocaine (24°C), Gr WAL - warmed, alkalized lidocaine (38°C). Twenty-four Mallinckrodt 8.0 ID (Mallinckrodt Critical Care Division of Mallinckrodt, Inc., Glens Falls, New York) endotracheal tube cuffs were filled with 6 ml of one of the four preparations. They were then placed in a 20 ml water bath at 38°C and samples were drawn from the water bath at intervals for up to 360 min. The lidocaine concentration in each sample was determined by gas chromatography. Results: The highest lidocaine concentration was reached in Gr WAL (410.98 ± 8.53 μg · ml-1) after 300 min and then decreased to 376.18 ± 4.59 μg · ml-1 after 360 min. In Gr AL the highest concentration (235.05 ± 2.99 μg · ml-1) was reached after 360 min. Lidocaine concentrations in Gr L and WL after 360 min were 3.19 ± 1.16 μg · ml-1 and 4.32 ± 2.02 μg · ml-1 respectively. Conclusion: Alkalization with or without warming, but not warming alone, promotes lidocaine diffusion from endotracheal tube cuff.

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