Impact of varying anatomic sites on advanced stage and survival of oral cancer: A 9-year prospective cohort of 27 717 cases

William Wang Yu Su, Chiu Wen Su, Dun Cheng Chang, Shu Lin Chuang, Sam Li Sheng Chen, Chen Yang Hsu, Amy Ming Fang Yen, Sherry Yueh Hsia Chiu, Jean Ching Yuan Fann, Yi Huah Lee, Ya Chung Jeng, Yi Chia Lee, Han Mo Chiu, Tony Hsiu Hsi Chen, Cheng Ping Wang, Mu Kuan Chen

Research output: Contribution to journalArticle

Abstract

Background: To elucidate the impact of varying anatomic sites on advanced stage of and death from oral cancer. Methods: A total of 27 717 oral cancers mainly from a population-based visual inspection program in Taiwan from 2004 to 2009 was followed until the end of 2012. Results: Using lip cancer as reference, the odds ratios (95% confidence interval [CI]) of advanced stage of cancer were 2.20 (1.92-2.51) for tongue, 2.60 (2.28-2.97) for buccal, 2.68 (2.20-3.28) for floor of mouth, 2.96 (2.52-3.47) for hard palate, 6.04 (5.17-7.05) for gingiva, and 10.83 (9.20-12.74) for oropharynx. The estimated hazard ratios (95% CI) for oral cancer death increased from 1.48 (1.31-1.67) in buccal, 1.61 (1.43-1.82) in tongue, 1.68 (1.41-1.99) in floor of mouth, 1.79 (1.57-2.05) in gingiva, 1.97 (1.71-2.26) in hard palate, and 2.15 (1.89-2.45) in oropharynx. Conclusion: Different anatomic sites had variations in advanced stage of and death from oral cancer and need vigilant surveillance.

Original languageEnglish
JournalHead and Neck
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Mouth Neoplasms
Hard Palate
Mouth Floor
Oropharynx
Cheek
Gingiva
Tongue
Lip Neoplasms
Confidence Intervals
Taiwan
Odds Ratio
Population
Neoplasms

Keywords

  • anatomic site
  • betel quid chewing
  • cigarette smoking
  • mortality
  • oral cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Impact of varying anatomic sites on advanced stage and survival of oral cancer : A 9-year prospective cohort of 27 717 cases. / Su, William Wang Yu; Su, Chiu Wen; Chang, Dun Cheng; Chuang, Shu Lin; Chen, Sam Li Sheng; Hsu, Chen Yang; Yen, Amy Ming Fang; Chiu, Sherry Yueh Hsia; Fann, Jean Ching Yuan; Lee, Yi Huah; Jeng, Ya Chung; Lee, Yi Chia; Chiu, Han Mo; Chen, Tony Hsiu Hsi; Wang, Cheng Ping; Chen, Mu Kuan.

In: Head and Neck, 01.01.2019.

Research output: Contribution to journalArticle

Su, WWY, Su, CW, Chang, DC, Chuang, SL, Chen, SLS, Hsu, CY, Yen, AMF, Chiu, SYH, Fann, JCY, Lee, YH, Jeng, YC, Lee, YC, Chiu, HM, Chen, THH, Wang, CP & Chen, MK 2019, 'Impact of varying anatomic sites on advanced stage and survival of oral cancer: A 9-year prospective cohort of 27 717 cases', Head and Neck. https://doi.org/10.1002/hed.25579
Su, William Wang Yu ; Su, Chiu Wen ; Chang, Dun Cheng ; Chuang, Shu Lin ; Chen, Sam Li Sheng ; Hsu, Chen Yang ; Yen, Amy Ming Fang ; Chiu, Sherry Yueh Hsia ; Fann, Jean Ching Yuan ; Lee, Yi Huah ; Jeng, Ya Chung ; Lee, Yi Chia ; Chiu, Han Mo ; Chen, Tony Hsiu Hsi ; Wang, Cheng Ping ; Chen, Mu Kuan. / Impact of varying anatomic sites on advanced stage and survival of oral cancer : A 9-year prospective cohort of 27 717 cases. In: Head and Neck. 2019.
@article{d8f1dd2e5acc4a14af7e096d87dd7379,
title = "Impact of varying anatomic sites on advanced stage and survival of oral cancer: A 9-year prospective cohort of 27 717 cases",
abstract = "Background: To elucidate the impact of varying anatomic sites on advanced stage of and death from oral cancer. Methods: A total of 27 717 oral cancers mainly from a population-based visual inspection program in Taiwan from 2004 to 2009 was followed until the end of 2012. Results: Using lip cancer as reference, the odds ratios (95{\%} confidence interval [CI]) of advanced stage of cancer were 2.20 (1.92-2.51) for tongue, 2.60 (2.28-2.97) for buccal, 2.68 (2.20-3.28) for floor of mouth, 2.96 (2.52-3.47) for hard palate, 6.04 (5.17-7.05) for gingiva, and 10.83 (9.20-12.74) for oropharynx. The estimated hazard ratios (95{\%} CI) for oral cancer death increased from 1.48 (1.31-1.67) in buccal, 1.61 (1.43-1.82) in tongue, 1.68 (1.41-1.99) in floor of mouth, 1.79 (1.57-2.05) in gingiva, 1.97 (1.71-2.26) in hard palate, and 2.15 (1.89-2.45) in oropharynx. Conclusion: Different anatomic sites had variations in advanced stage of and death from oral cancer and need vigilant surveillance.",
keywords = "anatomic site, betel quid chewing, cigarette smoking, mortality, oral cancer",
author = "Su, {William Wang Yu} and Su, {Chiu Wen} and Chang, {Dun Cheng} and Chuang, {Shu Lin} and Chen, {Sam Li Sheng} and Hsu, {Chen Yang} and Yen, {Amy Ming Fang} and Chiu, {Sherry Yueh Hsia} and Fann, {Jean Ching Yuan} and Lee, {Yi Huah} and Jeng, {Ya Chung} and Lee, {Yi Chia} and Chiu, {Han Mo} and Chen, {Tony Hsiu Hsi} and Wang, {Cheng Ping} and Chen, {Mu Kuan}",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/hed.25579",
language = "English",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Impact of varying anatomic sites on advanced stage and survival of oral cancer

