12 Citations (Scopus)


Background: Kawasaki disease (KD) is known to be associated with T help (Th) 2 reaction and subsequently allergic diseases. Interleukin-31 (IL-31) has also been reported to be involved in Th2 mediated diseases such as allergic diseases. However, the role of IL-31 in KD has not been previously reported. The aim of this study is to investigate whether IL-31 is associated with KD and its clinical outcome. Material: A total of 78 KD patients who met the criteria of KD were enrolled in this study as well as 20 age-matched controls. Plasma samples were conducted to measure IL-31 before intravenous immunoglobulin (IVIG) treatment (KD1), within 3 days after IVIG treatment (KD2) and at least 3 weeks after IVIG treatment (KD3) by utilizing enzyme-linked immunosorbent assay (ELISA). Result: Our findings showed that IL-31 expression was higher in KD patients after IVIG treatment significantly (KD2>KD1: 1265.0±199.3 vs. 840.2∓152.5 pg/ml, p

Original languageEnglish
Article numbere105195
JournalPLoS One
Issue number8
Publication statusPublished - Aug 14 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Tseng, W. N., Lo, M. H., Guo, M. M. H., Hsieh, K. S., Chang, W. C., & Kuo, H. C. (2014). IL-31 associated with coronary artery lesion formation in Kawasaki disease. PLoS One, 9(8), [e105195]. https://doi.org/10.1371/journal.pone.0105195