Imaging Biomarkers as Predictors for Breast Cancer Death

Wendy Yi Ying Wu, Laszlo Tabar, Tibor Tot, Ching Yuan Fann, Amy Ming Fang Yen, Sam Li Sheng Chen, Sherry Yueh Hsia Chiu, May Mei Sheng Ku, Chen Yang Hsu, Kerri R. Beckmann, Robert A. Smith, Stephen W. Duffy, Hsiu Hsi Chen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background. To differentiate the risk of breast cancer death in a longitudinal cohort using imaging biomarkers of tumor extent and biology, specifically, the mammographic appearance, basal phenotype, histologic tumor distribution, and conventional tumor attributes. Methods. Using a prospective cohort study design, 498 invasive breast cancer patients diagnosed between 1996 and 1998 were used as the test cohort to assess the independent effects of the imaging biomarkers and other predictors on the risk of breast cancer death. External validation was performed with a cohort of 848 patients diagnosed between 2006 and 2010. Results. Mammographic tumor appearance was an independent predictor of risk of breast cancer death (P=0.0003) when conventional tumor attributes and treatment modalities were controlled. The casting type calcifications and architectural distortion were associated with 3.13-fold and 3.19-fold risks of breast cancer death, respectively. The basal phenotype independently conferred a 2.68-fold risk compared with nonbasal phenotype. The observed deaths did not differ significantly from expected deaths in the validation cohort. The application of imaging biomarkers together with other predictors classified twelve categories of risk for breast cancer death. Conclusion. Combining imaging biomarkers such as the mammographic appearance of the tumor with the histopathologic distribution and basal phenotype, accurately predicted long-term risk of breast cancer death. The information may be relevant for determining the need for molecular testing, planning treatment, and determining the most appropriate clinical surveillance schedule for breast cancer patients.

Original languageEnglish
Article number2087983
JournalJournal of Oncology
Volume2019
DOIs
Publication statusPublished - Jan 1 2019

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Biomarkers
Breast Neoplasms
Phenotype
Neoplasms
Tumor Biomarkers
Appointments and Schedules
Cohort Studies
Prospective Studies
Therapeutics

ASJC Scopus subject areas

  • Oncology

Cite this

Wu, W. Y. Y., Tabar, L., Tot, T., Fann, C. Y., Yen, A. M. F., Chen, S. L. S., ... Chen, H. H. (2019). Imaging Biomarkers as Predictors for Breast Cancer Death. Journal of Oncology, 2019, [2087983]. https://doi.org/10.1155/2019/2087983

Imaging Biomarkers as Predictors for Breast Cancer Death. / Wu, Wendy Yi Ying; Tabar, Laszlo; Tot, Tibor; Fann, Ching Yuan; Yen, Amy Ming Fang; Chen, Sam Li Sheng; Chiu, Sherry Yueh Hsia; Ku, May Mei Sheng; Hsu, Chen Yang; Beckmann, Kerri R.; Smith, Robert A.; Duffy, Stephen W.; Chen, Hsiu Hsi.

In: Journal of Oncology, Vol. 2019, 2087983, 01.01.2019.

