Impact of surgery on local and systemic responses of cytokines and adhesion molecules

Ming Tsan Lin, Sung Ling Yeh, Ming Shiang Wu, Jaw Town Lin, Po Huang Lee, Koung Yi Liaw, King Jen Chang, Wei Jao Chen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background/Aims: Operation may result in various kinds of biological responses in patients who undergo surgery. Recent studies revealed cytokine network is greatly involved in the biological response to surgical stress, as sepsis. Extended surgical injuries may result in a deregulated hyperinflammatory response. However, cytokine and adhesion molecule dynamics of the local area and circulatory blood in perioperative period have not been well clarified. Methodology: 18 patients with colorectal cancer undergoing operation were recruited into the study. The patients were without major systemic disease and without postoperative complications. Serum samples were taken before operation (Preop) and on post-operation day 1 (POD1), day 3 (P0D3), and day 7 (P0D7). Samples from the drain tube (local) were taken on POD 1, 3, and 7. Interleukin-6 (IL-6) and adhesion molecules, including ICAM-1, P-selectin, E-selectin, and L-selectin, in serum and drain fluid were measured using ELISA. Results: Serum IL-6 was lowest at Preop, and elevated and peaked on POD1. IL-6 levels in serum were significantly lower than those in drain fluid on POD1, 3, and 7. Circulatory IL-6 after surgery is speculated to come mainly from the surgical traumatic area. Serum P-selectin elevated after the operation and peaked on PODl. P-selectin in drain fluid also peaked on PODl. P-selectin in serum was significantly higher than that in the drain fluid on POD1, 3, and 7. By contrast to IL-6, circulatory P-selectin may come from sources other than the local area. Serum ICAM-1 diminished from Preop to POD1, and to POD3. ICAM-1 in drain fluid elevated from POD1 to P0D3, and also from POD3 to POD7. ICAM-1 in drain fluid was significantly lower than that in serum on POD1 and 3. The operation resulted in a significant decrease in systemic soluble ICAM-1 levels, which may associate the patients wtih post-operative organ failure. Serum and drain fluid E-selectin and L-selectin dynamics exhibited a similar pattern to that of ICAM-1. Discussion: For the first time, we demonstrate that surgery induced distinguished dynamic differences between local and systemic cytokine and adhesion molecule response. Circulating IL-6 and P-selectin incresaed after surgery and peaked on POD1. By contrast, surgery diminished the circulating ICAM-1 and E-selectin. Modulation of cytokine and adhesion molecule responses in the perioperative period, for example with nutritional or anticytokine therapy, may have potential clinical importance.

Original languageEnglish
Pages (from-to)1341-1345
Number of pages5
JournalHepato-Gastroenterology
Volume56
Issue number94-95
Publication statusPublished - 2009

Fingerprint

Intercellular Adhesion Molecule-1
P-Selectin
Cytokines
Interleukin-6
Serum
E-Selectin
L-Selectin
Perioperative Period
Intraoperative Complications
Colorectal Neoplasms
Sepsis
Enzyme-Linked Immunosorbent Assay

Keywords

  • Adhesion molecules
  • Colorectal cancer
  • Cytokine
  • Surgery

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Lin, M. T., Yeh, S. L., Wu, M. S., Lin, J. T., Lee, P. H., Liaw, K. Y., ... Chen, W. J. (2009). Impact of surgery on local and systemic responses of cytokines and adhesion molecules. Hepato-Gastroenterology, 56(94-95), 1341-1345.

Impact of surgery on local and systemic responses of cytokines and adhesion molecules. / Lin, Ming Tsan; Yeh, Sung Ling; Wu, Ming Shiang; Lin, Jaw Town; Lee, Po Huang; Liaw, Koung Yi; Chang, King Jen; Chen, Wei Jao.

In: Hepato-Gastroenterology, Vol. 56, No. 94-95, 2009, p. 1341-1345.

