Idiopathic hypereosinophilic syndrome with eosinophilic myositis, peripheral neuropathy and central nervous system involvement

Jiann D. Lee, Sien Tsong Chen, Chi J. Chen, Chiung M. Chen, Long S. Ro

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Idiopathic hypereosinophilic syndrome (HES) is a rare disorder marked by a sustained overproduction of eosinophils and a predilection for damage to multiple organ systems. Its neurologic involvement ranges from the central to the peripheral nervous system, and can be associated with eosinophilic myositis. We report a 68-year-old woman who had eosinophilia, eosinophilic dermatitis and eosinophilic pneumonia. She also suffered from numbness and weakness of the lower limbs. Because of long-lasting (>6 mo) eosinophilia (>1.5 x 109/L) in the peripheral blood and the fact that no other underlying causes of eosinophilia and neurologic involvement could be identified, a diagnosis of idiopathic hypereosinophilic syndrome was made. The muscle biopsy showed infiltration of inflammatory cells, including a few eosinophils (Liu's stain). Magnetic resonance images, motor evoked potentials, somatosensory evoked potentials and nerve conduction velocities also showed abnormalities in the central and peripheral nervous systems. The pathogenesis and treatments of HES are discussed in this report.

Original languageEnglish
Pages (from-to)933-936
Number of pages4
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume95
Issue number12
Publication statusPublished - Dec 1996
Externally publishedYes

Fingerprint

Hypereosinophilic Syndrome
Peripheral Nervous System
Eosinophilia
Peripheral Nervous System Diseases
Central Nervous System
Eosinophils
Nervous System
Pulmonary Eosinophilia
Motor Evoked Potentials
Somatosensory Evoked Potentials
Hypesthesia
Neural Conduction
Dermatitis
Lower Extremity
Coloring Agents
Magnetic Resonance Spectroscopy
Biopsy
Muscles
Limb-girdle muscular dystrophy type 2A
Therapeutics

Keywords

  • central nervous system
  • eosinophilic myositis
  • idiopathic hypereosinophilic syndrome
  • peripheral neuropathy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Idiopathic hypereosinophilic syndrome with eosinophilic myositis, peripheral neuropathy and central nervous system involvement. / Lee, Jiann D.; Chen, Sien Tsong; Chen, Chi J.; Chen, Chiung M.; Ro, Long S.

In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 95, No. 12, 12.1996, p. 933-936.

Research output: Contribution to journalArticle

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