IGF1 gene is associated with triglyceride levels in subjects with family history of hypertension from the SAPPHIRe and TWB projects

Wen Chang Wang, Yen Feng Chiu, Ren Hua Chung, Chii Min Hwu, I. Te Lee, Chien Hsing Lee, Yi Cheng Chang, Kuan Yi Hung, Thomas Quertermous, Yii Der I. Chen, Chao A. Hsiung

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Abstract

Chromosome 12q23-q24 has been linked to triglyceride (TG) levels by previous linkage studies, and it contains the Insulin-like growth factor 1 (IGF1) gene. We investigated the association between IGF1 and TG levels using two independent samples collected in Taiwan. First, based on 954 siblings in 397 families from the Stanford Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe), we found that rs978458 was associated with TG levels (β =-0.049, p = 0.0043) under a recessive genetic model. Specifically, subjects carrying the homozygous genotype of the minor allele had lower TG levels, compared with other subjects. Then, a series of stratification analyses in a large sample of 13,193 unrelated subjects from the Taiwan biobank (TWB) project showed that this association appeared in subjects with a family history (FH) of hypertension (β =-0.045, p = 0.0000034), but not in subjects without such an FH. A re-examination of the SAPPHIRe sample confirmed that this association appeared in subjects with an FH of hypertension (β =-0.068, p = 0.0025), but not in subjects without an FH. The successful replication in two independent samples indicated that IGF1 is associated with TG levels in subjects with an FH of hypertension in Taiwan.

Original languageEnglish
Pages (from-to)1035-1042
Number of pages8
JournalInternational Journal of Medical Sciences
Volume15
Issue number10
DOIs
Publication statusPublished - Jun 14 2018

Keywords

  • Family history of hypertension
  • IGF1
  • Insulin-like growth factor 1
  • Single-nucleotide polymorphism
  • Triglyceride

ASJC Scopus subject areas

  • Medicine(all)

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    Wang, W. C., Chiu, Y. F., Chung, R. H., Hwu, C. M., Lee, I. T., Lee, C. H., Chang, Y. C., Hung, K. Y., Quertermous, T., Chen, Y. D. I., & Hsiung, C. A. (2018). IGF1 gene is associated with triglyceride levels in subjects with family history of hypertension from the SAPPHIRe and TWB projects. International Journal of Medical Sciences, 15(10), 1035-1042. https://doi.org/10.7150/ijms.25742