Impact of Maspin polymorphism rs2289520 G/C and its interaction with gene to gene, alcohol consumption increase susceptibility to oral cancer occurrence

Po Yu Yang, Nae-Fang Miao, Chiao Wen Lin, Ying Erh Chou, Shun Fa Yang, Hui-Chuan Huang, Hsiu Ju Chang, Hsiu Ting Tsai

Research output: Contribution to journalArticle

5 Citations (Scopus)


Background: The purpose of this study was to identify gene polymorphisms of mammary serine protease inhibitor (Maspin) specific to patients with oral cancer susceptibility and clinicopathological status. Methodology/Principal Findings: Three single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR. The participants with G/G homozygotes or with G/C heterozygotes of Maspin rs2289520 polymorphism had a 2.07-fold (p = 0.01) and a 2.01-fold (p = 0.02) risk of developing oral cancer compared to those with C/C homozygotes. Moreover, gene-gene interaction increased the risk of oral cancer susceptibility among subjects expose to oral cancer related risk factors, including areca, alcohol, and tobacco consumption. Conclusion: G allele of Maspin rs2289520 polymorphism may be a factor that increases the susceptibility to oral cancer. The interactions of gene to oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.

Original languageEnglish
Article numbere0160841
JournalPLoS One
Issue number8
Publication statusPublished - Aug 1 2016


ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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