Imaging of regional metabolic activity by 18F-FDG/PET in rats with transient cerebral ischemia

Ying Kai Fu, Chia Jung Chang, Kuan Yin Chen, Li Chung Hwang, Kuo Hung Wu, Kang Wei Chang, Meei Ling Jan, Chia Chieh Chen, Chih Hsien Chang

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Abstract

Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that 18F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with 18F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents.

Original languageEnglish
Pages (from-to)1743-1747
Number of pages5
JournalApplied Radiation and Isotopes
Volume67
Issue number10
DOIs
Publication statusPublished - Oct 1 2009
Externally publishedYes

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Keywords

  • F-FDG
  • MicroPET
  • Rat ischemia model

ASJC Scopus subject areas

  • Radiation

Cite this

Fu, Y. K., Chang, C. J., Chen, K. Y., Hwang, L. C., Wu, K. H., Chang, K. W., Jan, M. L., Chen, C. C., & Chang, C. H. (2009). Imaging of regional metabolic activity by 18F-FDG/PET in rats with transient cerebral ischemia. Applied Radiation and Isotopes, 67(10), 1743-1747. https://doi.org/10.1016/j.apradiso.2009.03.002