Impact of Maspin polymorphism rs2289520 G/C and its interaction with gene to gene, alcohol consumption increase susceptibility to oral cancer occurrence

Po Yu Yang, Nae-Fang Miao, Chiao Wen Lin, Ying Erh Chou, Shun Fa Yang, Hui-Chuan Huang, Hsiu Ju Chang, Hsiu Ting Tsai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The purpose of this study was to identify gene polymorphisms of mammary serine protease inhibitor (Maspin) specific to patients with oral cancer susceptibility and clinicopathological status. Methodology/Principal Findings: Three single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR. The participants with G/G homozygotes or with G/C heterozygotes of Maspin rs2289520 polymorphism had a 2.07-fold (p = 0.01) and a 2.01-fold (p = 0.02) risk of developing oral cancer compared to those with C/C homozygotes. Moreover, gene-gene interaction increased the risk of oral cancer susceptibility among subjects expose to oral cancer related risk factors, including areca, alcohol, and tobacco consumption. Conclusion: G allele of Maspin rs2289520 polymorphism may be a factor that increases the susceptibility to oral cancer. The interactions of gene to oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.

Original languageEnglish
Article numbere0160841
JournalPLoS One
Volume11
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Serine Proteinase Inhibitors
Mouth Neoplasms
serine proteinases
proteinase inhibitors
Polymorphism
Alcohol Drinking
breasts
Breast
Genes
Alcohols
genetic polymorphism
genes
gene interaction
Areca
Homozygote
homozygosity
Tobacco
risk factors
Nucleotides
alcohol drinking

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Impact of Maspin polymorphism rs2289520 G/C and its interaction with gene to gene, alcohol consumption increase susceptibility to oral cancer occurrence. / Yang, Po Yu; Miao, Nae-Fang; Lin, Chiao Wen; Chou, Ying Erh; Yang, Shun Fa; Huang, Hui-Chuan; Chang, Hsiu Ju; Tsai, Hsiu Ting.

In: PLoS One, Vol. 11, No. 8, e0160841, 01.08.2016.

Research output: Contribution to journalArticle

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abstract = "Background: The purpose of this study was to identify gene polymorphisms of mammary serine protease inhibitor (Maspin) specific to patients with oral cancer susceptibility and clinicopathological status. Methodology/Principal Findings: Three single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR. The participants with G/G homozygotes or with G/C heterozygotes of Maspin rs2289520 polymorphism had a 2.07-fold (p = 0.01) and a 2.01-fold (p = 0.02) risk of developing oral cancer compared to those with C/C homozygotes. Moreover, gene-gene interaction increased the risk of oral cancer susceptibility among subjects expose to oral cancer related risk factors, including areca, alcohol, and tobacco consumption. Conclusion: G allele of Maspin rs2289520 polymorphism may be a factor that increases the susceptibility to oral cancer. The interactions of gene to oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.",
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AU - Chou, Ying Erh

AU - Yang, Shun Fa

AU - Huang, Hui-Chuan

AU - Chang, Hsiu Ju

AU - Tsai, Hsiu Ting

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