Implications of salivary proteomics in drug discovery and development: a focus on cancer drug discovery

Shen Hu, Yun Yen, David Ann, David T. Wong

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Human saliva proteomics has proven to be a novel approach in the search for protein biomarkers for non-invasive detection of human cancers. This approach may also have implications within the process of anti-cancer drug discovery. Information from saliva proteomic measurements may contribute to the target discovery and validation, assessment of efficacy and toxicity of candidate drugs, identification of disease subgroups, and prediction of responses of individual patients. In this article, we aim to give a brief overview on human saliva proteome analysis, as well as its applications to cancer biomarker discovery. Potential applications of saliva proteomics in anticancer drug discovery and development will also be discussed.

Original languageEnglish
Pages (from-to)911-916
Number of pages6
JournalDrug Discovery Today
Volume12
Issue number21-22
DOIs
Publication statusPublished - Nov 1 2007
Externally publishedYes

Fingerprint

Drug Discovery
Saliva
Proteomics
Neoplasms
Proteome
Tumor Biomarkers
Drug-Related Side Effects and Adverse Reactions
Biomarkers
Proteins

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Implications of salivary proteomics in drug discovery and development : a focus on cancer drug discovery. / Hu, Shen; Yen, Yun; Ann, David; Wong, David T.

In: Drug Discovery Today, Vol. 12, No. 21-22, 01.11.2007, p. 911-916.

Research output: Contribution to journalReview article

@article{456f206d4bc348e7931b461c4adde0f7,
title = "Implications of salivary proteomics in drug discovery and development: a focus on cancer drug discovery",
abstract = "Human saliva proteomics has proven to be a novel approach in the search for protein biomarkers for non-invasive detection of human cancers. This approach may also have implications within the process of anti-cancer drug discovery. Information from saliva proteomic measurements may contribute to the target discovery and validation, assessment of efficacy and toxicity of candidate drugs, identification of disease subgroups, and prediction of responses of individual patients. In this article, we aim to give a brief overview on human saliva proteome analysis, as well as its applications to cancer biomarker discovery. Potential applications of saliva proteomics in anticancer drug discovery and development will also be discussed.",
author = "Shen Hu and Yun Yen and David Ann and Wong, {David T.}",
year = "2007",
month = "11",
day = "1",
doi = "10.1016/j.drudis.2007.08.008",
language = "English",
volume = "12",
pages = "911--916",
journal = "Drug Discovery Today",
issn = "1359-6446",
publisher = "Elsevier Limited",
number = "21-22",

}

TY - JOUR

T1 - Implications of salivary proteomics in drug discovery and development

T2 - a focus on cancer drug discovery

AU - Hu, Shen

AU - Yen, Yun

AU - Ann, David

AU - Wong, David T.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Human saliva proteomics has proven to be a novel approach in the search for protein biomarkers for non-invasive detection of human cancers. This approach may also have implications within the process of anti-cancer drug discovery. Information from saliva proteomic measurements may contribute to the target discovery and validation, assessment of efficacy and toxicity of candidate drugs, identification of disease subgroups, and prediction of responses of individual patients. In this article, we aim to give a brief overview on human saliva proteome analysis, as well as its applications to cancer biomarker discovery. Potential applications of saliva proteomics in anticancer drug discovery and development will also be discussed.

AB - Human saliva proteomics has proven to be a novel approach in the search for protein biomarkers for non-invasive detection of human cancers. This approach may also have implications within the process of anti-cancer drug discovery. Information from saliva proteomic measurements may contribute to the target discovery and validation, assessment of efficacy and toxicity of candidate drugs, identification of disease subgroups, and prediction of responses of individual patients. In this article, we aim to give a brief overview on human saliva proteome analysis, as well as its applications to cancer biomarker discovery. Potential applications of saliva proteomics in anticancer drug discovery and development will also be discussed.

UR - http://www.scopus.com/inward/record.url?scp=35748935209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35748935209&partnerID=8YFLogxK

U2 - 10.1016/j.drudis.2007.08.008

DO - 10.1016/j.drudis.2007.08.008

M3 - Review article

C2 - 17993408

AN - SCOPUS:35748935209

VL - 12

SP - 911

EP - 916

JO - Drug Discovery Today

JF - Drug Discovery Today

SN - 1359-6446

IS - 21-22

ER -