Impact of location of epicardial adipose tissue, measured by coronary artery calcium-scoring computed tomography on obstructive coronary artery disease

Fu Zong Wu, Yi Luan Huang, Yen Chi Wang, Huey Shyan Lin, Chien Shung Chen, Yu Jen Ju, Kuan Rau Chiou, Chin Chang Cheng, Ming Ting Wu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Epicardial adipose tissue (EAT) is considered to play a role in the pathogenesis of coronary atherosclerosis. However, whether total EAT volume or location-specific EAT thickness may be a better predictor of obstructive coronary artery disease (CAD) is inconclusive. We investigated whether the total volume or location-specific thickness of EAT measured on computed tomography (CT) could be a useful marker of CAD on top of clinical risk factors and Agatston score. Two hundred eight consecutive subjects with clinical suspicion of CAD receiving coronary arterial calcium (CAC)-scoring CT and CT coronary angiography were retrospectively divided into 2 groups: an obstructive CAD group (n = 97) and a nonobstructive CAD group (n = 111). Total EAT volume and EAT thicknesses at different locations were measured on CAC-scoring CT. Left atrioventricular groove (AVG) EAT thickness was the sole EAT measurement that showed association with increasing number of vessels exhibiting ≥50% stenosis (p for trend <0.001). Logistic regression showed that left AVG EAT thickness was the most important EAT predictor of obstructive CAD (odds ratio 1.16, 95% confidence interval 1.04 to 1.29, p = 0.006; optimal threshold ≥15 mm, odds ratio 4.62, 95% confidence interval 2.24 to 9.56, p <0.001). Adding left AVG EAT thickness on top of clinical risk factors plus Agatston score improved prediction of obstructive CAD (area under the curve from 0.848 to 0.912, p = 0.002). In conclusion, excessive left AVG EAT adiposity is an important risk factor for obstructive CAD, independent of clinical risk factors and Agatston score. However, further trials are needed in investigation of combined assessment of location-specific EAT thickness and Agatston score on CAC scan as to whether this biomarker could improve CAD risk stratification in the general population.

Original languageEnglish
Pages (from-to)943-949
Number of pages7
JournalAmerican Journal of Cardiology
Volume112
Issue number7
DOIs
Publication statusPublished - Oct 1 2013
Externally publishedYes

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Adipose Tissue
Coronary Artery Disease
Coronary Vessels
Tomography
Calcium
Odds Ratio
Confidence Intervals
Adiposity
Coronary Angiography
Area Under Curve
Pathologic Constriction
Biomarkers
Logistic Models

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Impact of location of epicardial adipose tissue, measured by coronary artery calcium-scoring computed tomography on obstructive coronary artery disease. / Wu, Fu Zong; Huang, Yi Luan; Wang, Yen Chi; Lin, Huey Shyan; Chen, Chien Shung; Ju, Yu Jen; Chiou, Kuan Rau; Cheng, Chin Chang; Wu, Ming Ting.

In: American Journal of Cardiology, Vol. 112, No. 7, 01.10.2013, p. 943-949.

Research output: Contribution to journalArticle

Wu, Fu Zong ; Huang, Yi Luan ; Wang, Yen Chi ; Lin, Huey Shyan ; Chen, Chien Shung ; Ju, Yu Jen ; Chiou, Kuan Rau ; Cheng, Chin Chang ; Wu, Ming Ting. / Impact of location of epicardial adipose tissue, measured by coronary artery calcium-scoring computed tomography on obstructive coronary artery disease. In: American Journal of Cardiology. 2013 ; Vol. 112, No. 7. pp. 943-949.
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abstract = "Epicardial adipose tissue (EAT) is considered to play a role in the pathogenesis of coronary atherosclerosis. However, whether total EAT volume or location-specific EAT thickness may be a better predictor of obstructive coronary artery disease (CAD) is inconclusive. We investigated whether the total volume or location-specific thickness of EAT measured on computed tomography (CT) could be a useful marker of CAD on top of clinical risk factors and Agatston score. Two hundred eight consecutive subjects with clinical suspicion of CAD receiving coronary arterial calcium (CAC)-scoring CT and CT coronary angiography were retrospectively divided into 2 groups: an obstructive CAD group (n = 97) and a nonobstructive CAD group (n = 111). Total EAT volume and EAT thicknesses at different locations were measured on CAC-scoring CT. Left atrioventricular groove (AVG) EAT thickness was the sole EAT measurement that showed association with increasing number of vessels exhibiting ≥50{\%} stenosis (p for trend <0.001). Logistic regression showed that left AVG EAT thickness was the most important EAT predictor of obstructive CAD (odds ratio 1.16, 95{\%} confidence interval 1.04 to 1.29, p = 0.006; optimal threshold ≥15 mm, odds ratio 4.62, 95{\%} confidence interval 2.24 to 9.56, p <0.001). Adding left AVG EAT thickness on top of clinical risk factors plus Agatston score improved prediction of obstructive CAD (area under the curve from 0.848 to 0.912, p = 0.002). In conclusion, excessive left AVG EAT adiposity is an important risk factor for obstructive CAD, independent of clinical risk factors and Agatston score. However, further trials are needed in investigation of combined assessment of location-specific EAT thickness and Agatston score on CAC scan as to whether this biomarker could improve CAD risk stratification in the general population.",
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AU - Huang, Yi Luan

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AU - Lin, Huey Shyan

AU - Chen, Chien Shung

AU - Ju, Yu Jen

AU - Chiou, Kuan Rau

AU - Cheng, Chin Chang

AU - Wu, Ming Ting

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