Impact of bowel preparation with low-volume (2-Liter) and intermediate-volume (3-Liter) polyethylene glycol on colonoscopy quality: A prospective observational study

Chi Liang Cheng, Yen Lin Kuo, Nai Jen Liu, Cheng Hui Lin, Jui Hsiang Tang, Yi Ning Tsui, Bai Ping Lee, Ming Yao Su, Cheng Tang Chiu

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Background/Aims: Two-liter polyethylene glycol (PEG) is the most commonly used bowel-cleansing regimen in Taiwan, but its efficacy is unsatisfactory. The aim of this study was to compare 2-liter and 3-liter PEG in terms of their impact on colonoscopy quality among an average-risk population. Methods: Two-liter PEG was provided between August 2012 and May 2013, while 3-liter PEG was provided between June 2013 and March 2014. A split-dose regimen was provided for morning colonoscopy and a same-day regimen was provided for afternoon colonoscopy. The level of bowel cleansing was prospectively scored. Results: A total of 407 consecutive subjects completed the 2-liter regimen, and another 407 consecutive subjects completed the 3-liter regimen. The 3-liter group had a significantly higher rate of excellent or good preparations, equivalent to a Boston bowel preparation scale of ≥7, than the 2-liter group (90 vs. 73%, p < 0.0001). More subjects in the 3-liter preparation group compared with the 2-liter group had overall adenoma (70 vs. 54%, p < 0.0001), proximal adenoma (47 vs. 35%, p = 0.0006), sessile serrated adenoma (28 vs. 6%, p < 0.0001), and advanced adenoma (21 vs. 9%, p < 0.0001). Conclusions: Three-liter PEG provided better cleansing quality and higher adenoma detection rate than 2-liter PEG.

Original languageEnglish
Pages (from-to)156-164
Number of pages9
JournalDigestion
Volume92
Issue number3
DOIs
Publication statusPublished - Oct 8 2015
Externally publishedYes

Keywords

  • Adenoma detection rate
  • Boston bowel preparation scale
  • Bowel cleansing
  • Bowel preparation
  • Colonoscopy
  • Polyethylene glycol
  • Sessile serrated adenoma

ASJC Scopus subject areas

  • Gastroenterology

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