Research output: Contribution to journalArticle

Lin, MT, Yeh, SL, Wu, MS, Lin, JT, Lee, PH, Liaw, KY, Chang, KJ & Chen, WJ 2009, 'Impact of surgery on local and systemic responses of cytokines and adhesion molecules', Hepato-Gastroenterology, vol. 56, no. 94-95, pp. 1341-1345.
Lin MT, Yeh SL, Wu MS, Lin JT, Lee PH, Liaw KY et al. Impact of surgery on local and systemic responses of cytokines and adhesion molecules. Hepato-Gastroenterology. 2009;56(94-95):1341-1345.
Lin, Ming Tsan ; Yeh, Sung Ling ; Wu, Ming Shiang ; Lin, Jaw Town ; Lee, Po Huang ; Liaw, Koung Yi ; Chang, King Jen ; Chen, Wei Jao. / Impact of surgery on local and systemic responses of cytokines and adhesion molecules. In: Hepato-Gastroenterology. 2009 ; Vol. 56, No. 94-95. pp. 1341-1345.
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abstract = "Background/Aims: Operation may result in various kinds of biological responses in patients who undergo surgery. Recent studies revealed cytokine network is greatly involved in the biological response to surgical stress, as sepsis. Extended surgical injuries may result in a deregulated hyperinflammatory response. However, cytokine and adhesion molecule dynamics of the local area and circulatory blood in perioperative period have not been well clarified. Methodology: 18 patients with colorectal cancer undergoing operation were recruited into the study. The patients were without major systemic disease and without postoperative complications. Serum samples were taken before operation (Preop) and on post-operation day 1 (POD1), day 3 (P0D3), and day 7 (P0D7). Samples from the drain tube (local) were taken on POD 1, 3, and 7. Interleukin-6 (IL-6) and adhesion molecules, including ICAM-1, P-selectin, E-selectin, and L-selectin, in serum and drain fluid were measured using ELISA. Results: Serum IL-6 was lowest at Preop, and elevated and peaked on POD1. IL-6 levels in serum were significantly lower than those in drain fluid on POD1, 3, and 7. Circulatory IL-6 after surgery is speculated to come mainly from the surgical traumatic area. Serum P-selectin elevated after the operation and peaked on PODl. P-selectin in drain fluid also peaked on PODl. P-selectin in serum was significantly higher than that in the drain fluid on POD1, 3, and 7. By contrast to IL-6, circulatory P-selectin may come from sources other than the local area. Serum ICAM-1 diminished from Preop to POD1, and to POD3. ICAM-1 in drain fluid elevated from POD1 to P0D3, and also from POD3 to POD7. ICAM-1 in drain fluid was significantly lower than that in serum on POD1 and 3. The operation resulted in a significant decrease in systemic soluble ICAM-1 levels, which may associate the patients wtih post-operative organ failure. Serum and drain fluid E-selectin and L-selectin dynamics exhibited a similar pattern to that of ICAM-1. Discussion: For the first time, we demonstrate that surgery induced distinguished dynamic differences between local and systemic cytokine and adhesion molecule response. Circulating IL-6 and P-selectin incresaed after surgery and peaked on POD1. By contrast, surgery diminished the circulating ICAM-1 and E-selectin. Modulation of cytokine and adhesion molecule responses in the perioperative period, for example with nutritional or anticytokine therapy, may have potential clinical importance.",
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AU - Lin, Ming Tsan

AU - Yeh, Sung Ling

AU - Wu, Ming Shiang

AU - Lin, Jaw Town

AU - Lee, Po Huang

AU - Liaw, Koung Yi

AU - Chang, King Jen

AU - Chen, Wei Jao

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N2 - Background/Aims: Operation may result in various kinds of biological responses in patients who undergo surgery. Recent studies revealed cytokine network is greatly involved in the biological response to surgical stress, as sepsis. Extended surgical injuries may result in a deregulated hyperinflammatory response. However, cytokine and adhesion molecule dynamics of the local area and circulatory blood in perioperative period have not been well clarified. Methodology: 18 patients with colorectal cancer undergoing operation were recruited into the study. The patients were without major systemic disease and without postoperative complications. Serum samples were taken before operation (Preop) and on post-operation day 1 (POD1), day 3 (P0D3), and day 7 (P0D7). Samples from the drain tube (local) were taken on POD 1, 3, and 7. Interleukin-6 (IL-6) and adhesion molecules, including ICAM-1, P-selectin, E-selectin, and L-selectin, in serum and drain fluid were measured using ELISA. Results: Serum IL-6 was lowest at Preop, and elevated and peaked on POD1. IL-6 levels in serum were significantly lower than those in drain fluid on POD1, 3, and 7. Circulatory IL-6 after surgery is speculated to come mainly from the surgical traumatic area. Serum P-selectin elevated after the operation and peaked on PODl. P-selectin in drain fluid also peaked on PODl. P-selectin in serum was significantly higher than that in the drain fluid on POD1, 3, and 7. By contrast to IL-6, circulatory P-selectin may come from sources other than the local area. Serum ICAM-1 diminished from Preop to POD1, and to POD3. ICAM-1 in drain fluid elevated from POD1 to P0D3, and also from POD3 to POD7. ICAM-1 in drain fluid was significantly lower than that in serum on POD1 and 3. The operation resulted in a significant decrease in systemic soluble ICAM-1 levels, which may associate the patients wtih post-operative organ failure. Serum and drain fluid E-selectin and L-selectin dynamics exhibited a similar pattern to that of ICAM-1. Discussion: For the first time, we demonstrate that surgery induced distinguished dynamic differences between local and systemic cytokine and adhesion molecule response. Circulating IL-6 and P-selectin incresaed after surgery and peaked on POD1. By contrast, surgery diminished the circulating ICAM-1 and E-selectin. Modulation of cytokine and adhesion molecule responses in the perioperative period, for example with nutritional or anticytokine therapy, may have potential clinical importance.

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