Research output: Contribution to journalArticle

Wu, WYY, Tabar, L, Tot, T, Fann, CY, Yen, AMF, Chen, SLS, Chiu, SYH, Ku, MMS, Hsu, CY, Beckmann, KR, Smith, RA, Duffy, SW & Chen, HH 2019, 'Imaging Biomarkers as Predictors for Breast Cancer Death', Journal of Oncology, vol. 2019, 2087983. https://doi.org/10.1155/2019/2087983
Wu, Wendy Yi Ying ; Tabar, Laszlo ; Tot, Tibor ; Fann, Ching Yuan ; Yen, Amy Ming Fang ; Chen, Sam Li Sheng ; Chiu, Sherry Yueh Hsia ; Ku, May Mei Sheng ; Hsu, Chen Yang ; Beckmann, Kerri R. ; Smith, Robert A. ; Duffy, Stephen W. ; Chen, Hsiu Hsi. / Imaging Biomarkers as Predictors for Breast Cancer Death. In: Journal of Oncology. 2019 ; Vol. 2019.
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abstract = "Background. To differentiate the risk of breast cancer death in a longitudinal cohort using imaging biomarkers of tumor extent and biology, specifically, the mammographic appearance, basal phenotype, histologic tumor distribution, and conventional tumor attributes. Methods. Using a prospective cohort study design, 498 invasive breast cancer patients diagnosed between 1996 and 1998 were used as the test cohort to assess the independent effects of the imaging biomarkers and other predictors on the risk of breast cancer death. External validation was performed with a cohort of 848 patients diagnosed between 2006 and 2010. Results. Mammographic tumor appearance was an independent predictor of risk of breast cancer death (P=0.0003) when conventional tumor attributes and treatment modalities were controlled. The casting type calcifications and architectural distortion were associated with 3.13-fold and 3.19-fold risks of breast cancer death, respectively. The basal phenotype independently conferred a 2.68-fold risk compared with nonbasal phenotype. The observed deaths did not differ significantly from expected deaths in the validation cohort. The application of imaging biomarkers together with other predictors classified twelve categories of risk for breast cancer death. Conclusion. Combining imaging biomarkers such as the mammographic appearance of the tumor with the histopathologic distribution and basal phenotype, accurately predicted long-term risk of breast cancer death. The information may be relevant for determining the need for molecular testing, planning treatment, and determining the most appropriate clinical surveillance schedule for breast cancer patients.",
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AU - Chen, Sam Li Sheng

AU - Chiu, Sherry Yueh Hsia

AU - Ku, May Mei Sheng

AU - Hsu, Chen Yang

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N2 - Background. To differentiate the risk of breast cancer death in a longitudinal cohort using imaging biomarkers of tumor extent and biology, specifically, the mammographic appearance, basal phenotype, histologic tumor distribution, and conventional tumor attributes. Methods. Using a prospective cohort study design, 498 invasive breast cancer patients diagnosed between 1996 and 1998 were used as the test cohort to assess the independent effects of the imaging biomarkers and other predictors on the risk of breast cancer death. External validation was performed with a cohort of 848 patients diagnosed between 2006 and 2010. Results. Mammographic tumor appearance was an independent predictor of risk of breast cancer death (P=0.0003) when conventional tumor attributes and treatment modalities were controlled. The casting type calcifications and architectural distortion were associated with 3.13-fold and 3.19-fold risks of breast cancer death, respectively. The basal phenotype independently conferred a 2.68-fold risk compared with nonbasal phenotype. The observed deaths did not differ significantly from expected deaths in the validation cohort. The application of imaging biomarkers together with other predictors classified twelve categories of risk for breast cancer death. Conclusion. Combining imaging biomarkers such as the mammographic appearance of the tumor with the histopathologic distribution and basal phenotype, accurately predicted long-term risk of breast cancer death. The information may be relevant for determining the need for molecular testing, planning treatment, and determining the most appropriate clinical surveillance schedule for breast cancer patients.

AB - Background. To differentiate the risk of breast cancer death in a longitudinal cohort using imaging biomarkers of tumor extent and biology, specifically, the mammographic appearance, basal phenotype, histologic tumor distribution, and conventional tumor attributes. Methods. Using a prospective cohort study design, 498 invasive breast cancer patients diagnosed between 1996 and 1998 were used as the test cohort to assess the independent effects of the imaging biomarkers and other predictors on the risk of breast cancer death. External validation was performed with a cohort of 848 patients diagnosed between 2006 and 2010. Results. Mammographic tumor appearance was an independent predictor of risk of breast cancer death (P=0.0003) when conventional tumor attributes and treatment modalities were controlled. The casting type calcifications and architectural distortion were associated with 3.13-fold and 3.19-fold risks of breast cancer death, respectively. The basal phenotype independently conferred a 2.68-fold risk compared with nonbasal phenotype. The observed deaths did not differ significantly from expected deaths in the validation cohort. The application of imaging biomarkers together with other predictors classified twelve categories of risk for breast cancer death. Conclusion. Combining imaging biomarkers such as the mammographic appearance of the tumor with the histopathologic distribution and basal phenotype, accurately predicted long-term risk of breast cancer death. The information may be relevant for determining the need for molecular testing, planning treatment, and determining the most appropriate clinical surveillance schedule for breast cancer patients.

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