T2 - A 9-year prospective cohort of 27 717 cases

AU - Su, William Wang Yu

AU - Su, Chiu Wen

AU - Chang, Dun Cheng

AU - Chuang, Shu Lin

AU - Chen, Sam Li Sheng

AU - Hsu, Chen Yang

AU - Yen, Amy Ming Fang

AU - Chiu, Sherry Yueh Hsia

AU - Fann, Jean Ching Yuan

AU - Lee, Yi Huah

AU - Jeng, Ya Chung

AU - Lee, Yi Chia

AU - Chiu, Han Mo

AU - Chen, Tony Hsiu Hsi

AU - Wang, Cheng Ping

AU - Chen, Mu Kuan

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: To elucidate the impact of varying anatomic sites on advanced stage of and death from oral cancer. Methods: A total of 27 717 oral cancers mainly from a population-based visual inspection program in Taiwan from 2004 to 2009 was followed until the end of 2012. Results: Using lip cancer as reference, the odds ratios (95% confidence interval [CI]) of advanced stage of cancer were 2.20 (1.92-2.51) for tongue, 2.60 (2.28-2.97) for buccal, 2.68 (2.20-3.28) for floor of mouth, 2.96 (2.52-3.47) for hard palate, 6.04 (5.17-7.05) for gingiva, and 10.83 (9.20-12.74) for oropharynx. The estimated hazard ratios (95% CI) for oral cancer death increased from 1.48 (1.31-1.67) in buccal, 1.61 (1.43-1.82) in tongue, 1.68 (1.41-1.99) in floor of mouth, 1.79 (1.57-2.05) in gingiva, 1.97 (1.71-2.26) in hard palate, and 2.15 (1.89-2.45) in oropharynx. Conclusion: Different anatomic sites had variations in advanced stage of and death from oral cancer and need vigilant surveillance.

AB - Background: To elucidate the impact of varying anatomic sites on advanced stage of and death from oral cancer. Methods: A total of 27 717 oral cancers mainly from a population-based visual inspection program in Taiwan from 2004 to 2009 was followed until the end of 2012. Results: Using lip cancer as reference, the odds ratios (95% confidence interval [CI]) of advanced stage of cancer were 2.20 (1.92-2.51) for tongue, 2.60 (2.28-2.97) for buccal, 2.68 (2.20-3.28) for floor of mouth, 2.96 (2.52-3.47) for hard palate, 6.04 (5.17-7.05) for gingiva, and 10.83 (9.20-12.74) for oropharynx. The estimated hazard ratios (95% CI) for oral cancer death increased from 1.48 (1.31-1.67) in buccal, 1.61 (1.43-1.82) in tongue, 1.68 (1.41-1.99) in floor of mouth, 1.79 (1.57-2.05) in gingiva, 1.97 (1.71-2.26) in hard palate, and 2.15 (1.89-2.45) in oropharynx. Conclusion: Different anatomic sites had variations in advanced stage of and death from oral cancer and need vigilant surveillance.

KW - anatomic site

KW - betel quid chewing

KW - cigarette smoking

KW - mortality

KW - oral cancer

UR - http://www.scopus.com/inward/record.url?scp=85060137972&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060137972&partnerID=8YFLogxK

U2 - 10.1002/hed.25579

DO - 10.1002/hed.25579

M3 - Article

AN - SCOPUS:85060137972

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

ER -