Impacts of Female Gonadal Hormones on Pelvic Organ-related Neural Plasticity

Hsien Yu Peng, Tzer Bin Lin

Research output: Contribution to journalArticle

Abstract

Estrogen is a gonadal steroid with pronounced tropic effects on neurons throughout the peripheral and central nervous systems. Administration of estradiol (E2) was demonstrated to increase the efficacy of excitatory synapse, which is presumed to be crucial for the development of forms of plasticity. Although the underlying mechanism of how estrogen impacts on neural plasticity has not yet been clearly defined, studies on learning and memory have demonstrated that E2 can regulate the N-methyl-d-aspartate (NMDA)-dependent neural transmission, and thereby modulate the effectiveness of synapse. We studied the pelvic-urethra reflex (PUR) potentiation, an NMDA-dependent reflex plasticity that has been suggested to participate in the continence of the lower urinary tract. Results obtained from electrophysiological recordings demonstrated that when compared with a sham operation, ovariectomy statistically decreased the stimulation-induced PUR potentiation and the associated urethra contraction wave; this effect was partially reversed by estradiol replacement. Acute intrathecal E2 administration also facilitated PUR activity in a dose-dependent manner; however, this can be reversed by pretreatment with the estrogen receptor antagonist, ICI 182,780, and NMDAR NR2B subunit antagonist, Co-101244. Similar to the administration of E2, spinal injection with ER-alpha and ER-beta agonists both facilitated PUR potentiation, suggesting that the activation of membrane ER-alpha and ER-beta receptors also participates in the impact of estrogen on PUR plasticity. By contrast, daily progesterone administration was demonstrated to attenuate PUR potentiation in ovariectomized rats as compared with sham-operated rats. These changes could be blocked by finasteride, rather than RU486. The induction of PUR plasticity is attenuated after intrathecal treatment with allopregnanolone and 3-alpha,5-alpha-tetrahydrodeoxycorticosterone. All these results suggest that gonadal hormones could have an impact on the neural plasticity mediating urine continence.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Volume4
Issue number6
DOIs
Publication statusPublished - Dec 2012
Externally publishedYes

Fingerprint

Gonadal Hormones
Neuronal Plasticity
Urethra
Reflex
Estrogens
Aspartic Acid
Synapses
Estradiol
Pregnanolone
Finasteride
Spinal Injections
Peripheral Nervous System
Ovariectomy
Urinary Tract
Synaptic Transmission
Progesterone
Central Nervous System
Steroids
Learning
Urine

Keywords

  • Crosstalk
  • Micturition
  • Neural plasticity
  • Neurosteroids
  • Pelvic nerve-to-urethra reflex
  • Progesterone
  • Urine continence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Impacts of Female Gonadal Hormones on Pelvic Organ-related Neural Plasticity. / Peng, Hsien Yu; Lin, Tzer Bin.

In: Journal of Experimental and Clinical Medicine(Taiwan), Vol. 4, No. 6, 12.2012, p. 313-316.

Research output: Contribution to journalArticle

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