IL-20: Biological functions and clinical implications

Chi Chen Wei, Yu Hsiang Hsu, Hsing Hui Li, Yo Ching Wang, Mei Yi Hsieh, Wei Yu Chen, Chung-Hsi Hsing, Ming Shi Chang

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

IL-20 belongs to the IL-10 family and plays a role in skin inflammation and the development of hematopoietic cells. Little is known about its other biological functions and clinical implications, however. Updated information about IL-20, such as its identification, expression, receptors, signaling, biological activities, and potential clinical implications, is illustrated in this review based on our research and on data available in the literature. Our studies of IL-20 show that it is a pleiotropic cytokine with potent inflammatory, angiogenic, and chemoattractive characteristics. Inflammation and angiogenesis are essential for the pathogenesis of rheumatoid arthritis and atherosclerosis. Based on in vitro data and clinical samples, we demonstrated that IL-20 is involved in the diseases of rheumatoid arthritis and atherosclerosis. In addition, we found in our studies that IL-20 signaled through different molecules in several cells. The present review presents the clinical implications of IL-20 in rheumatoid arthritis and atherosclerosis. It may provide new therapeutic options in the future.

Original languageEnglish
Pages (from-to)601-612
Number of pages12
JournalJournal of Biomedical Science
Volume13
Issue number5
DOIs
Publication statusPublished - Sep 2006
Externally publishedYes

Fingerprint

Rheumatoid Arthritis
Atherosclerosis
Inflammation
Bioactivity
Interleukin-10
interleukin 20
Skin
Cytokines
Molecules
Research
Therapeutics
In Vitro Techniques

Keywords

  • Angiogenesis
  • Atherosclerosis
  • IL-20
  • Inflammation
  • Psoriasis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wei, C. C., Hsu, Y. H., Li, H. H., Wang, Y. C., Hsieh, M. Y., Chen, W. Y., ... Chang, M. S. (2006). IL-20: Biological functions and clinical implications. Journal of Biomedical Science, 13(5), 601-612. https://doi.org/10.1007/s11373-006-9087-5

IL-20 : Biological functions and clinical implications. / Wei, Chi Chen; Hsu, Yu Hsiang; Li, Hsing Hui; Wang, Yo Ching; Hsieh, Mei Yi; Chen, Wei Yu; Hsing, Chung-Hsi; Chang, Ming Shi.

In: Journal of Biomedical Science, Vol. 13, No. 5, 09.2006, p. 601-612.

Research output: Contribution to journalArticle

Wei, CC, Hsu, YH, Li, HH, Wang, YC, Hsieh, MY, Chen, WY, Hsing, C-H & Chang, MS 2006, 'IL-20: Biological functions and clinical implications', Journal of Biomedical Science, vol. 13, no. 5, pp. 601-612. https://doi.org/10.1007/s11373-006-9087-5
Wei CC, Hsu YH, Li HH, Wang YC, Hsieh MY, Chen WY et al. IL-20: Biological functions and clinical implications. Journal of Biomedical Science. 2006 Sep;13(5):601-612. https://doi.org/10.1007/s11373-006-9087-5
Wei, Chi Chen ; Hsu, Yu Hsiang ; Li, Hsing Hui ; Wang, Yo Ching ; Hsieh, Mei Yi ; Chen, Wei Yu ; Hsing, Chung-Hsi ; Chang, Ming Shi. / IL-20 : Biological functions and clinical implications. In: Journal of Biomedical Science. 2006 ; Vol. 13, No. 5. pp. 601-612.
@article{b5c1466e057749618ed75edb85a45744,
title = "IL-20: Biological functions and clinical implications",
abstract = "IL-20 belongs to the IL-10 family and plays a role in skin inflammation and the development of hematopoietic cells. Little is known about its other biological functions and clinical implications, however. Updated information about IL-20, such as its identification, expression, receptors, signaling, biological activities, and potential clinical implications, is illustrated in this review based on our research and on data available in the literature. Our studies of IL-20 show that it is a pleiotropic cytokine with potent inflammatory, angiogenic, and chemoattractive characteristics. Inflammation and angiogenesis are essential for the pathogenesis of rheumatoid arthritis and atherosclerosis. Based on in vitro data and clinical samples, we demonstrated that IL-20 is involved in the diseases of rheumatoid arthritis and atherosclerosis. In addition, we found in our studies that IL-20 signaled through different molecules in several cells. The present review presents the clinical implications of IL-20 in rheumatoid arthritis and atherosclerosis. It may provide new therapeutic options in the future.",
keywords = "Angiogenesis, Atherosclerosis, IL-20, Inflammation, Psoriasis, Rheumatoid arthritis",
author = "Wei, {Chi Chen} and Hsu, {Yu Hsiang} and Li, {Hsing Hui} and Wang, {Yo Ching} and Hsieh, {Mei Yi} and Chen, {Wei Yu} and Chung-Hsi Hsing and Chang, {Ming Shi}",
year = "2006",
month = "9",
doi = "10.1007/s11373-006-9087-5",
language = "English",
volume = "13",
pages = "601--612",
journal = "Journal of Biomedical Science",
issn = "1021-7770",
publisher = "BioMed Central",
number = "5",

