Improved haemorrheological properties by Ginkgo biloba extract (Egb 761) in type 2 diabetes mellitus complicated with retinopathy

Shih Yi Huang, Chii Jeng, Shou Chuan Kao, Joseth Jy Hau Yu, Der Zen Liu

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background & Aims: Abnormal haemorrheological property changes in erythrocyte deformability, plasma and blood viscosity, and blood viscoelasticity may play very important roles in the development of microangiopathies in diabetes mellitus (DM). In this study, we demonstrate the improvement in abnormal haemorrheological parameters in DM with ingestion of Ginkgo biloba extract 761 (Egb 761). Methods: Haemorrheological parameters before and 3 months after Egb 761 oral ingestion were determined in 25 type 2 DM patients with retinopathy. These parameters included lipid peroxidation stress of erythrocytes, erythrocyte deformability, plasma and blood viscosity, blood viscoelasticity, and retinal capillary blood flow velocity. Results: After taking Egb 761 orally for 3 months, the blood viscosity was significantly reduced at different shear rates, by 0.44±0.10 (γ=400), 0.52±0.09 (γ=150) and 2.88±0.57 (γ=5). Viscoelasticity was significantly reduced in diabetic patients by 3.08±0.78 (0.1 Hz). The level of erythrocyte malondialdehyde (MDA) was reduced by 30%; however, the deformability of erythrocyte was increased by 20%. And lastly, retinal capillary blood flow rate was increased from 3.23±0.12 to 3.67±0.24 cm min-1. Conclusion: In this preliminary clinical study, 3 months of oral administration of Egb 761 significantly reduced MDA levels of erythrocytes membranes, decreased fibrinogen levels, promoted erythrocytes deformability, and improved blood viscosity and viscoelasticity, which may facilitate blood perfusion. Furthermore, it effectively improved retinal capillary blood flow rate in type 2 diabetic patients with retinopathy.

Original languageEnglish
Pages (from-to)615-621
Number of pages7
JournalClinical Nutrition
Volume23
Issue number4
DOIs
Publication statusPublished - Aug 2004

Fingerprint

Erythrocyte Deformability
Blood Viscosity
Type 2 Diabetes Mellitus
Malondialdehyde
Diabetes Mellitus
Eating
Erythrocytes
Blood Flow Velocity
Erythrocyte Membrane
Fibrinogen
Lipid Peroxidation
Oral Administration
Perfusion
Ginkgo biloba extract 761

Keywords

  • Blood viscoelasticity
  • Diabetes mellitus
  • Ginkgo biloba extract
  • Lipid peroxidation
  • Oscillation
  • Retinal capillary blood flow

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Endocrinology, Diabetes and Metabolism
  • Gastroenterology
  • Health Professions(all)
  • Medicine (miscellaneous)

Cite this

Improved haemorrheological properties by Ginkgo biloba extract (Egb 761) in type 2 diabetes mellitus complicated with retinopathy. / Huang, Shih Yi; Jeng, Chii; Kao, Shou Chuan; Yu, Joseth Jy Hau; Liu, Der Zen.

In: Clinical Nutrition, Vol. 23, No. 4, 08.2004, p. 615-621.

Research output: Contribution to journalArticle

@article{e83100da50974d43a6abf1a21a9b2fc4,
title = "Improved haemorrheological properties by Ginkgo biloba extract (Egb 761) in type 2 diabetes mellitus complicated with retinopathy",
abstract = "Background & Aims: Abnormal haemorrheological property changes in erythrocyte deformability, plasma and blood viscosity, and blood viscoelasticity may play very important roles in the development of microangiopathies in diabetes mellitus (DM). In this study, we demonstrate the improvement in abnormal haemorrheological parameters in DM with ingestion of Ginkgo biloba extract 761 (Egb 761). Methods: Haemorrheological parameters before and 3 months after Egb 761 oral ingestion were determined in 25 type 2 DM patients with retinopathy. These parameters included lipid peroxidation stress of erythrocytes, erythrocyte deformability, plasma and blood viscosity, blood viscoelasticity, and retinal capillary blood flow velocity. Results: After taking Egb 761 orally for 3 months, the blood viscosity was significantly reduced at different shear rates, by 0.44±0.10 (γ=400), 0.52±0.09 (γ=150) and 2.88±0.57 (γ=5). Viscoelasticity was significantly reduced in diabetic patients by 3.08±0.78 (0.1 Hz). The level of erythrocyte malondialdehyde (MDA) was reduced by 30{\%}; however, the deformability of erythrocyte was increased by 20{\%}. And lastly, retinal capillary blood flow rate was increased from 3.23±0.12 to 3.67±0.24 cm min-1. Conclusion: In this preliminary clinical study, 3 months of oral administration of Egb 761 significantly reduced MDA levels of erythrocytes membranes, decreased fibrinogen levels, promoted erythrocytes deformability, and improved blood viscosity and viscoelasticity, which may facilitate blood perfusion. Furthermore, it effectively improved retinal capillary blood flow rate in type 2 diabetic patients with retinopathy.",
keywords = "Blood viscoelasticity, Diabetes mellitus, Ginkgo biloba extract, Lipid peroxidation, Oscillation, Retinal capillary blood flow",
author = "Huang, {Shih Yi} and Chii Jeng and Kao, {Shou Chuan} and Yu, {Joseth Jy Hau} and Liu, {Der Zen}",
year = "2004",
month = "8",
doi = "10.1016/j.clnu.2003.10.010",
language = "English",
volume = "23",
pages = "615--621",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Churchill Livingstone",
number = "4",

