Impact of metabolic syndrome on the incidence of chronic kidney disease: A Chinese cohort study

Tsan Yang, Chi Hong Chu, Chih Hsung Hsu, Po Chien Hsieh, Tieh Chi Chung, Chyi Huey Bai, San Lin You, Lee Ching Hwang, Chih Ming Lin, Chien An Sun

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Aim: Metabolic syndrome (MetS) is a major culprit in cardiovascular disease and chronic kidney disease (CKD) in Western populations. We studied the longitudinal association between MetS and incident CKD in Chinese adults. Methods: A cohort study was conducted in a nationally representative sample of 4248 Chinese adults in Taiwan. The MetS was defined according to a unified criteria set by several major organizations and CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m2. Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) adjusted for sex, age, body mass index (BMI) and serum levels of total cholesterol. Results: The prevalence of MetS among participants at baseline recruitment was 15.0% (637/4248). During a median follow-up period of 5.40 years, 208 subjects (4.9%) developed CKD. The multivariate-adjusted HR of CKD in participants with MetS compared with those without was 1.42 (95% CI = 1.03, 1.73). Additionally, there was a significantly graded relationship between the number of the MetS components and risk of CKD. Further, the relation between MetS and incident CKD was more robust in subjects with BMI >27.5 kg/m2 than in those with lower BMI. Conclusion: The results suggest that the presence of MetS was significantly associated with increased risk of incident CKD in a Chinese population. These findings warrant future studies to test the impact of preventing and treating MetS on the reduction of the occurrence of CKD. A longitudinal cohort study investigating the association between the metabolic syndrome and incident CKD in a Chinese population. The presence of the metabolic syndrome was associated with s significant risk of developing CKD (HR 1.42 95% CI 1.03-1.73).

Original languageEnglish
Pages (from-to)532-538
Number of pages7
Issue number6
Publication statusPublished - Aug 2012


  • Chinese
  • chronic kidney disease
  • cohort study
  • metabolic syndrome
  • obesity

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Impact of metabolic syndrome on the incidence of chronic kidney disease: A Chinese cohort study'. Together they form a unique fingerprint.

Cite this