Impaired micturition reflex caused by acute selective dorsal or ventral root(s) rhizotomy in anesthetized rats

Jiuan Miaw Liao, Chen Li Cheng, Shin Da Lee, Gin Den Chen, Kuo Jung Chen, Chao Hsun Yang, Shwu Fen Pan, Mei Jung Chen, Pei Chen Huang, Tzer Bin Lin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To clarify the contributions of parasympathetic inputs and outputs to the micturition reflex. Materials and Methods: Intra-vesical pressure (IVP), external urethral sphincter electromyogram (EMG), pelvic afferent nerve activities (PANA), and pelvic efferent nerve activities (PENA) as well as the time-derived IVP (dIVP, an index of bladder contractility) were evaluated in intact and acute dorsal or ventral root(s) rhizotomized (DRX and VRX, respectively) rats. Results: In DRX rats, when compared with that in intact stage, the voiding frequency was decreased (75 ± 15% of intact, P <0.05, n = 8), while the threshold pressure to trigger voiding contractions was significantly increased (187 ± 75% of intact, P <0.05, n = 8). In addition, several insufficient contractions (5.3 ± 3.5 contractions/voiding, P <0.05, n = 8) occurred in ahead of each voiding contraction. On the other hand, in VRX rats, the peak and rebound IVP were significantly decreased (90 ± 3.5% and 75 ± 11.3% of intact, P <0.01, n = 8), while the threshold pressure was not affected (102 ± 11% of intact, P = NS, n = 8). The time-derived parameters were significantly decreased in VRX (peak dIVP, 78 ± 10.2%, rebound dIVP, 75 ± 15.6%, minimal dIVP, 68 ± 14% of intact, P <0.01, n = 8) but only peak dIVP was decreased (85 ± 11% of intact, P <0.01, n = 8) in DRX rats. Conclusion: Acute selective DRX and VRX rat can be an animal model to investigate peripheral neural control in micturition functions.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalNeurourology and Urodynamics
Volume25
Issue number3
DOIs
Publication statusPublished - 2006
Externally publishedYes

Fingerprint

Rhizotomy
Urination
Spinal Nerve Roots
Reflex
Urinary Bladder
Pressure
Electromyography
Urethra
Animal Models

Keywords

  • Cystometry
  • Electromyogram
  • Motor
  • Sensory
  • Spinal cord

ASJC Scopus subject areas

  • Clinical Neurology
  • Nephrology
  • Urology

Cite this

Impaired micturition reflex caused by acute selective dorsal or ventral root(s) rhizotomy in anesthetized rats. / Liao, Jiuan Miaw; Cheng, Chen Li; Lee, Shin Da; Chen, Gin Den; Chen, Kuo Jung; Yang, Chao Hsun; Pan, Shwu Fen; Chen, Mei Jung; Huang, Pei Chen; Lin, Tzer Bin.

In: Neurourology and Urodynamics, Vol. 25, No. 3, 2006, p. 283-289.

Research output: Contribution to journalArticle

Liao, JM, Cheng, CL, Lee, SD, Chen, GD, Chen, KJ, Yang, CH, Pan, SF, Chen, MJ, Huang, PC & Lin, TB 2006, 'Impaired micturition reflex caused by acute selective dorsal or ventral root(s) rhizotomy in anesthetized rats', Neurourology and Urodynamics, vol. 25, no. 3, pp. 283-289. https://doi.org/10.1002/nau.20220
Liao, Jiuan Miaw ; Cheng, Chen Li ; Lee, Shin Da ; Chen, Gin Den ; Chen, Kuo Jung ; Yang, Chao Hsun ; Pan, Shwu Fen ; Chen, Mei Jung ; Huang, Pei Chen ; Lin, Tzer Bin. / Impaired micturition reflex caused by acute selective dorsal or ventral root(s) rhizotomy in anesthetized rats. In: Neurourology and Urodynamics. 2006 ; Vol. 25, No. 3. pp. 283-289.
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abstract = "Purpose: To clarify the contributions of parasympathetic inputs and outputs to the micturition reflex. Materials and Methods: Intra-vesical pressure (IVP), external urethral sphincter electromyogram (EMG), pelvic afferent nerve activities (PANA), and pelvic efferent nerve activities (PENA) as well as the time-derived IVP (dIVP, an index of bladder contractility) were evaluated in intact and acute dorsal or ventral root(s) rhizotomized (DRX and VRX, respectively) rats. Results: In DRX rats, when compared with that in intact stage, the voiding frequency was decreased (75 ± 15{\%} of intact, P <0.05, n = 8), while the threshold pressure to trigger voiding contractions was significantly increased (187 ± 75{\%} of intact, P <0.05, n = 8). In addition, several insufficient contractions (5.3 ± 3.5 contractions/voiding, P <0.05, n = 8) occurred in ahead of each voiding contraction. On the other hand, in VRX rats, the peak and rebound IVP were significantly decreased (90 ± 3.5{\%} and 75 ± 11.3{\%} of intact, P <0.01, n = 8), while the threshold pressure was not affected (102 ± 11{\%} of intact, P = NS, n = 8). The time-derived parameters were significantly decreased in VRX (peak dIVP, 78 ± 10.2{\%}, rebound dIVP, 75 ± 15.6{\%}, minimal dIVP, 68 ± 14{\%} of intact, P <0.01, n = 8) but only peak dIVP was decreased (85 ± 11{\%} of intact, P <0.01, n = 8) in DRX rats. Conclusion: Acute selective DRX and VRX rat can be an animal model to investigate peripheral neural control in micturition functions.",
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T1 - Impaired micturition reflex caused by acute selective dorsal or ventral root(s) rhizotomy in anesthetized rats