}

TY - JOUR

T1 - Improved haemorrheological properties by Ginkgo biloba extract (Egb 761) in type 2 diabetes mellitus complicated with retinopathy

AU - Huang, Shih Yi

AU - Jeng, Chii

AU - Kao, Shou Chuan

AU - Yu, Joseth Jy Hau

AU - Liu, Der Zen

PY - 2004/8

Y1 - 2004/8

N2 - Background & Aims: Abnormal haemorrheological property changes in erythrocyte deformability, plasma and blood viscosity, and blood viscoelasticity may play very important roles in the development of microangiopathies in diabetes mellitus (DM). In this study, we demonstrate the improvement in abnormal haemorrheological parameters in DM with ingestion of Ginkgo biloba extract 761 (Egb 761). Methods: Haemorrheological parameters before and 3 months after Egb 761 oral ingestion were determined in 25 type 2 DM patients with retinopathy. These parameters included lipid peroxidation stress of erythrocytes, erythrocyte deformability, plasma and blood viscosity, blood viscoelasticity, and retinal capillary blood flow velocity. Results: After taking Egb 761 orally for 3 months, the blood viscosity was significantly reduced at different shear rates, by 0.44±0.10 (γ=400), 0.52±0.09 (γ=150) and 2.88±0.57 (γ=5). Viscoelasticity was significantly reduced in diabetic patients by 3.08±0.78 (0.1 Hz). The level of erythrocyte malondialdehyde (MDA) was reduced by 30%; however, the deformability of erythrocyte was increased by 20%. And lastly, retinal capillary blood flow rate was increased from 3.23±0.12 to 3.67±0.24 cm min-1. Conclusion: In this preliminary clinical study, 3 months of oral administration of Egb 761 significantly reduced MDA levels of erythrocytes membranes, decreased fibrinogen levels, promoted erythrocytes deformability, and improved blood viscosity and viscoelasticity, which may facilitate blood perfusion. Furthermore, it effectively improved retinal capillary blood flow rate in type 2 diabetic patients with retinopathy.

AB - Background & Aims: Abnormal haemorrheological property changes in erythrocyte deformability, plasma and blood viscosity, and blood viscoelasticity may play very important roles in the development of microangiopathies in diabetes mellitus (DM). In this study, we demonstrate the improvement in abnormal haemorrheological parameters in DM with ingestion of Ginkgo biloba extract 761 (Egb 761). Methods: Haemorrheological parameters before and 3 months after Egb 761 oral ingestion were determined in 25 type 2 DM patients with retinopathy. These parameters included lipid peroxidation stress of erythrocytes, erythrocyte deformability, plasma and blood viscosity, blood viscoelasticity, and retinal capillary blood flow velocity. Results: After taking Egb 761 orally for 3 months, the blood viscosity was significantly reduced at different shear rates, by 0.44±0.10 (γ=400), 0.52±0.09 (γ=150) and 2.88±0.57 (γ=5). Viscoelasticity was significantly reduced in diabetic patients by 3.08±0.78 (0.1 Hz). The level of erythrocyte malondialdehyde (MDA) was reduced by 30%; however, the deformability of erythrocyte was increased by 20%. And lastly, retinal capillary blood flow rate was increased from 3.23±0.12 to 3.67±0.24 cm min-1. Conclusion: In this preliminary clinical study, 3 months of oral administration of Egb 761 significantly reduced MDA levels of erythrocytes membranes, decreased fibrinogen levels, promoted erythrocytes deformability, and improved blood viscosity and viscoelasticity, which may facilitate blood perfusion. Furthermore, it effectively improved retinal capillary blood flow rate in type 2 diabetic patients with retinopathy.

KW - Blood viscoelasticity

KW - Diabetes mellitus

KW - Ginkgo biloba extract

KW - Lipid peroxidation

KW - Oscillation

KW - Retinal capillary blood flow

UR - http://www.scopus.com/inward/record.url?scp=4243068584&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4243068584&partnerID=8YFLogxK

U2 - 10.1016/j.clnu.2003.10.010

DO - 10.1016/j.clnu.2003.10.010

M3 - Article

VL - 23

SP - 615

EP - 621

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 4

ER -