Implications of salivary proteomics in drug discovery and development: a focus on cancer drug discovery

Shen Hu, Yun Yen, David Ann, David T. Wong

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Human saliva proteomics has proven to be a novel approach in the search for protein biomarkers for non-invasive detection of human cancers. This approach may also have implications within the process of anti-cancer drug discovery. Information from saliva proteomic measurements may contribute to the target discovery and validation, assessment of efficacy and toxicity of candidate drugs, identification of disease subgroups, and prediction of responses of individual patients. In this article, we aim to give a brief overview on human saliva proteome analysis, as well as its applications to cancer biomarker discovery. Potential applications of saliva proteomics in anticancer drug discovery and development will also be discussed.

Original languageEnglish
Pages (from-to)911-916
Number of pages6
JournalDrug Discovery Today
Volume12
Issue number21-22
DOIs
Publication statusPublished - Nov 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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