In vitro anti-hepatoma activity of fifteen natural medicines from Canada

Liang Tzung Lin, Li Teh Liu, Lien Chai Chiang, Chun Ching Lin

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Fifteen crude drugs, Stellaria media Cyrill. (Caryophyllaceae), Calendula officinalis L. (Compositae), Achillea millefolium L. (Compositae), Verbascum thapsus L. (Scrophulariaceae), Plantago major L. (Plantaginaceae), Borago officinalis L. (Boraginaceae), Satureja hortensis L. (Labiatae), Coptis groenlandica Salisb. (Ranunculaceae), Cassia angustifolia Vahl. (Leguminosae), Origanum majorana L. (Labiatae), Centella asiatica L. (Umbelliferae), Caulophyllum thalictroides Mich. (Berberidaceae), Picea rubens Sargent. (Pinaceae), Rhamnus purshiana D.C. (Rhamnaceae) and Hibiscus sabdariffa L. (Malvaceae), which have been used as folk medicine in Canada, were evaluated for their anti-hepatoma activity on five human liver-cancer cell lines, i.e. HepG2/C3A, SK-HEP-1, HA22T/VGH, Hep3B and PLC/PRF/5. The samples were examined by in vitro evaluation for their cytotoxicity. The results showed that the effects of crude drugs on hepatitis B virus genome-containing cell lines were different from those against non hepatitis B virus genome-containing cell lines. C. groenlandica was observed to be the most effective against the growth of all five cell lines and its chemotherapeutic values will be of interest for further studies.

Original languageEnglish
Pages (from-to)440-444
Number of pages5
JournalPhytotherapy Research
Volume16
Issue number5
DOIs
Publication statusPublished - Aug 2002
Externally publishedYes

Fingerprint

Medicine
Canada
Hepatocellular Carcinoma
Cells
Lamiaceae
Cell Line
Asteraceae
Viruses
Hepatitis B virus
Caulophyllum
Berberidaceae
Stellaria
Verbascum
Rhamnus
Rhamnaceae
Senna Plant
Borago
Caryophyllaceae
Pinaceae
Coptis

Keywords

  • Anti-hepatoma activity
  • Canada
  • Crude drugs
  • HBV
  • Natural medicines
  • Tumour

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

In vitro anti-hepatoma activity of fifteen natural medicines from Canada. / Lin, Liang Tzung; Liu, Li Teh; Chiang, Lien Chai; Lin, Chun Ching.

In: Phytotherapy Research, Vol. 16, No. 5, 08.2002, p. 440-444.

Research output: Contribution to journalArticle

Lin, Liang Tzung ; Liu, Li Teh ; Chiang, Lien Chai ; Lin, Chun Ching. / In vitro anti-hepatoma activity of fifteen natural medicines from Canada. In: Phytotherapy Research. 2002 ; Vol. 16, No. 5. pp. 440-444.
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