}

TY - JOUR

T1 - IL-20

T2 - Biological functions and clinical implications

AU - Wei, Chi Chen

AU - Hsu, Yu Hsiang

AU - Li, Hsing Hui

AU - Wang, Yo Ching

AU - Hsieh, Mei Yi

AU - Chen, Wei Yu

AU - Hsing, Chung-Hsi

AU - Chang, Ming Shi

PY - 2006/9

Y1 - 2006/9

N2 - IL-20 belongs to the IL-10 family and plays a role in skin inflammation and the development of hematopoietic cells. Little is known about its other biological functions and clinical implications, however. Updated information about IL-20, such as its identification, expression, receptors, signaling, biological activities, and potential clinical implications, is illustrated in this review based on our research and on data available in the literature. Our studies of IL-20 show that it is a pleiotropic cytokine with potent inflammatory, angiogenic, and chemoattractive characteristics. Inflammation and angiogenesis are essential for the pathogenesis of rheumatoid arthritis and atherosclerosis. Based on in vitro data and clinical samples, we demonstrated that IL-20 is involved in the diseases of rheumatoid arthritis and atherosclerosis. In addition, we found in our studies that IL-20 signaled through different molecules in several cells. The present review presents the clinical implications of IL-20 in rheumatoid arthritis and atherosclerosis. It may provide new therapeutic options in the future.

AB - IL-20 belongs to the IL-10 family and plays a role in skin inflammation and the development of hematopoietic cells. Little is known about its other biological functions and clinical implications, however. Updated information about IL-20, such as its identification, expression, receptors, signaling, biological activities, and potential clinical implications, is illustrated in this review based on our research and on data available in the literature. Our studies of IL-20 show that it is a pleiotropic cytokine with potent inflammatory, angiogenic, and chemoattractive characteristics. Inflammation and angiogenesis are essential for the pathogenesis of rheumatoid arthritis and atherosclerosis. Based on in vitro data and clinical samples, we demonstrated that IL-20 is involved in the diseases of rheumatoid arthritis and atherosclerosis. In addition, we found in our studies that IL-20 signaled through different molecules in several cells. The present review presents the clinical implications of IL-20 in rheumatoid arthritis and atherosclerosis. It may provide new therapeutic options in the future.

KW - Angiogenesis

KW - Atherosclerosis

KW - IL-20

KW - Inflammation

KW - Psoriasis

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=33749259116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749259116&partnerID=8YFLogxK

U2 - 10.1007/s11373-006-9087-5

DO - 10.1007/s11373-006-9087-5

M3 - Article

C2 - 16703417

AN - SCOPUS:33749259116

VL - 13

SP - 601

EP - 612

JO - Journal of Biomedical Science

JF - Journal of Biomedical Science

SN - 1021-7770

IS - 5

ER -