Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience)

Yi Wei Chen, Tai-Tong Wong, Donald Ming Tak Ho, Pin I. Huang, Kai Ping Chang, Cheng Ying Shiau, Sang Hue Yen

Research output: Contribution to journalReview article

83 Citations (Scopus)

Abstract

Purpose: To assess outcomes and prognostic factors in radiotherapy of pediatric central nervous system atypical teratoid/rhabdoid tumor (AT/RT). Methods and Materials: Seventeen patients with central nervous system AT/RT were retrospectively reviewed after curative radiotherapy as primary or adjuvant therapy between January 1990 and December 2003. Overall and failure-free survival rates were calculated using the Kaplan-Meier method. The log-rank method was used to compare the effects of dosage (>50 Gy or ≤50 Gy) and treatment duration (>45 days or ≤45 days). Multivariate analysis was performed for prognostic factors. Results: Median overall survival and failure-free survival were 17 and 11 months, respectively. The 3 longest-surviving patients were older, underwent gross tumor removal, and completed both craniospinal and focal boost irradiation. Multivariate analysis revealed a significant relationship between the following: overall survival and performance status (p = 0.019), failure-free survival and total irradiation dose (p = 0.037), time interval between surgery and radiotherapy initiation (p = 0.031), and time interval between surgery and radiotherapy end point (p = 0.047). Conclusion: Radiotherapy is crucial in the treatment of AT/RT. We recommend initiating radiotherapy immediately postoperatively and before systemic chemotherapy in pediatric patients ≥3 years of age.

Original languageEnglish
Pages (from-to)1038-1043
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume64
Issue number4
DOIs
Publication statusPublished - Mar 15 2006
Externally publishedYes

Fingerprint

radiation therapy
Radiotherapy
tumors
Pediatrics
central nervous system
Survival
surgery
Multivariate Analysis
Central Nervous System
intervals
dosage
irradiation
chemotherapy
acceleration (physics)
Atypical Teratoid Tumor
Typical Teratoid Rhabdoid Tumor
therapy
Therapeutics
Survival Rate
Drug Therapy

Keywords

  • Atypical teratoid/rhabdoid tumor
  • Brain neoplasm
  • Combined modality therapy
  • Craniospinal irradiation
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience). / Chen, Yi Wei; Wong, Tai-Tong; Ho, Donald Ming Tak; Huang, Pin I.; Chang, Kai Ping; Shiau, Cheng Ying; Yen, Sang Hue.

In: International Journal of Radiation Oncology Biology Physics, Vol. 64, No. 4, 15.03.2006, p. 1038-1043.

Research output: Contribution to journalReview article

Chen, Yi Wei ; Wong, Tai-Tong ; Ho, Donald Ming Tak ; Huang, Pin I. ; Chang, Kai Ping ; Shiau, Cheng Ying ; Yen, Sang Hue. / Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience). In: International Journal of Radiation Oncology Biology Physics. 2006 ; Vol. 64, No. 4. pp. 1038-1043.
@article{2ecc7a8bfa444826a0d2de426888c71f,
title = "Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience)",
abstract = "Purpose: To assess outcomes and prognostic factors in radiotherapy of pediatric central nervous system atypical teratoid/rhabdoid tumor (AT/RT). Methods and Materials: Seventeen patients with central nervous system AT/RT were retrospectively reviewed after curative radiotherapy as primary or adjuvant therapy between January 1990 and December 2003. Overall and failure-free survival rates were calculated using the Kaplan-Meier method. The log-rank method was used to compare the effects of dosage (>50 Gy or ≤50 Gy) and treatment duration (>45 days or ≤45 days). Multivariate analysis was performed for prognostic factors. Results: Median overall survival and failure-free survival were 17 and 11 months, respectively. The 3 longest-surviving patients were older, underwent gross tumor removal, and completed both craniospinal and focal boost irradiation. Multivariate analysis revealed a significant relationship between the following: overall survival and performance status (p = 0.019), failure-free survival and total irradiation dose (p = 0.037), time interval between surgery and radiotherapy initiation (p = 0.031), and time interval between surgery and radiotherapy end point (p = 0.047). Conclusion: Radiotherapy is crucial in the treatment of AT/RT. We recommend initiating radiotherapy immediately postoperatively and before systemic chemotherapy in pediatric patients ≥3 years of age.",
keywords = "Atypical teratoid/rhabdoid tumor, Brain neoplasm, Combined modality therapy, Craniospinal irradiation, Radiotherapy",
author = "Chen, {Yi Wei} and Tai-Tong Wong and Ho, {Donald Ming Tak} and Huang, {Pin I.} and Chang, {Kai Ping} and Shiau, {Cheng Ying} and Yen, {Sang Hue}",
year = "2006",
month = "3",
day = "15",
doi = "10.1016/j.ijrobp.2005.10.001",
language = "English",
volume = "64",
pages = "1038--1043",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience)

