Impairment of the atrial substrates by chronic cigarette smoking in patients with atrial fibrillation

Ta Chuan Tuan, Shih Lin Chang, Ching Tai Tai, Yenn Jiang Lin, Yu Feng Hu, Li Wei Lo, Wanwarang Wongcharoen, Ameya R. Udyavar, Shuo Ju Chiang, Yi Jen Chen, Hsuan Ming Tsao, Kwo Chang Ueng, Shih Ann Chen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Smoking, Voltage, and Atrial Fibrillation. Background: Smoking is a major risk factor for cardiovascular disease. The impact of smoking on the right and left atrial substrates is unknown. Methods: This study included 88 patients (age 50 ± 13 years, M/F = 71/17) who underwent four pulmonary veins isolation (PVI) for paroxysmal atrial fibrillation (AF). The mean voltage and total activation time of the individual atria were obtained by using a NavX mapping system, and were compared between the patients with and without a previous smoking history. The dose effect was evaluated by the smoking intensity-duration, defined as the number of packs per day plus how many years they had been smoking. Results: The right atrial (RA) mean voltage was lower in the patients with a previous history of smoking than in those without a history of smoking (1.92 ± 0.49 vs 2.17 ± 0.56 mV, P <0.05). The left atrial (LA) mean voltage was similar between the two groups (1.73 ± 0.67 vs 1.82 ± 0.48 mV, P = 0.488). Further, the total activation time of the RA was longer in the patients with a previous history of smoking than in those without a history of smoking, but not so for the LA. Furthermore, the voltage reduction in the RA was related to the smoking intensity-duration (Pearson's correlation, r = 0.650, P <0.001). Conclusions: In patients with atrial fibrillation, the RA mean voltage and total activation time were significantly correlated to smoking and had a dose-dependent effect.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalJournal of Cardiovascular Electrophysiology
Volume19
Issue number3
DOIs
Publication statusPublished - Mar 2008
Externally publishedYes

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Atrial Fibrillation
Smoking
Pulmonary Veins
Cardiovascular Diseases
History

Keywords

  • Atrial fibrillation
  • Pulmonary vein isolation
  • Smoking
  • Total activation time
  • Voltage

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Impairment of the atrial substrates by chronic cigarette smoking in patients with atrial fibrillation. / Tuan, Ta Chuan; Chang, Shih Lin; Tai, Ching Tai; Lin, Yenn Jiang; Hu, Yu Feng; Lo, Li Wei; Wongcharoen, Wanwarang; Udyavar, Ameya R.; Chiang, Shuo Ju; Chen, Yi Jen; Tsao, Hsuan Ming; Ueng, Kwo Chang; Chen, Shih Ann.

In: Journal of Cardiovascular Electrophysiology, Vol. 19, No. 3, 03.2008, p. 259-265.

Research output: Contribution to journalArticle

Tuan, TC, Chang, SL, Tai, CT, Lin, YJ, Hu, YF, Lo, LW, Wongcharoen, W, Udyavar, AR, Chiang, SJ, Chen, YJ, Tsao, HM, Ueng, KC & Chen, SA 2008, 'Impairment of the atrial substrates by chronic cigarette smoking in patients with atrial fibrillation', Journal of Cardiovascular Electrophysiology, vol. 19, no. 3, pp. 259-265. https://doi.org/10.1111/j.1540-8167.2007.01057.x
Tuan, Ta Chuan ; Chang, Shih Lin ; Tai, Ching Tai ; Lin, Yenn Jiang ; Hu, Yu Feng ; Lo, Li Wei ; Wongcharoen, Wanwarang ; Udyavar, Ameya R. ; Chiang, Shuo Ju ; Chen, Yi Jen ; Tsao, Hsuan Ming ; Ueng, Kwo Chang ; Chen, Shih Ann. / Impairment of the atrial substrates by chronic cigarette smoking in patients with atrial fibrillation. In: Journal of Cardiovascular Electrophysiology. 2008 ; Vol. 19, No. 3. pp. 259-265.
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abstract = "Smoking, Voltage, and Atrial Fibrillation. Background: Smoking is a major risk factor for cardiovascular disease. The impact of smoking on the right and left atrial substrates is unknown. Methods: This study included 88 patients (age 50 ± 13 years, M/F = 71/17) who underwent four pulmonary veins isolation (PVI) for paroxysmal atrial fibrillation (AF). The mean voltage and total activation time of the individual atria were obtained by using a NavX mapping system, and were compared between the patients with and without a previous smoking history. The dose effect was evaluated by the smoking intensity-duration, defined as the number of packs per day plus how many years they had been smoking. Results: The right atrial (RA) mean voltage was lower in the patients with a previous history of smoking than in those without a history of smoking (1.92 ± 0.49 vs 2.17 ± 0.56 mV, P <0.05). The left atrial (LA) mean voltage was similar between the two groups (1.73 ± 0.67 vs 1.82 ± 0.48 mV, P = 0.488). Further, the total activation time of the RA was longer in the patients with a previous history of smoking than in those without a history of smoking, but not so for the LA. Furthermore, the voltage reduction in the RA was related to the smoking intensity-duration (Pearson's correlation, r = 0.650, P <0.001). Conclusions: In patients with atrial fibrillation, the RA mean voltage and total activation time were significantly correlated to smoking and had a dose-dependent effect.",
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AU - Tuan, Ta Chuan

