Implication for second primary cancer from visible oral and oropharyngeal premalignant lesions in betel-nut chewing related oral cancer

Shyun Yu Liu, I. Jung Feng, Yu Wei Wu, Ching Yuan Chen, Chao Nan Hsiung, Hsueh Wei Chang, Che Yi Lin, Min Te Chang, Hsi Chien Yu, Sheng Yang Lee, Ching Yu Yen

Research output: Contribution to journalArticle

Abstract

Background: Visible oral and oropharyngeal premalignant lesions may be used to monitor for a second primary oral cancer. To control for bias, we focused on the visible oral and oropharyngeal premalignant lesions of patients with oral cancer with a positive betel-nut chewing habit. Visible oral and oropharyngeal premalignant lesions that can predict second primary oral cancers were studied. Methods: Nine hundred ninety-seven patients with positive betel-nut chewing habits and oral cancer were enrolled in this retrospective cohort study. We analyzed the relevance of their visible oral and oropharyngeal premalignant lesion incidence and relative clinicopathological variables to the development of a second primary oral cancer. Results: Second primary oral cancer risk was significantly higher in patients with positive visible oral and oropharyngeal premalignant lesions (P <.0001), especially in younger patients (P =.0023; ≤40 years: adjusted odds ratio [OR] 2.66; 40-60 years: adjusted OR 2.61). The heterogeneous leukoplakia was (adjusted OR 2.17) higher than homogeneous leukoplakia. Conclusion: The predictive value and practicality of visible oral and oropharyngeal premalignant lesions make it a potentially valuable marker in follow-ups of patients with a positive betel-nut chewing habit with oral cancer, especially young patients with heterogeneous leukoplakia.

Original languageEnglish
Pages (from-to)1428-1435
Number of pages8
JournalHead and Neck
Volume39
Issue number7
DOIs
Publication statusPublished - Jul 1 2017

Fingerprint

Areca
Second Primary Neoplasms
Mouth Neoplasms
Mastication
Leukoplakia
Habits
Odds Ratio
Cohort Studies
Retrospective Studies
Incidence

Keywords

  • erythroplakia
  • leukoplakia
  • oral and oropharyngeal
  • premalignant lesion
  • second primary oral cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Implication for second primary cancer from visible oral and oropharyngeal premalignant lesions in betel-nut chewing related oral cancer. / Liu, Shyun Yu; Feng, I. Jung; Wu, Yu Wei; Chen, Ching Yuan; Hsiung, Chao Nan; Chang, Hsueh Wei; Lin, Che Yi; Chang, Min Te; Yu, Hsi Chien; Lee, Sheng Yang; Yen, Ching Yu.

In: Head and Neck, Vol. 39, No. 7, 01.07.2017, p. 1428-1435.

Research output: Contribution to journalArticle

Liu, Shyun Yu ; Feng, I. Jung ; Wu, Yu Wei ; Chen, Ching Yuan ; Hsiung, Chao Nan ; Chang, Hsueh Wei ; Lin, Che Yi ; Chang, Min Te ; Yu, Hsi Chien ; Lee, Sheng Yang ; Yen, Ching Yu. / Implication for second primary cancer from visible oral and oropharyngeal premalignant lesions in betel-nut chewing related oral cancer. In: Head and Neck. 2017 ; Vol. 39, No. 7. pp. 1428-1435.
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abstract = "Background: Visible oral and oropharyngeal premalignant lesions may be used to monitor for a second primary oral cancer. To control for bias, we focused on the visible oral and oropharyngeal premalignant lesions of patients with oral cancer with a positive betel-nut chewing habit. Visible oral and oropharyngeal premalignant lesions that can predict second primary oral cancers were studied. Methods: Nine hundred ninety-seven patients with positive betel-nut chewing habits and oral cancer were enrolled in this retrospective cohort study. We analyzed the relevance of their visible oral and oropharyngeal premalignant lesion incidence and relative clinicopathological variables to the development of a second primary oral cancer. Results: Second primary oral cancer risk was significantly higher in patients with positive visible oral and oropharyngeal premalignant lesions (P <.0001), especially in younger patients (P =.0023; ≤40 years: adjusted odds ratio [OR] 2.66; 40-60 years: adjusted OR 2.61). The heterogeneous leukoplakia was (adjusted OR 2.17) higher than homogeneous leukoplakia. Conclusion: The predictive value and practicality of visible oral and oropharyngeal premalignant lesions make it a potentially valuable marker in follow-ups of patients with a positive betel-nut chewing habit with oral cancer, especially young patients with heterogeneous leukoplakia.",
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AU - Liu, Shyun Yu

AU - Feng, I. Jung

AU - Wu, Yu Wei

AU - Chen, Ching Yuan

AU - Hsiung, Chao Nan

AU - Chang, Hsueh Wei

AU - Lin, Che Yi

AU - Chang, Min Te

AU - Yu, Hsi Chien

AU - Lee, Sheng Yang

AU - Yen, Ching Yu

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N2 - Background: Visible oral and oropharyngeal premalignant lesions may be used to monitor for a second primary oral cancer. To control for bias, we focused on the visible oral and oropharyngeal premalignant lesions of patients with oral cancer with a positive betel-nut chewing habit. Visible oral and oropharyngeal premalignant lesions that can predict second primary oral cancers were studied. Methods: Nine hundred ninety-seven patients with positive betel-nut chewing habits and oral cancer were enrolled in this retrospective cohort study. We analyzed the relevance of their visible oral and oropharyngeal premalignant lesion incidence and relative clinicopathological variables to the development of a second primary oral cancer. Results: Second primary oral cancer risk was significantly higher in patients with positive visible oral and oropharyngeal premalignant lesions (P <.0001), especially in younger patients (P =.0023; ≤40 years: adjusted odds ratio [OR] 2.66; 40-60 years: adjusted OR 2.61). The heterogeneous leukoplakia was (adjusted OR 2.17) higher than homogeneous leukoplakia. Conclusion: The predictive value and practicality of visible oral and oropharyngeal premalignant lesions make it a potentially valuable marker in follow-ups of patients with a positive betel-nut chewing habit with oral cancer, especially young patients with heterogeneous leukoplakia.

AB - Background: Visible oral and oropharyngeal premalignant lesions may be used to monitor for a second primary oral cancer. To control for bias, we focused on the visible oral and oropharyngeal premalignant lesions of patients with oral cancer with a positive betel-nut chewing habit. Visible oral and oropharyngeal premalignant lesions that can predict second primary oral cancers were studied. Methods: Nine hundred ninety-seven patients with positive betel-nut chewing habits and oral cancer were enrolled in this retrospective cohort study. We analyzed the relevance of their visible oral and oropharyngeal premalignant lesion incidence and relative clinicopathological variables to the development of a second primary oral cancer. Results: Second primary oral cancer risk was significantly higher in patients with positive visible oral and oropharyngeal premalignant lesions (P <.0001), especially in younger patients (P =.0023; ≤40 years: adjusted odds ratio [OR] 2.66; 40-60 years: adjusted OR 2.61). The heterogeneous leukoplakia was (adjusted OR 2.17) higher than homogeneous leukoplakia. Conclusion: The predictive value and practicality of visible oral and oropharyngeal premalignant lesions make it a potentially valuable marker in follow-ups of patients with a positive betel-nut chewing habit with oral cancer, especially young patients with heterogeneous leukoplakia.

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