Abstract

The aim of this study was to fabricate biodegradable poly-L-lactic acid (PLLA) bone screws containing iron oxide (Fe3O4) nanoparticles, which are radiopaque and 3D-printable. The PLLA composites were fabricated by loading 20%, 30%, and 40% Fe3O4 nanoparticles into the PLLA. The physical properties, including elastic modulus, thermal properties, and biocompatibility of the composites were tested. The 20% nano-Fe3O4/PLLA composite was used as the material for fabricating the 3D-printed bone screws. The mechanical performance of the nano-Fe3O4/PLLA bone screws was evaluated by anti-bending and anti-torque strength tests. The tissue response and radiopacity of the nano-Fe3O4/PLLA bone screws were assessed by histologic and CT imaging studies using an animal model. The addition of nano-Fe3O4 increased the crystallization of the PLLA composites. Furthermore, the 20% nano-Fe3O4/PLLA composite exhibited the highest thermal stability compared to the other Fe3O4 proportions. The 3D-printed bone screws using the 20% nano-Fe3O4/PLLA composite provided excellent local tissue response. In addition, the radiopacity of the 20% nano-Fe3O4/PLLA screw was significantly better compared with the neat PLLA screw.

Original languageEnglish
Article number191
JournalPolymers
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

Fingerprint

Lactic acid
Biocompatibility
Bone
Physical properties
Composite materials
poly(lactide)
poly(lactic acid)
Tissue
Nanoparticles
Crystallization
Iron oxides
Animals
Thermodynamic stability
Thermodynamic properties
Torque
Elastic moduli
Imaging techniques

Keywords

  • 3D printed bone screw
  • Iron oxide nanoparticles
  • Poly-L-lactic acid
  • Radiopaque polymer

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics

Cite this

In vitro biocompatibility, radiopacity, and physical property tests of nano-Fe3O4 incorporated poly-L-lactide bone screws. / Wang, Hsin Ta; Chiang, Pao Chang; Tzeng, Jy Jiunn; Wu, Ting Lin; Pan, Yu Hwa; Chang, Wei Jen; Huang, Haw Ming.

In: Polymers, Vol. 9, No. 6, 191, 01.06.2017.

Research output: Contribution to journalArticle

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abstract = "The aim of this study was to fabricate biodegradable poly-L-lactic acid (PLLA) bone screws containing iron oxide (Fe3O4) nanoparticles, which are radiopaque and 3D-printable. The PLLA composites were fabricated by loading 20{\%}, 30{\%}, and 40{\%} Fe3O4 nanoparticles into the PLLA. The physical properties, including elastic modulus, thermal properties, and biocompatibility of the composites were tested. The 20{\%} nano-Fe3O4/PLLA composite was used as the material for fabricating the 3D-printed bone screws. The mechanical performance of the nano-Fe3O4/PLLA bone screws was evaluated by anti-bending and anti-torque strength tests. The tissue response and radiopacity of the nano-Fe3O4/PLLA bone screws were assessed by histologic and CT imaging studies using an animal model. The addition of nano-Fe3O4 increased the crystallization of the PLLA composites. Furthermore, the 20{\%} nano-Fe3O4/PLLA composite exhibited the highest thermal stability compared to the other Fe3O4 proportions. The 3D-printed bone screws using the 20{\%} nano-Fe3O4/PLLA composite provided excellent local tissue response. In addition, the radiopacity of the 20{\%} nano-Fe3O4/PLLA screw was significantly better compared with the neat PLLA screw.",
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