Immune response of single dose vaccination against 2009 pandemic influenza A (H1N1) in the Taiwanese elderly

Tsui Mai Kao, Szu Min Hsieh, Hsiang Chi Kung, Yi Chien Lee, Kuo Chin Huang, Li Min Huang, Feng Yee Chang, Ning Chi Wang, Yung Ching Liu, Wen Sen Lee, Hsingjin Eugene Liu, Chin I. Chen, Chien Hui Chen

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

We conducted a multi-center, randomized and laboratory-blinded clinical trial with subgroup analyses, involving adults aged greater than 60 years old (range 61-86 years old), to investigate the immunogenicity and the potential factors affecting the immune response of a monovalent, unadjuvanted, inactivated, split-virus vaccine. A total of 107 subjects were randomized to receive 15 and 30μg of hemagglutinin antigen in a 1:1 ratio. The immunogenicity was detected through hemagglutination inhibition (HAI) test of serum obtained before and 3 weeks after vaccination. By 3 weeks after vaccination, HAI titer ≥1:40 was observed in 75.5% and 81.1% of participants receiving 15 and 30μg of hemagglutinin antigen, respectively. Positive seroconversion was observed in 71.7% and 81.1% of recipients of the 15 and the 30μg, respectively. The GMTs increased by a factor of 10.7 and 17.4 in the groups of 15 and 30μg, respectively. This study indicated that one dose of 15μg hemagglutinin antigen without adjuvant induced protective immune response in the majority of elderly. Multivariate logistic regression analyses showed that gender, age and diabetes were statistically significant factors affecting the seroprotection rate (p=0.04, 0.01 and 0.01, respectively) and seroconversion rate (p=0.01, 0.01 and 0.01, respectively).

Original languageEnglish
Pages (from-to)6159-6163
Number of pages5
JournalVaccine
Volume28
Issue number38
DOIs
Publication statusPublished - Aug 2010

Keywords

  • 2009 Pandemic influenza A (H1N1)
  • Immune response
  • Vaccination

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

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