Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience)

Yi Wei Chen, Tai-Tong Wong, Donald Ming Tak Ho, Pin I. Huang, Kai Ping Chang, Cheng Ying Shiau, Sang Hue Yen

Research output: Contribution to journalReview article

89 Citations (Scopus)

Abstract

Purpose: To assess outcomes and prognostic factors in radiotherapy of pediatric central nervous system atypical teratoid/rhabdoid tumor (AT/RT). Methods and Materials: Seventeen patients with central nervous system AT/RT were retrospectively reviewed after curative radiotherapy as primary or adjuvant therapy between January 1990 and December 2003. Overall and failure-free survival rates were calculated using the Kaplan-Meier method. The log-rank method was used to compare the effects of dosage (>50 Gy or ≤50 Gy) and treatment duration (>45 days or ≤45 days). Multivariate analysis was performed for prognostic factors. Results: Median overall survival and failure-free survival were 17 and 11 months, respectively. The 3 longest-surviving patients were older, underwent gross tumor removal, and completed both craniospinal and focal boost irradiation. Multivariate analysis revealed a significant relationship between the following: overall survival and performance status (p = 0.019), failure-free survival and total irradiation dose (p = 0.037), time interval between surgery and radiotherapy initiation (p = 0.031), and time interval between surgery and radiotherapy end point (p = 0.047). Conclusion: Radiotherapy is crucial in the treatment of AT/RT. We recommend initiating radiotherapy immediately postoperatively and before systemic chemotherapy in pediatric patients ≥3 years of age.

Original languageEnglish
Pages (from-to)1038-1043
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume64
Issue number4
DOIs
Publication statusPublished - Mar 15 2006
Externally publishedYes

Keywords

  • Atypical teratoid/rhabdoid tumor
  • Brain neoplasm
  • Combined modality therapy
  • Craniospinal irradiation
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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