AU - Liao, Jiuan Miaw

AU - Cheng, Chen Li

AU - Lee, Shin Da

AU - Chen, Gin Den

AU - Chen, Kuo Jung

AU - Yang, Chao Hsun

AU - Pan, Shwu Fen

AU - Chen, Mei Jung

AU - Huang, Pei Chen

AU - Lin, Tzer Bin

PY - 2006

Y1 - 2006

N2 - Purpose: To clarify the contributions of parasympathetic inputs and outputs to the micturition reflex. Materials and Methods: Intra-vesical pressure (IVP), external urethral sphincter electromyogram (EMG), pelvic afferent nerve activities (PANA), and pelvic efferent nerve activities (PENA) as well as the time-derived IVP (dIVP, an index of bladder contractility) were evaluated in intact and acute dorsal or ventral root(s) rhizotomized (DRX and VRX, respectively) rats. Results: In DRX rats, when compared with that in intact stage, the voiding frequency was decreased (75 ± 15% of intact, P <0.05, n = 8), while the threshold pressure to trigger voiding contractions was significantly increased (187 ± 75% of intact, P <0.05, n = 8). In addition, several insufficient contractions (5.3 ± 3.5 contractions/voiding, P <0.05, n = 8) occurred in ahead of each voiding contraction. On the other hand, in VRX rats, the peak and rebound IVP were significantly decreased (90 ± 3.5% and 75 ± 11.3% of intact, P <0.01, n = 8), while the threshold pressure was not affected (102 ± 11% of intact, P = NS, n = 8). The time-derived parameters were significantly decreased in VRX (peak dIVP, 78 ± 10.2%, rebound dIVP, 75 ± 15.6%, minimal dIVP, 68 ± 14% of intact, P <0.01, n = 8) but only peak dIVP was decreased (85 ± 11% of intact, P <0.01, n = 8) in DRX rats. Conclusion: Acute selective DRX and VRX rat can be an animal model to investigate peripheral neural control in micturition functions.

AB - Purpose: To clarify the contributions of parasympathetic inputs and outputs to the micturition reflex. Materials and Methods: Intra-vesical pressure (IVP), external urethral sphincter electromyogram (EMG), pelvic afferent nerve activities (PANA), and pelvic efferent nerve activities (PENA) as well as the time-derived IVP (dIVP, an index of bladder contractility) were evaluated in intact and acute dorsal or ventral root(s) rhizotomized (DRX and VRX, respectively) rats. Results: In DRX rats, when compared with that in intact stage, the voiding frequency was decreased (75 ± 15% of intact, P <0.05, n = 8), while the threshold pressure to trigger voiding contractions was significantly increased (187 ± 75% of intact, P <0.05, n = 8). In addition, several insufficient contractions (5.3 ± 3.5 contractions/voiding, P <0.05, n = 8) occurred in ahead of each voiding contraction. On the other hand, in VRX rats, the peak and rebound IVP were significantly decreased (90 ± 3.5% and 75 ± 11.3% of intact, P <0.01, n = 8), while the threshold pressure was not affected (102 ± 11% of intact, P = NS, n = 8). The time-derived parameters were significantly decreased in VRX (peak dIVP, 78 ± 10.2%, rebound dIVP, 75 ± 15.6%, minimal dIVP, 68 ± 14% of intact, P <0.01, n = 8) but only peak dIVP was decreased (85 ± 11% of intact, P <0.01, n = 8) in DRX rats. Conclusion: Acute selective DRX and VRX rat can be an animal model to investigate peripheral neural control in micturition functions.

KW - Cystometry

KW - Electromyogram

KW - Motor

KW - Sensory

KW - Spinal cord

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