In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age

Ching Chun Lin, Yu Chuan Chen, Feng Chiao Su, Chien Mu Lin, Hua Fang Liao, Yaw Huei Hwang, Wu Shiun Hsieh, Suh Fang Jeng, Yi Ning Su, Pau Chung Chen

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Abstract

Background and objective: Manganese, lead, arsenic and mercury are common neurotoxic metals in the environment. Nonetheless, the relationship between prenatal exposure to low doses of neurotoxic metals and neurodevelopment in children is not clear. The objective of this study was to explore the relationship between in utero exposure to environmental neurotoxic metals and neurodevelopment at 2 years of age. Methods: The population of this study came from the Taiwan Birth Panel Study. We included 230 pairs of non-smoking mothers without any occupational exposure and their singleton full-term children. The information about exposure during pregnancy was obtained using a structured questionnaire, and the manganese, lead, arsenic and mercury levels in umbilical cord blood samples were analyzed using inductively coupled plasma mass spectrometry. We used the Comprehensive Developmental Inventory for Infants and Toddlers (CDIIT) to evaluate the developmental status of each child at 2 years of age, and we examined the association of in utero exposure to environmental metals and neurodevelopment using linear regression models. Results: The median concentrations of manganese, lead, arsenic and mercury in the cord blood samples in this study were 47.90. μg/L (range, 17.88-106.85. μg/L), 11.41. μg/L (range 0.16-43.22. μg/L), 4.05. μg/L (range, 1.50-12.88. μg/L) and 12.17. μg/L (range, 1.53-64.87. μg/L), respectively. After adjusting for maternal age, infant gender, environmental tobacco smoke during pregnancy and after delivery, Home Observation for Measurement of the Environment Inventory results, and arsenic and mercury levels in cord blood, we found that manganese and lead levels above the 75th percentile had a significant adverse association with the overall (. β=-7.03, SE=2.65, P=0.0085), cognitive (. β=-8.19, SE=3.17, P=0.0105), and language quotients (. β=-6.81, SE=2.73, P=0.0133) of the CDIIT. Conclusions: In utero exposure to environmental manganese and lead may have an adverse association with neurodevelopment at 2 years of age, and there is an interaction effect between the manganese and lead levels in the cord blood that could aggravate the effect.

Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalEnvironmental Research
Volume123
DOIs
Publication statusPublished - May 1 2013

Fingerprint

Environmental Exposure
Manganese
manganese
Arsenic
Mercury
Fetal Blood
arsenic
Blood
blood
Metals
metal
pregnancy
Equipment and Supplies
Linear Models
Inductively coupled plasma mass spectrometry
Pregnancy
Tobacco
Maternal Age
occupational exposure
Occupational Exposure

Keywords

  • Children
  • In utero exposure
  • Neurodevelopment
  • Neurotoxic metals

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age. / Lin, Ching Chun; Chen, Yu Chuan; Su, Feng Chiao; Lin, Chien Mu; Liao, Hua Fang; Hwang, Yaw Huei; Hsieh, Wu Shiun; Jeng, Suh Fang; Su, Yi Ning; Chen, Pau Chung.

In: Environmental Research, Vol. 123, 01.05.2013, p. 52-57.

Research output: Contribution to journalArticle

Lin, CC, Chen, YC, Su, FC, Lin, CM, Liao, HF, Hwang, YH, Hsieh, WS, Jeng, SF, Su, YN & Chen, PC 2013, 'In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age', Environmental Research, vol. 123, pp. 52-57. https://doi.org/10.1016/j.envres.2013.03.003
Lin, Ching Chun ; Chen, Yu Chuan ; Su, Feng Chiao ; Lin, Chien Mu ; Liao, Hua Fang ; Hwang, Yaw Huei ; Hsieh, Wu Shiun ; Jeng, Suh Fang ; Su, Yi Ning ; Chen, Pau Chung. / In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age. In: Environmental Research. 2013 ; Vol. 123. pp. 52-57.
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abstract = "Background and objective: Manganese, lead, arsenic and mercury are common neurotoxic metals in the environment. Nonetheless, the relationship between prenatal exposure to low doses of neurotoxic metals and neurodevelopment in children is not clear. The objective of this study was to explore the relationship between in utero exposure to environmental neurotoxic metals and neurodevelopment at 2 years of age. Methods: The population of this study came from the Taiwan Birth Panel Study. We included 230 pairs of non-smoking mothers without any occupational exposure and their singleton full-term children. The information about exposure during pregnancy was obtained using a structured questionnaire, and the manganese, lead, arsenic and mercury levels in umbilical cord blood samples were analyzed using inductively coupled plasma mass spectrometry. We used the Comprehensive Developmental Inventory for Infants and Toddlers (CDIIT) to evaluate the developmental status of each child at 2 years of age, and we examined the association of in utero exposure to environmental metals and neurodevelopment using linear regression models. Results: The median concentrations of manganese, lead, arsenic and mercury in the cord blood samples in this study were 47.90. μg/L (range, 17.88-106.85. μg/L), 11.41. μg/L (range 0.16-43.22. μg/L), 4.05. μg/L (range, 1.50-12.88. μg/L) and 12.17. μg/L (range, 1.53-64.87. μg/L), respectively. After adjusting for maternal age, infant gender, environmental tobacco smoke during pregnancy and after delivery, Home Observation for Measurement of the Environment Inventory results, and arsenic and mercury levels in cord blood, we found that manganese and lead levels above the 75th percentile had a significant adverse association with the overall (. β=-7.03, SE=2.65, P=0.0085), cognitive (. β=-8.19, SE=3.17, P=0.0105), and language quotients (. β=-6.81, SE=2.73, P=0.0133) of the CDIIT. Conclusions: In utero exposure to environmental manganese and lead may have an adverse association with neurodevelopment at 2 years of age, and there is an interaction effect between the manganese and lead levels in the cord blood that could aggravate the effect.",
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AU - Chen, Yu Chuan

