Imaging neurovascular function and functional recovery after stroke in the rat striatum using forepaw stimulation

Yen-Yu Shih, Shiliang Huang, You-Yin Chen, Hsin-Yi Lai, Yu-Chieh Jill Kao, Fang Du, Edward S. Hui, Timothy Q. Duong

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Negative functional magnetic resonance imaging (fMRI) response in the striatum has been observed in several studies during peripheral sensory stimulation, but its relationship between local field potential (LFP) remains to be elucidated. We performed cerebral blood volume (CBV) fMRI and LFP recordings in normal rats during graded noxious forepaw stimulation at nine stimulus pulse widths. Albeit high LFP-CBV correlation was found in the ipsilateral and contralateral sensory cortices (r = 0.89 and 0.95, respectively), the striatal CBV responses were neither positively, nor negatively correlated with LFP (r = 0.04), demonstrating that the negative striatal CBV response is not originated from net regional inhibition. To further identify whether this negative CBV response can serve as a marker for striatal functional recovery, two groups of rats (n = 5 each) underwent 20- and 45-minute middle cerebral artery occlusion (MCAO) were studied. No CBV response was found in the ipsilateral striatum in both groups immediately after stroke. Improved striatal CBV response was observed on day 28 in the 20-minute MCAO group compared with the 45-minute MCAO group (P
Original languageEnglish
Pages (from-to)1483-1492
Number of pages10
JournalJournal of Cerebral Blood Flow and Metabolism
Volume34
Issue number9
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Recovery of Function
Stroke
Corpus Striatum
Middle Cerebral Artery Infarction
Magnetic Resonance Imaging
Cerebral Blood Volume

Keywords

  • Animals
  • Blood Volume
  • Cerebral Angiography
  • Corpus Striatum
  • Disease Models, Animal
  • Magnetic Resonance Angiography
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Somatosensory Cortex
  • Stroke

Cite this

Imaging neurovascular function and functional recovery after stroke in the rat striatum using forepaw stimulation. / Shih, Yen-Yu; Huang, Shiliang; Chen, You-Yin; Lai, Hsin-Yi; Kao, Yu-Chieh Jill; Du, Fang; Hui, Edward S.; Duong, Timothy Q.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 34, No. 9, 2014, p. 1483-1492.

Research output: Contribution to journalArticle

Shih, Yen-Yu ; Huang, Shiliang ; Chen, You-Yin ; Lai, Hsin-Yi ; Kao, Yu-Chieh Jill ; Du, Fang ; Hui, Edward S. ; Duong, Timothy Q. / Imaging neurovascular function and functional recovery after stroke in the rat striatum using forepaw stimulation. In: Journal of Cerebral Blood Flow and Metabolism. 2014 ; Vol. 34, No. 9. pp. 1483-1492.
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