Impact of varying anatomic sites on advanced stage and survival of oral cancer: A 9-year prospective cohort of 27 717 cases

William Wang Yu Su, Chiu Wen Su, Dun Cheng Chang, Shu Lin Chuang, Sam Li Sheng Chen, Chen Yang Hsu, Amy Ming Fang Yen, Sherry Yueh Hsia Chiu, Jean Ching Yuan Fann, Yi Huah Lee, Ya Chung Jeng, Yi Chia Lee, Han Mo Chiu, Tony Hsiu Hsi Chen, Cheng Ping Wang, Mu Kuan Chen

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2 Citations (Scopus)

Abstract

Background: To elucidate the impact of varying anatomic sites on advanced stage of and death from oral cancer. Methods: A total of 27 717 oral cancers mainly from a population-based visual inspection program in Taiwan from 2004 to 2009 was followed until the end of 2012. Results: Using lip cancer as reference, the odds ratios (95% confidence interval [CI]) of advanced stage of cancer were 2.20 (1.92-2.51) for tongue, 2.60 (2.28-2.97) for buccal, 2.68 (2.20-3.28) for floor of mouth, 2.96 (2.52-3.47) for hard palate, 6.04 (5.17-7.05) for gingiva, and 10.83 (9.20-12.74) for oropharynx. The estimated hazard ratios (95% CI) for oral cancer death increased from 1.48 (1.31-1.67) in buccal, 1.61 (1.43-1.82) in tongue, 1.68 (1.41-1.99) in floor of mouth, 1.79 (1.57-2.05) in gingiva, 1.97 (1.71-2.26) in hard palate, and 2.15 (1.89-2.45) in oropharynx. Conclusion: Different anatomic sites had variations in advanced stage of and death from oral cancer and need vigilant surveillance.

Original languageEnglish
JournalHead and Neck
DOIs
Publication statusAccepted/In press - Jan 1 2019

Keywords

  • anatomic site
  • betel quid chewing
  • cigarette smoking
  • mortality
  • oral cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Su, W. W. Y., Su, C. W., Chang, D. C., Chuang, S. L., Chen, S. L. S., Hsu, C. Y., Yen, A. M. F., Chiu, S. Y. H., Fann, J. C. Y., Lee, Y. H., Jeng, Y. C., Lee, Y. C., Chiu, H. M., Chen, T. H. H., Wang, C. P., & Chen, M. K. (Accepted/In press). Impact of varying anatomic sites on advanced stage and survival of oral cancer: A 9-year prospective cohort of 27 717 cases. Head and Neck. https://doi.org/10.1002/hed.25579