Impact of chronic rhinosinusitis on severe asthma patients

Ta Jen Lee, Chia Hsiang Fu, Chun Hua Wang, Chi Che Huang, Chien Chia Huang, Po Hung Chang, Yi Wei Chen, Chia Chen Wu, Ching Lung Wu, Han Pin Kuo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Coexistence of chronic rhinosinusitis (CRS) with asthma appears to impair asthma control. Type-2 innate lymphoid cells (ILC2s) respond to the cytokines of thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33, thus contributing to airway diseases such as CRS and asthma. We investigate whether the augmented Th2-cytokines in CRS might be related to sinonasal tract ILC2s corresponding to enhanced IL-25, IL-33 and TSLP release in severe asthmatics, and be involved in asthma control. Twenty-eight asthmatics (12 nonsevere and 16 severe) with CRS receiving nasal surgery were enrolled. The predicted FEV1inversely associated with CRS severity of CT or endoscopy scores. Higher expression of Th2-driven cytokines (IL-4, IL-5, IL-9, and IL-13), TSLP, IL-25 and IL-33 in nasal tissues was observed in severe asthma. Severe asthmatics had higher ILC2 cell counts in their nasal tissues. ILC2 counts were positively correlated with Th2-cytokines. Nasal surgery significantly improved asthma control and lung function decline in severe asthma and CRS. The higher expression of IL-33/ILC2 axis-directed type 2 immune responses in nasal tissue of CRS brought the greater decline of lung function in severe asthma. ILC2-induced the upregulated activity of Th2-related cytokines in asthmatics with CRS may contribute to a recalcitrant status of asthma control.

Original languageEnglish
Article numbere0171047
JournalPLoS One
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 1 2017
Externally publishedYes

Fingerprint

asthma
Asthma
Interleukin-17
Cytokines
interleukins
cytokines
Tissue
Surgery
Nose
Nasal Surgical Procedures
Interleukin-9
lung function
Endoscopy
Interleukin-13
Interleukin-5
Interleukin-4
interleukin-9
surgery
interleukin-5
Lung

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lee, T. J., Fu, C. H., Wang, C. H., Huang, C. C., Huang, C. C., Chang, P. H., ... Kuo, H. P. (2017). Impact of chronic rhinosinusitis on severe asthma patients. PLoS One, 12(2), [e0171047]. https://doi.org/10.1371/journal.pone.0171047

Impact of chronic rhinosinusitis on severe asthma patients. / Lee, Ta Jen; Fu, Chia Hsiang; Wang, Chun Hua; Huang, Chi Che; Huang, Chien Chia; Chang, Po Hung; Chen, Yi Wei; Wu, Chia Chen; Wu, Ching Lung; Kuo, Han Pin.

In: PLoS One, Vol. 12, No. 2, e0171047, 01.02.2017.

Research output: Contribution to journalArticle

Lee, TJ, Fu, CH, Wang, CH, Huang, CC, Huang, CC, Chang, PH, Chen, YW, Wu, CC, Wu, CL & Kuo, HP 2017, 'Impact of chronic rhinosinusitis on severe asthma patients', PLoS One, vol. 12, no. 2, e0171047. https://doi.org/10.1371/journal.pone.0171047
Lee TJ, Fu CH, Wang CH, Huang CC, Huang CC, Chang PH et al. Impact of chronic rhinosinusitis on severe asthma patients. PLoS One. 2017 Feb 1;12(2). e0171047. https://doi.org/10.1371/journal.pone.0171047
Lee, Ta Jen ; Fu, Chia Hsiang ; Wang, Chun Hua ; Huang, Chi Che ; Huang, Chien Chia ; Chang, Po Hung ; Chen, Yi Wei ; Wu, Chia Chen ; Wu, Ching Lung ; Kuo, Han Pin. / Impact of chronic rhinosinusitis on severe asthma patients. In: PLoS One. 2017 ; Vol. 12, No. 2.
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