Impact of traumatic brain injury on dopaminergic transmission

Yuan Hao Chen, Eagle Yi Kung Huang, Tung Tai Kuo, Jonathan Miller, Yung Hsiao Chiang, Barry J. Hoffer

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Brain trauma is often associated with severe morbidity and is a major public health concern. Even when injury is mild and no obvious anatomic disruption is seen, many individuals suffer disabling neuropsychological impairments such as memory loss, mood dysfunction, substance abuse, and adjustment disorder. These changes may be related to subtle disruption of neural circuits as well as functional changes at the neurotransmitter level. In particular, there is considerable evidence that dopamine (DA) physiology in the nigrostriatal and mesocorticolimbic pathways might be impaired after traumatic brain injury (TBI). Alterations in DA levels can lead to oxidative stress and cellular dysfunction, and DA plays an important role in central nervous system inflammation. Therapeutic targeting of DA pathways may offer benefits for both neuronal survival and functional outcome after TBI. The purpose of this review is to discuss the role of DA pathology in acute TBI and the potential impact of therapies that target these systems for the treatment of TBI.

Original languageEnglish
Pages (from-to)1156-1168
Number of pages13
JournalCell Transplantation
Volume26
Issue number7
DOIs
Publication statusPublished - 2017

Fingerprint

Dopamine
Brain
Adjustment Disorders
Oxidative stress
Physiology
Memory Disorders
Neurology
Public health
Pathology
Brain Injuries
Substance-Related Disorders
Neurotransmitter Agents
Oxidative Stress
Central Nervous System
Public Health
Traumatic Brain Injury
Inflammation
Morbidity
Data storage equipment
Networks (circuits)

Keywords

  • DA
  • Traumatic brain injury

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

Cite this

Chen, Y. H., Huang, E. Y. K., Kuo, T. T., Miller, J., Chiang, Y. H., & Hoffer, B. J. (2017). Impact of traumatic brain injury on dopaminergic transmission. Cell Transplantation, 26(7), 1156-1168. https://doi.org/10.1177/0963689717714105

Impact of traumatic brain injury on dopaminergic transmission. / Chen, Yuan Hao; Huang, Eagle Yi Kung; Kuo, Tung Tai; Miller, Jonathan; Chiang, Yung Hsiao; Hoffer, Barry J.

In: Cell Transplantation, Vol. 26, No. 7, 2017, p. 1156-1168.

Research output: Contribution to journalReview article

Chen, YH, Huang, EYK, Kuo, TT, Miller, J, Chiang, YH & Hoffer, BJ 2017, 'Impact of traumatic brain injury on dopaminergic transmission', Cell Transplantation, vol. 26, no. 7, pp. 1156-1168. https://doi.org/10.1177/0963689717714105
Chen, Yuan Hao ; Huang, Eagle Yi Kung ; Kuo, Tung Tai ; Miller, Jonathan ; Chiang, Yung Hsiao ; Hoffer, Barry J. / Impact of traumatic brain injury on dopaminergic transmission. In: Cell Transplantation. 2017 ; Vol. 26, No. 7. pp. 1156-1168.
@article{7028ecc149ca47e3a70fc9046b6d9ea5,
title = "Impact of traumatic brain injury on dopaminergic transmission",
abstract = "Brain trauma is often associated with severe morbidity and is a major public health concern. Even when injury is mild and no obvious anatomic disruption is seen, many individuals suffer disabling neuropsychological impairments such as memory loss, mood dysfunction, substance abuse, and adjustment disorder. These changes may be related to subtle disruption of neural circuits as well as functional changes at the neurotransmitter level. In particular, there is considerable evidence that dopamine (DA) physiology in the nigrostriatal and mesocorticolimbic pathways might be impaired after traumatic brain injury (TBI). Alterations in DA levels can lead to oxidative stress and cellular dysfunction, and DA plays an important role in central nervous system inflammation. Therapeutic targeting of DA pathways may offer benefits for both neuronal survival and functional outcome after TBI. The purpose of this review is to discuss the role of DA pathology in acute TBI and the potential impact of therapies that target these systems for the treatment of TBI.",
keywords = "DA, Traumatic brain injury",
author = "Chen, {Yuan Hao} and Huang, {Eagle Yi Kung} and Kuo, {Tung Tai} and Jonathan Miller and Chiang, {Yung Hsiao} and Hoffer, {Barry J.}",
year = "2017",
doi = "10.1177/0963689717714105",
language = "English",
volume = "26",
pages = "1156--1168",
journal = "Cell Transplantation",
issn = "0963-6897",
publisher = "Cognizant Communication Corporation",
number = "7",

}

TY - JOUR

T1 - Impact of traumatic brain injury on dopaminergic transmission

AU - Chen, Yuan Hao

AU - Huang, Eagle Yi Kung

AU - Kuo, Tung Tai

AU - Miller, Jonathan

AU - Chiang, Yung Hsiao

AU - Hoffer, Barry J.

PY - 2017

Y1 - 2017

N2 - Brain trauma is often associated with severe morbidity and is a major public health concern. Even when injury is mild and no obvious anatomic disruption is seen, many individuals suffer disabling neuropsychological impairments such as memory loss, mood dysfunction, substance abuse, and adjustment disorder. These changes may be related to subtle disruption of neural circuits as well as functional changes at the neurotransmitter level. In particular, there is considerable evidence that dopamine (DA) physiology in the nigrostriatal and mesocorticolimbic pathways might be impaired after traumatic brain injury (TBI). Alterations in DA levels can lead to oxidative stress and cellular dysfunction, and DA plays an important role in central nervous system inflammation. Therapeutic targeting of DA pathways may offer benefits for both neuronal survival and functional outcome after TBI. The purpose of this review is to discuss the role of DA pathology in acute TBI and the potential impact of therapies that target these systems for the treatment of TBI.

AB - Brain trauma is often associated with severe morbidity and is a major public health concern. Even when injury is mild and no obvious anatomic disruption is seen, many individuals suffer disabling neuropsychological impairments such as memory loss, mood dysfunction, substance abuse, and adjustment disorder. These changes may be related to subtle disruption of neural circuits as well as functional changes at the neurotransmitter level. In particular, there is considerable evidence that dopamine (DA) physiology in the nigrostriatal and mesocorticolimbic pathways might be impaired after traumatic brain injury (TBI). Alterations in DA levels can lead to oxidative stress and cellular dysfunction, and DA plays an important role in central nervous system inflammation. Therapeutic targeting of DA pathways may offer benefits for both neuronal survival and functional outcome after TBI. The purpose of this review is to discuss the role of DA pathology in acute TBI and the potential impact of therapies that target these systems for the treatment of TBI.

KW - DA

KW - Traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=85032024091&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032024091&partnerID=8YFLogxK

U2 - 10.1177/0963689717714105

DO - 10.1177/0963689717714105

M3 - Review article

VL - 26

SP - 1156

EP - 1168

JO - Cell Transplantation

JF - Cell Transplantation

SN - 0963-6897

IS - 7

ER -