AU - Su, Feng Chiao

AU - Lin, Chien Mu

AU - Liao, Hua Fang

AU - Hwang, Yaw Huei

AU - Hsieh, Wu Shiun

AU - Jeng, Suh Fang

AU - Su, Yi Ning

AU - Chen, Pau Chung

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N2 - Background and objective: Manganese, lead, arsenic and mercury are common neurotoxic metals in the environment. Nonetheless, the relationship between prenatal exposure to low doses of neurotoxic metals and neurodevelopment in children is not clear. The objective of this study was to explore the relationship between in utero exposure to environmental neurotoxic metals and neurodevelopment at 2 years of age. Methods: The population of this study came from the Taiwan Birth Panel Study. We included 230 pairs of non-smoking mothers without any occupational exposure and their singleton full-term children. The information about exposure during pregnancy was obtained using a structured questionnaire, and the manganese, lead, arsenic and mercury levels in umbilical cord blood samples were analyzed using inductively coupled plasma mass spectrometry. We used the Comprehensive Developmental Inventory for Infants and Toddlers (CDIIT) to evaluate the developmental status of each child at 2 years of age, and we examined the association of in utero exposure to environmental metals and neurodevelopment using linear regression models. Results: The median concentrations of manganese, lead, arsenic and mercury in the cord blood samples in this study were 47.90. μg/L (range, 17.88-106.85. μg/L), 11.41. μg/L (range 0.16-43.22. μg/L), 4.05. μg/L (range, 1.50-12.88. μg/L) and 12.17. μg/L (range, 1.53-64.87. μg/L), respectively. After adjusting for maternal age, infant gender, environmental tobacco smoke during pregnancy and after delivery, Home Observation for Measurement of the Environment Inventory results, and arsenic and mercury levels in cord blood, we found that manganese and lead levels above the 75th percentile had a significant adverse association with the overall (. β=-7.03, SE=2.65, P=0.0085), cognitive (. β=-8.19, SE=3.17, P=0.0105), and language quotients (. β=-6.81, SE=2.73, P=0.0133) of the CDIIT. Conclusions: In utero exposure to environmental manganese and lead may have an adverse association with neurodevelopment at 2 years of age, and there is an interaction effect between the manganese and lead levels in the cord blood that could aggravate the effect.

AB - Background and objective: Manganese, lead, arsenic and mercury are common neurotoxic metals in the environment. Nonetheless, the relationship between prenatal exposure to low doses of neurotoxic metals and neurodevelopment in children is not clear. The objective of this study was to explore the relationship between in utero exposure to environmental neurotoxic metals and neurodevelopment at 2 years of age. Methods: The population of this study came from the Taiwan Birth Panel Study. We included 230 pairs of non-smoking mothers without any occupational exposure and their singleton full-term children. The information about exposure during pregnancy was obtained using a structured questionnaire, and the manganese, lead, arsenic and mercury levels in umbilical cord blood samples were analyzed using inductively coupled plasma mass spectrometry. We used the Comprehensive Developmental Inventory for Infants and Toddlers (CDIIT) to evaluate the developmental status of each child at 2 years of age, and we examined the association of in utero exposure to environmental metals and neurodevelopment using linear regression models. Results: The median concentrations of manganese, lead, arsenic and mercury in the cord blood samples in this study were 47.90. μg/L (range, 17.88-106.85. μg/L), 11.41. μg/L (range 0.16-43.22. μg/L), 4.05. μg/L (range, 1.50-12.88. μg/L) and 12.17. μg/L (range, 1.53-64.87. μg/L), respectively. After adjusting for maternal age, infant gender, environmental tobacco smoke during pregnancy and after delivery, Home Observation for Measurement of the Environment Inventory results, and arsenic and mercury levels in cord blood, we found that manganese and lead levels above the 75th percentile had a significant adverse association with the overall (. β=-7.03, SE=2.65, P=0.0085), cognitive (. β=-8.19, SE=3.17, P=0.0105), and language quotients (. β=-6.81, SE=2.73, P=0.0133) of the CDIIT. Conclusions: In utero exposure to environmental manganese and lead may have an adverse association with neurodevelopment at 2 years of age, and there is an interaction effect between the manganese and lead levels in the cord blood that could aggravate the effect.

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