Improved lung compliance following indomethacin therapy in premature infants with persistent ductus arteriosus

T. F. Yeh, A. Thalji, L. Luken, L. Lilien, I. Carr, R. S. Pildes

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

In the course of a double-blind controlled study of intra-venous indomethacin therapy in premature infants with patent ductus arteriosus (PDA), dynamic lung compliance (CL) was determined in 11 infants (six control, five indomethacin) who were not on assisted ventilation during the study period. The clinical, biochemical and laboratory data before the study were comparable between the groups. Following therapy with indomethacin, there was a significant decrease in left atrial/aortic root ratio (LA/Ao), left ventricular end-diastolic dimension (LVEDD) on echocardiogram, and an increase in tidal volume (V(T)) and C(L). In the control group, these variables did not change significantly. The improved lung compliance following early indomethacin closure of PDA may alter the clinical course and outcome of these premature infants.

Original languageEnglish
Pages (from-to)698-700
Number of pages3
JournalChest
Volume80
Issue number6
DOIs
Publication statusPublished - Jan 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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