Immunosuppressive roles of galectin-1 in the tumor microenvironment

Yanyu Huang, Hsiao Chi Wang, Junwei Zhao, Ming Heng Wu, Tsung Chieh Shih

Research output: Contribution to journalReview articlepeer-review

Abstract

Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immune suppressive mediators by tumor cells is one of the major mechanisms of tumor immune escape. Galectin-1 (Gal-1), a pivotal immunosuppressive molecule, is expressed by many types of cancer. Tumor-secreted Gal-1 can bind to glycosylated receptors on immune cells and trigger the suppression of immune cell function in the tumor microenvironment, contributing to the immune evasion of tumors. The aim of this review is to summarize the current literature on the expression and function of Gal-1 in the human tumor microenvironment, as well as therapeutics targeting Gal-1.

Original languageEnglish
Article number1398
JournalBiomolecules
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Galectin-1
  • Immunotherapy
  • LLS30
  • Microenvironment

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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