Improvement of bone-tendon fixation by porous titanium interference screw

A rabbit animal model

Pei I. Tsai, Chih Yu Chen, Shu Wei Huang, Kuo Yi Yang, Tzu Hung Lin, San Yuan Chen, Jui Sheng Sun

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The interference screw is a widely used fixation device in the anterior cruciate ligament (ACL) reconstruction surgeries. Despite the generally satisfactory results, problems of using interference screws were reported. By using additive manufacturing (AM) technology, we developed an innovative titanium alloy (Ti6Al4V) interference screw with rough surface and inter-connected porous structure designs to improve the bone-tendon fixation. An innovative Ti6Al4V interference screws were manufactured by AM technology. In vitro mechanical tests were performed to validate its mechanical properties. Twenty-seven New Zealand white rabbits were randomly divided into control and AM screw groups for biomechanical analyses and histological analysis at 4, 8, and 12 weeks postoperatively; while micro-CT analysis was performed at 12 weeks postoperatively. The biomechanical tests showed that the ultimate failure load in the AM interference screw group was significantly higher than that in the control group at all tested periods. These results were also compatible with the findings of micro-CT and histological analyses. In micro-CT analysis, the bone-screw gap was larger in the control group; while for the additive manufactured screw, the screw and bone growth was in close contact. In histological study, the bone-screw gaps were wider in the control group and were almost invisible in the AM screw group. The innovative AM interference screws with surface roughness and inter-connected porous architectures demonstrated better bone-tendon-implant integration, and resulted in stronger biomechanical characteristics when compared to traditional screws. These advantages can be transferred to future interference screw designs to improve their clinical performance. The AM interference screw could improve graft fixation and eventually result in better biomechanical performance of the bone-tendon-screw construct. The innovative AM interference screws can be transferred to future interference screw designs to improve the performance of implants.

Original languageEnglish
Pages (from-to)2633-2640
Number of pages8
JournalJournal of Orthopaedic Research
Volume36
Issue number10
DOIs
Publication statusPublished - Oct 1 2018

Fingerprint

Bone Screws
Titanium
Tendons
Animal Models
Rabbits
Bone and Bones
Control Groups
Technology
Anterior Cruciate Ligament Reconstruction
Bone Development
Transplants
Equipment and Supplies
titanium alloy (TiAl6V4)

Keywords

  • additive manufacturing
  • animal studies
  • bone-tendon interface
  • interference screw
  • Ti-alloy implants

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Improvement of bone-tendon fixation by porous titanium interference screw : A rabbit animal model. / Tsai, Pei I.; Chen, Chih Yu; Huang, Shu Wei; Yang, Kuo Yi; Lin, Tzu Hung; Chen, San Yuan; Sun, Jui Sheng.

In: Journal of Orthopaedic Research, Vol. 36, No. 10, 01.10.2018, p. 2633-2640.

Research output: Contribution to journalArticle

Tsai, Pei I. ; Chen, Chih Yu ; Huang, Shu Wei ; Yang, Kuo Yi ; Lin, Tzu Hung ; Chen, San Yuan ; Sun, Jui Sheng. / Improvement of bone-tendon fixation by porous titanium interference screw : A rabbit animal model. In: Journal of Orthopaedic Research. 2018 ; Vol. 36, No. 10. pp. 2633-2640.
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