IL-17 cytokine family

Mio Kawaguchi, Mitsuru Adachi, Naruhito Oda, Fumio Kokubu, Shau Ku Huang

Research output: Contribution to journalReview article

252 Citations (Scopus)

Abstract

A new family of cytokines, IL-17, has recently been defined that reveals a distinct ligand-receptor signaling system. Functional studies have provided evidence for its importance in the regulation of immune responses. Notably, 3 members, IL-17A, IL-17E (IL-25), and IL-17F, have been best characterized both in vitro and in vivo, and have been shown to be proinflammatory in nature. This proinflammatory activity is exemplified by their involvement in pulmonary inflammatory responses, in which both IL-17A and IL-17F are involved in the recruitment of neutrophils, and IL-17E is able to induce T H2 cytokine production and eosinophilia. Although the elucidation of a detailed mechanism of action continues to be an active area of research, the potent inflammatory activity and its association with various human disease states suggest this new cytokine family as an important contributor to the pathophysiology of human disease conditions, in particular the pulmonary diseases.

Original languageEnglish
Pages (from-to)1265-1273
Number of pages9
JournalJournal of Allergy and Clinical Immunology
Volume114
Issue number6
DOIs
Publication statusPublished - Dec 1 2004
Externally publishedYes

Keywords

  • IL-17 family
  • IL-17A
  • IL-17E (IL-25)
  • IL-17F

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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