In situ detection of Epstein-Barr virus in breast cancer

Jan Show Chu, Chung Chung Chen, King Jen Chang

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) is strongly associated with nasopharyngeal carcinoma and some lymphoepithelioma-like carcinomas from other anatomic sites. This study investigates the presence of EBV in breast cancer. Immunohistochemistry for EBV proteins (EBV nuclear antigen-2 and latent membrane protein-1) and in situ hybridization for EBV-encoded small nuclear RNAs (EBER-1 and -2) were performed in 60 invasive breast cancers. None of the 60 breast cancer samples showed detectable EBV. These results suggest that EBV may not play a significant role in the etiology of breast cancers in Taiwan.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalCancer Letters
Volume124
Issue number1
DOIs
Publication statusPublished - Feb 13 1998
Externally publishedYes

Keywords

  • Breast cancer
  • Epstein-Barr virus
  • Immunohistochemistry
  • In situ hybridization

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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