Immune response to respiratory syncytial virus: Prevention of syncytia formation by human serum during in Vitro infection

H. Faden, Tzou-Yien Lin, J. J. Hong, P. L. Ogra

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Abstract

Human serum specimens containing respiratory syncytial virus (RSV)–specific neutralizing antibody were found to prevent the formation of syncytia when applied to HEp–2 tissue culture monolayers which had been infected with RSV 12 h previously. This was evidenced by the demonstration of RSV–infected cells without any syncytia formation in the monolayers treated with RSV antibody–positive serum. On the other hand, widespread syncytia formation was observed with antibody–negative control serum. The inhibitory effects of RSV antibody progressively declined when applied beyond 12 h after infection. Protection of the monolayer against syncytia formation occurred only in the presence of antibody and was quickly lost after the serum was removed. The titer of antisyncytial antibody correlated with the titer of neurtralization antibody.

Original languageEnglish
Pages (from-to)987-991
Number of pages5
JournalPediatric Research
Volume18
Issue number10
DOIs
Publication statusPublished - Jan 1 1984

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Respiratory Syncytial Viruses
Giant Cells
Antibodies
Infection
Serum
Neutralizing Antibodies
In Vitro Techniques

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Immune response to respiratory syncytial virus : Prevention of syncytia formation by human serum during in Vitro infection. / Faden, H.; Lin, Tzou-Yien; Hong, J. J.; Ogra, P. L.

In: Pediatric Research, Vol. 18, No. 10, 01.01.1984, p. 987-991.

Research output: Contribution to journalArticle

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