AU - Chen, Yi Wei

AU - Wong, Tai-Tong

AU - Ho, Donald Ming Tak

AU - Huang, Pin I.

AU - Chang, Kai Ping

AU - Shiau, Cheng Ying

AU - Yen, Sang Hue

PY - 2006/3/15

Y1 - 2006/3/15

N2 - Purpose: To assess outcomes and prognostic factors in radiotherapy of pediatric central nervous system atypical teratoid/rhabdoid tumor (AT/RT). Methods and Materials: Seventeen patients with central nervous system AT/RT were retrospectively reviewed after curative radiotherapy as primary or adjuvant therapy between January 1990 and December 2003. Overall and failure-free survival rates were calculated using the Kaplan-Meier method. The log-rank method was used to compare the effects of dosage (>50 Gy or ≤50 Gy) and treatment duration (>45 days or ≤45 days). Multivariate analysis was performed for prognostic factors. Results: Median overall survival and failure-free survival were 17 and 11 months, respectively. The 3 longest-surviving patients were older, underwent gross tumor removal, and completed both craniospinal and focal boost irradiation. Multivariate analysis revealed a significant relationship between the following: overall survival and performance status (p = 0.019), failure-free survival and total irradiation dose (p = 0.037), time interval between surgery and radiotherapy initiation (p = 0.031), and time interval between surgery and radiotherapy end point (p = 0.047). Conclusion: Radiotherapy is crucial in the treatment of AT/RT. We recommend initiating radiotherapy immediately postoperatively and before systemic chemotherapy in pediatric patients ≥3 years of age.

AB - Purpose: To assess outcomes and prognostic factors in radiotherapy of pediatric central nervous system atypical teratoid/rhabdoid tumor (AT/RT). Methods and Materials: Seventeen patients with central nervous system AT/RT were retrospectively reviewed after curative radiotherapy as primary or adjuvant therapy between January 1990 and December 2003. Overall and failure-free survival rates were calculated using the Kaplan-Meier method. The log-rank method was used to compare the effects of dosage (>50 Gy or ≤50 Gy) and treatment duration (>45 days or ≤45 days). Multivariate analysis was performed for prognostic factors. Results: Median overall survival and failure-free survival were 17 and 11 months, respectively. The 3 longest-surviving patients were older, underwent gross tumor removal, and completed both craniospinal and focal boost irradiation. Multivariate analysis revealed a significant relationship between the following: overall survival and performance status (p = 0.019), failure-free survival and total irradiation dose (p = 0.037), time interval between surgery and radiotherapy initiation (p = 0.031), and time interval between surgery and radiotherapy end point (p = 0.047). Conclusion: Radiotherapy is crucial in the treatment of AT/RT. We recommend initiating radiotherapy immediately postoperatively and before systemic chemotherapy in pediatric patients ≥3 years of age.

KW - Atypical teratoid/rhabdoid tumor

KW - Brain neoplasm

KW - Combined modality therapy

KW - Craniospinal irradiation

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=33644559052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644559052&partnerID=8YFLogxK

U2 - 10.1016/j.ijrobp.2005.10.001

DO - 10.1016/j.ijrobp.2005.10.001

M3 - Review article

C2 - 16406394

AN - SCOPUS:33644559052

VL - 64

SP - 1038

EP - 1043

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 4

ER -