Improving the safety of tolerance induction: Chimerism and cellular co-treatment strategies applied to vascularized composite allografts

Wei Chao Huang, Jeng Yee Lin, Christopher Glenn Wallace, Fu Chan Wei, Shuen Kuei Liao

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Although vascularized composite allografts (VCAs) have been performed clinically for a variety of indications, potential complications from long-term immunosuppression and graft-versus-host disease remain important barriers to widespread applications. Recently it has been demonstrated that VCAs incorporating a vascularized long bone in a rat model provide concurrent vascularized bone marrow transplantation that, itself, functions to establish hematopoietic chimerism and donor-specific tolerance following non-myeloablative conditioning of recipients. Advances such as this, which aim to improve the safety profile of tolerance induction, will help usher in an era of wider clinical VCA application for nonlife-saving reconstructions.

Original languageEnglish
Article number107901
JournalClinical and Developmental Immunology
Volume2012
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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