Improving abnormal hemorheological parameters in aging guinea pigs by water-soluble extracts of Salvia miltiorrhiza Bunge

Wen Chi Hou, Hsin Sheng Tsay, Hong Jen Liang, Tzung Yan Lee, Guei Jane Wang, Der Zen Liu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Salvia miltiorrhiza Bunge, known as Danshen in Chinese traditional medicine is effective at promoting blood circulation and removing (or decreasing) blood stasis. In the present study, we selected aging, 24-month-old guinea pigs as the animal experimental models and fed them a diet containing 75, 100 or 150 mg/(kg day) of water-soluble extract components of Salvia miltiorrhiza Bunge (WSm) for 28 days, respectively, in order to evaluate the effects of WSm on their abnormal hemorheological parameters. The results showed that the blood biochemical parameters of the aging guinea pigs remained unaffected by orally given WSm compared to the controls, except that the fibrinogen levels of the group fed the high dose of WSm (150 mg/(kg day)) decreased. Aging guinea pigs fed a low dose of WSm (75 mg/(kg day)) showed no significant difference in hemorheological parameters. However, feeding of WSm at 100 mg/(kg day) (medium dose), significantly reduced erythrocyte membrane MDA levels, which probably increased erythrocyte deformability and decreased erythrocyte flow resistance, though no improvement in erythrocyte aggregation, blood viscosity, and blood viscoelasticity could be observed. Furthermore, when the dose reached 150 mg/(kg day) of WSm (high dose), a significant decrease in whole blood viscosity was observed at high, medium and low shear rates. Blood viscosity and viscoelasticity exhibited significant improvement in oscillatory measurements. Also, we found that the oxygen transport efficiency of whole blood increased.

Original languageEnglish
Pages (from-to)483-489
Number of pages7
JournalJournal of Ethnopharmacology
Volume111
Issue number3
DOIs
Publication statusPublished - May 22 2007

Fingerprint

Salvia miltiorrhiza
Blood Viscosity
Guinea Pigs
Water
Erythrocyte Aggregation
Erythrocyte Deformability
Blood Circulation
Chinese Traditional Medicine
Erythrocyte Membrane
Fibrinogen
Animal Models
Erythrocytes
Oxygen
Diet

Keywords

  • Aging
  • Blood viscosity
  • Danshen
  • Erythrocyte deformability
  • Salvia miltiorrhiza

ASJC Scopus subject areas

  • Pharmacology

Cite this

Improving abnormal hemorheological parameters in aging guinea pigs by water-soluble extracts of Salvia miltiorrhiza Bunge. / Hou, Wen Chi; Tsay, Hsin Sheng; Liang, Hong Jen; Lee, Tzung Yan; Wang, Guei Jane; Liu, Der Zen.

In: Journal of Ethnopharmacology, Vol. 111, No. 3, 22.05.2007, p. 483-489.

Research output: Contribution to journalArticle

Hou, Wen Chi ; Tsay, Hsin Sheng ; Liang, Hong Jen ; Lee, Tzung Yan ; Wang, Guei Jane ; Liu, Der Zen. / Improving abnormal hemorheological parameters in aging guinea pigs by water-soluble extracts of Salvia miltiorrhiza Bunge. In: Journal of Ethnopharmacology. 2007 ; Vol. 111, No. 3. pp. 483-489.
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