Immunopathology of hepatitis B virus infection

Hsiu Ting Tsai, Tzu Hsin Tsai, Tsong Ming Lu, Chi Chiang Yang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated with recovery from active diseases and is clinically used as a benchmark to assess response to treatment. Our studies have revealed that the anti-HBV immunoglobulins secreted are different in subclass patterns in different HBV infection status populations. These revelations may help to understand HBV escape and persistent infection and to develop strategies for prevention and therapeutic management of HBV infection.

Original languageEnglish
Pages (from-to)427-446
Number of pages20
JournalInternational Reviews of Immunology
Volume27
Issue number6
DOIs
Publication statusPublished - Nov 2008
Externally publishedYes

Fingerprint

Virus Diseases
Hepatitis B virus
Anti-Idiotypic Antibodies
Benchmarking
Adaptive Immunity
Innate Immunity
Immunoglobulins
Infection
Population

Keywords

  • Cellular immunity
  • Hepatitis B virus
  • Humoral immunity
  • IgG subclass
  • Immunopathology
  • Regulatory T cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Immunopathology of hepatitis B virus infection. / Tsai, Hsiu Ting; Tsai, Tzu Hsin; Lu, Tsong Ming; Yang, Chi Chiang.

In: International Reviews of Immunology, Vol. 27, No. 6, 11.2008, p. 427-446.

Research output: Contribution to journalArticle

Tsai, Hsiu Ting ; Tsai, Tzu Hsin ; Lu, Tsong Ming ; Yang, Chi Chiang. / Immunopathology of hepatitis B virus infection. In: International Reviews of Immunology. 2008 ; Vol. 27, No. 6. pp. 427-446.
@article{37416be19a314491af7368edd023b2d0,
title = "Immunopathology of hepatitis B virus infection",
abstract = "The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated with recovery from active diseases and is clinically used as a benchmark to assess response to treatment. Our studies have revealed that the anti-HBV immunoglobulins secreted are different in subclass patterns in different HBV infection status populations. These revelations may help to understand HBV escape and persistent infection and to develop strategies for prevention and therapeutic management of HBV infection.",
keywords = "Cellular immunity, Hepatitis B virus, Humoral immunity, IgG subclass, Immunopathology, Regulatory T cell",
author = "Tsai, {Hsiu Ting} and Tsai, {Tzu Hsin} and Lu, {Tsong Ming} and Yang, {Chi Chiang}",
year = "2008",
month = "11",
doi = "10.1080/08830180802295757",
language = "English",
volume = "27",
pages = "427--446",
journal = "International Reviews of Immunology",
issn = "0883-0185",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Immunopathology of hepatitis B virus infection

AU - Tsai, Hsiu Ting

AU - Tsai, Tzu Hsin

AU - Lu, Tsong Ming

AU - Yang, Chi Chiang

PY - 2008/11

Y1 - 2008/11

N2 - The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated with recovery from active diseases and is clinically used as a benchmark to assess response to treatment. Our studies have revealed that the anti-HBV immunoglobulins secreted are different in subclass patterns in different HBV infection status populations. These revelations may help to understand HBV escape and persistent infection and to develop strategies for prevention and therapeutic management of HBV infection.

AB - The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with persistent HBV infection. The presence of anti-HBe antibodies is often associated with recovery from active diseases and is clinically used as a benchmark to assess response to treatment. Our studies have revealed that the anti-HBV immunoglobulins secreted are different in subclass patterns in different HBV infection status populations. These revelations may help to understand HBV escape and persistent infection and to develop strategies for prevention and therapeutic management of HBV infection.

KW - Cellular immunity

KW - Hepatitis B virus

KW - Humoral immunity

KW - IgG subclass

KW - Immunopathology

KW - Regulatory T cell

UR - http://www.scopus.com/inward/record.url?scp=57449093624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57449093624&partnerID=8YFLogxK

U2 - 10.1080/08830180802295757

DO - 10.1080/08830180802295757

M3 - Article

C2 - 19065350

AN - SCOPUS:57449093624

VL - 27

SP - 427

EP - 446

JO - International Reviews of Immunology

JF - International Reviews of Immunology

SN - 0883-0185

IS - 6

ER -