Impact of circulating monocyte CD36 level on atrial fibrillation and subsequent catheter ablation

Yu Feng Hu, Hung I. Yeh, Hsuan Ming Tsao, Ching Tai Tai, Yenn Jiang Lin, Shih Lin Chang, Li Wei Lo, Ta Chuan Tuan, Cheng Hwai Tzeng, Sung Hao Huang, Yung Kuo Lin, Shih Ann Chen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Inflammation, an important mechanism in the pathogenesis of atrial fibrillation (AF), can be regulated by CD36 in monocytes. Objective: The purpose of this study was to test the hypothesis that CD36 in monocytes contributes to the pathogenesis of AF. Methods: A prospective study that enrolled 87 patients with AF and 70 without AF was conducted. Results: Compared to patients without AF, patients with AF had monocytes with a lower level of CD36 protein, which correlated with left atrial diameter, left atrial emptying fraction, and left atrial mean voltage. In AF patients after catheter ablation, Kaplan-Meier analysis showed that the sinus rhythm maintenance rate was higher in patients with high CD36 levels. Low CD36 level was an independent predictor of recurrence. After successful ablation, the CD36 level increased by 57%, reaching that of control patients. CD36 level was not correlated with the level of high-sensitivity C-reactive protein. Analysis of mRNA levels from a buffy coat revealed that AF patients had lower CD36 and interleukin-10 levels and higher peroxisome proliferator-activated receptor-γ and tumor necrosis factor-α levels, with CD36 level positively correlated with interleukin-10 level but inversely correlated with peroxisome proliferator-activated receptor-γ and tumor necrosis factor-α levels. Conclusion: Low CD36 levels in circulating monocytes were associated with AF occurrence and predicted recurrence after catheter ablation. The link between CD36 and AF identified a novel AF-related inflammatory pathway.

Original languageEnglish
Pages (from-to)650-656
Number of pages7
JournalHeart Rhythm
Volume8
Issue number5
DOIs
Publication statusPublished - May 2011

Fingerprint

Catheter Ablation
Atrial Fibrillation
Monocytes
Peroxisome Proliferator-Activated Receptors
Interleukin-10
Tumor Necrosis Factor-alpha
CD36 Antigens
Recurrence
Kaplan-Meier Estimate
C-Reactive Protein
Maintenance
Prospective Studies
Inflammation

Keywords

  • Atrial fibrillation
  • CD36
  • Inflammation
  • Mechanoelectrical function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Hu, Y. F., Yeh, H. I., Tsao, H. M., Tai, C. T., Lin, Y. J., Chang, S. L., ... Chen, S. A. (2011). Impact of circulating monocyte CD36 level on atrial fibrillation and subsequent catheter ablation. Heart Rhythm, 8(5), 650-656. https://doi.org/10.1016/j.hrthm.2010.12.036

Impact of circulating monocyte CD36 level on atrial fibrillation and subsequent catheter ablation. / Hu, Yu Feng; Yeh, Hung I.; Tsao, Hsuan Ming; Tai, Ching Tai; Lin, Yenn Jiang; Chang, Shih Lin; Lo, Li Wei; Tuan, Ta Chuan; Tzeng, Cheng Hwai; Huang, Sung Hao; Lin, Yung Kuo; Chen, Shih Ann.

In: Heart Rhythm, Vol. 8, No. 5, 05.2011, p. 650-656.

Research output: Contribution to journalArticle

Hu, YF, Yeh, HI, Tsao, HM, Tai, CT, Lin, YJ, Chang, SL, Lo, LW, Tuan, TC, Tzeng, CH, Huang, SH, Lin, YK & Chen, SA 2011, 'Impact of circulating monocyte CD36 level on atrial fibrillation and subsequent catheter ablation', Heart Rhythm, vol. 8, no. 5, pp. 650-656. https://doi.org/10.1016/j.hrthm.2010.12.036
Hu, Yu Feng ; Yeh, Hung I. ; Tsao, Hsuan Ming ; Tai, Ching Tai ; Lin, Yenn Jiang ; Chang, Shih Lin ; Lo, Li Wei ; Tuan, Ta Chuan ; Tzeng, Cheng Hwai ; Huang, Sung Hao ; Lin, Yung Kuo ; Chen, Shih Ann. / Impact of circulating monocyte CD36 level on atrial fibrillation and subsequent catheter ablation. In: Heart Rhythm. 2011 ; Vol. 8, No. 5. pp. 650-656.
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AU - Chang, Shih Lin

AU - Lo, Li Wei

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N2 - Background: Inflammation, an important mechanism in the pathogenesis of atrial fibrillation (AF), can be regulated by CD36 in monocytes. Objective: The purpose of this study was to test the hypothesis that CD36 in monocytes contributes to the pathogenesis of AF. Methods: A prospective study that enrolled 87 patients with AF and 70 without AF was conducted. Results: Compared to patients without AF, patients with AF had monocytes with a lower level of CD36 protein, which correlated with left atrial diameter, left atrial emptying fraction, and left atrial mean voltage. In AF patients after catheter ablation, Kaplan-Meier analysis showed that the sinus rhythm maintenance rate was higher in patients with high CD36 levels. Low CD36 level was an independent predictor of recurrence. After successful ablation, the CD36 level increased by 57%, reaching that of control patients. CD36 level was not correlated with the level of high-sensitivity C-reactive protein. Analysis of mRNA levels from a buffy coat revealed that AF patients had lower CD36 and interleukin-10 levels and higher peroxisome proliferator-activated receptor-γ and tumor necrosis factor-α levels, with CD36 level positively correlated with interleukin-10 level but inversely correlated with peroxisome proliferator-activated receptor-γ and tumor necrosis factor-α levels. Conclusion: Low CD36 levels in circulating monocytes were associated with AF occurrence and predicted recurrence after catheter ablation. The link between CD36 and AF identified a novel AF-related inflammatory pathway.

AB - Background: Inflammation, an important mechanism in the pathogenesis of atrial fibrillation (AF), can be regulated by CD36 in monocytes. Objective: The purpose of this study was to test the hypothesis that CD36 in monocytes contributes to the pathogenesis of AF. Methods: A prospective study that enrolled 87 patients with AF and 70 without AF was conducted. Results: Compared to patients without AF, patients with AF had monocytes with a lower level of CD36 protein, which correlated with left atrial diameter, left atrial emptying fraction, and left atrial mean voltage. In AF patients after catheter ablation, Kaplan-Meier analysis showed that the sinus rhythm maintenance rate was higher in patients with high CD36 levels. Low CD36 level was an independent predictor of recurrence. After successful ablation, the CD36 level increased by 57%, reaching that of control patients. CD36 level was not correlated with the level of high-sensitivity C-reactive protein. Analysis of mRNA levels from a buffy coat revealed that AF patients had lower CD36 and interleukin-10 levels and higher peroxisome proliferator-activated receptor-γ and tumor necrosis factor-α levels, with CD36 level positively correlated with interleukin-10 level but inversely correlated with peroxisome proliferator-activated receptor-γ and tumor necrosis factor-α levels. Conclusion: Low CD36 levels in circulating monocytes were associated with AF occurrence and predicted recurrence after catheter ablation. The link between CD36 and AF identified a novel AF-related inflammatory pathway.

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