Imbalance between Left and Right Dorsolateral Prefrontal Cortex in Major Depression Is Linked to Negative Emotional Judgment: An fMRI Study in Severe Major Depressive Disorder

Simone Grimm, Johannes Beck, Daniel Schuepbach, Daniel Hell, Peter Boesiger, Felix Bermpohl, Ludwig Niehaus, Heinz Boeker, Georg Northoff

Research output: Contribution to journalArticle

279 Citations (Scopus)

Abstract

Background: Although recent neuroimaging and therapeutic transcranial magnetic cortex stimulation (TMS) studies suggest imbalance between left and right dorsolateral prefrontal cortex (DLPFC) in major depressive disorder (MDD) the fundamental neuropsychological characterization of left DLPFC hypoactivity and right DLPFC hyperactivity in MDD remains poorly understood. Methods: We used event-related functional magnetic resonance imaging (fMRI) to investigate neural activity in left and right DLPFC related to unattended (unexpected) and attended (expected) judgment of emotions. Participating in the study were 20 medication-free patients with MDD and 30 healthy subjects. Results: The MDD patients showed hypoactivity in the left DLPFC during both unattended and attended emotional judgment and hyperactivity in the right DLPFC during attended emotional judgment. In contrast to healthy subjects, left DLPFC activity during emotional judgment was not parametrically modulated by negative emotional valence and was inversely modulated by positive emotional valence in MDD patients. Hyperactivity in the right DLPFC correlated with depression severity. Conclusions: Results demonstrate that left DLPFC hypoactivity is associated with negative emotional judgment rather than with emotional perception or attention while right DLPFC hyperactivity is linked to attentional modulation. Left-right DLPFC imbalance is characterized in neuropsychological regard, which bridges the gap from resting metabolism and therapeutic repetitive transcranial magnetic stimulation effects to functional neuroanatomy of altered emotional-cognitive interaction in MDD.

Original languageEnglish
Pages (from-to)369-376
Number of pages8
JournalBiological Psychiatry
Volume63
Issue number4
DOIs
Publication statusPublished - Feb 15 2008

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Major Depressive Disorder
Prefrontal Cortex
Magnetic Resonance Imaging
Depression
Transcranial Magnetic Stimulation
Healthy Volunteers
Neuroanatomy
Neuroimaging
Emotions

Keywords

  • Emotional judgment
  • event-related fMRI
  • left-right DLPFC imbalance
  • MDD

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Imbalance between Left and Right Dorsolateral Prefrontal Cortex in Major Depression Is Linked to Negative Emotional Judgment : An fMRI Study in Severe Major Depressive Disorder. / Grimm, Simone; Beck, Johannes; Schuepbach, Daniel; Hell, Daniel; Boesiger, Peter; Bermpohl, Felix; Niehaus, Ludwig; Boeker, Heinz; Northoff, Georg.

In: Biological Psychiatry, Vol. 63, No. 4, 15.02.2008, p. 369-376.

Research output: Contribution to journalArticle

Grimm, Simone ; Beck, Johannes ; Schuepbach, Daniel ; Hell, Daniel ; Boesiger, Peter ; Bermpohl, Felix ; Niehaus, Ludwig ; Boeker, Heinz ; Northoff, Georg. / Imbalance between Left and Right Dorsolateral Prefrontal Cortex in Major Depression Is Linked to Negative Emotional Judgment : An fMRI Study in Severe Major Depressive Disorder. In: Biological Psychiatry. 2008 ; Vol. 63, No. 4. pp. 369-376.
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