In vitro cell study of possible anti-inflammatory and pain relief mechanism of far-infrared ray-emitting ceramic material

Ting-Kai Leung, Yu Chuan Liu, Chien Ho Chen, Hsieh Nien-Fang, Kun Cho Chen, Chi-Ming Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Inflammation and pain are the major chronic symptoms in geriatric medicine. This study examines the possible mechanism of a far-infrared ray-emitting ceramic material (bioceramic) on these symptoms using cell models. Effective doses of lipopolysaccharides (LPS) were added to induce acute episodes of inflammation in murine macrophage (RAW 264.7) and human chondrosarcoma (SW1353) cells. The inducible nitric oxide synthetase (iNOS), cyclo-oxygenase-2 (COX-2), and prostaglandin E2 (PGE2) levels were determined for the cell lines. Biocermic treatment was found to have significant inhibitory effects on COX-2 and PGE2 and a probable effect on iNOS in the cell models of LPS-mediated inflammation. Bioceramic treatment may be an alternative method for palliative pain control to reduce chemical drug dependence for the protection of renal functions in the chronic pain disease population.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalJournal of Medical and Biological Engineering
Volume33
Issue number2
DOIs
Publication statusPublished - 2013

Keywords

  • Bone marrow stromal cells (BMSCs)
  • Collagen I nanospheres
  • Osteogenic differentiation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine(all)

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