Impact of chronic obstruction pulmonary disease on survival in patients with advanced stage lung squamous cell carcinoma undergoing concurrent chemoradiotherapy

Kuo Chin Chiu, Wei Chun Lin, Chia Lun Chang, Szu Yuan Wu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: To date, no data are available regarding the effect of chronic obstruction pulmonary disease (COPD) and COPD with acute exacerbation (COPDAE) on survival in patients with lung squamous cell carcinoma (SCC) receiving definitive concurrent chemoradiotherapy (CCRT). Patients and methods: We enrolled 3986 patients with clinical stage IIIA–IIIB, unresectable lung SCC, who had received standard definitive CCRT, and categorized them into two groups based on their COPD status to compare overall survival outcomes. We also examined the effects of COPD severity (0, 1, or ≥2 hospitalizations for COPDA within 1 year before CCRT). Results: In the inverse probability of treatment weighting (IPTW)-adjusted model, the adjusted hazard ratio (aHR) (95% confidence interval (CI)) of all-cause death for COPD was 1.04 (1.01, 1.16), compared no COPD in patients with stage IIIA–IIIB lung SCC receiving definitive CCRT. In the IPTW-adjusted model, the aHRs (95% CIs) of 1 and ≥ 2 hospitalizations for COPDAE within 1 year before CCRT were 1.32 (1.19, 1.46) and 1.81 (1.49, 2.19) respectively, compared with no hospitalization for COPDAE. Con-clusion: COPD and its severity are significant independent risk factors for all-cause death in patients with stage IIIA–IIIB lung SCC receiving definitive CCRT. Hospitalization for COPDAE within 1 year before CCRT is the significant independent risk factor for lung cancer death in the patients with stage IIIA–IIIB lung SCC receiving definitive CCRT.

Original languageEnglish
Article number3231
JournalCancers
Volume13
Issue number13
DOIs
Publication statusPublished - Jul 1 2021

Keywords

  • Chronic obstruction pulmonary disease
  • Concurrent chemoradiotherapy
  • Lung cancer
  • Squamous cell carcinoma
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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