AU - Chang, Shih Lin

AU - Tai, Ching Tai

AU - Lin, Yenn Jiang

AU - Hu, Yu Feng

AU - Lo, Li Wei

AU - Wongcharoen, Wanwarang

AU - Udyavar, Ameya R.

AU - Chiang, Shuo Ju

AU - Chen, Yi Jen

AU - Tsao, Hsuan Ming

AU - Ueng, Kwo Chang

AU - Chen, Shih Ann

PY - 2008/3

Y1 - 2008/3

N2 - Smoking, Voltage, and Atrial Fibrillation. Background: Smoking is a major risk factor for cardiovascular disease. The impact of smoking on the right and left atrial substrates is unknown. Methods: This study included 88 patients (age 50 ± 13 years, M/F = 71/17) who underwent four pulmonary veins isolation (PVI) for paroxysmal atrial fibrillation (AF). The mean voltage and total activation time of the individual atria were obtained by using a NavX mapping system, and were compared between the patients with and without a previous smoking history. The dose effect was evaluated by the smoking intensity-duration, defined as the number of packs per day plus how many years they had been smoking. Results: The right atrial (RA) mean voltage was lower in the patients with a previous history of smoking than in those without a history of smoking (1.92 ± 0.49 vs 2.17 ± 0.56 mV, P <0.05). The left atrial (LA) mean voltage was similar between the two groups (1.73 ± 0.67 vs 1.82 ± 0.48 mV, P = 0.488). Further, the total activation time of the RA was longer in the patients with a previous history of smoking than in those without a history of smoking, but not so for the LA. Furthermore, the voltage reduction in the RA was related to the smoking intensity-duration (Pearson's correlation, r = 0.650, P <0.001). Conclusions: In patients with atrial fibrillation, the RA mean voltage and total activation time were significantly correlated to smoking and had a dose-dependent effect.

AB - Smoking, Voltage, and Atrial Fibrillation. Background: Smoking is a major risk factor for cardiovascular disease. The impact of smoking on the right and left atrial substrates is unknown. Methods: This study included 88 patients (age 50 ± 13 years, M/F = 71/17) who underwent four pulmonary veins isolation (PVI) for paroxysmal atrial fibrillation (AF). The mean voltage and total activation time of the individual atria were obtained by using a NavX mapping system, and were compared between the patients with and without a previous smoking history. The dose effect was evaluated by the smoking intensity-duration, defined as the number of packs per day plus how many years they had been smoking. Results: The right atrial (RA) mean voltage was lower in the patients with a previous history of smoking than in those without a history of smoking (1.92 ± 0.49 vs 2.17 ± 0.56 mV, P <0.05). The left atrial (LA) mean voltage was similar between the two groups (1.73 ± 0.67 vs 1.82 ± 0.48 mV, P = 0.488). Further, the total activation time of the RA was longer in the patients with a previous history of smoking than in those without a history of smoking, but not so for the LA. Furthermore, the voltage reduction in the RA was related to the smoking intensity-duration (Pearson's correlation, r = 0.650, P <0.001). Conclusions: In patients with atrial fibrillation, the RA mean voltage and total activation time were significantly correlated to smoking and had a dose-dependent effect.

KW - Atrial fibrillation

KW - Pulmonary vein isolation

KW - Smoking

KW - Total activation time

KW - Voltage

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